1. Alcohol Use and Cardiovascular Disease Risk in Patients With Nonalcoholic Fatty Liver Disease
- Author
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VanWagner, Lisa B, Ning, Hongyan, Allen, Norrina B, Ajmera, Veeral, Lewis, Cora E, Carr, John Jeffrey, Lloyd-Jones, Donald M, Terrault, Norah A, and Siddique, Juned
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Alcoholism ,Alcohol Use and Health ,Liver Disease ,Chronic Liver Disease and Cirrhosis ,Cardiovascular ,Prevention ,Nutrition ,Heart Disease ,Heart Disease - Coronary Heart Disease ,Substance Misuse ,Digestive Diseases ,Clinical Research ,2.3 Psychological ,social and economic factors ,Aetiology ,Stroke ,Oral and gastrointestinal ,Good Health and Well Being ,Adolescent ,Adult ,Age Factors ,Alcohol Drinking ,Binge Drinking ,Chi-Square Distribution ,Coronary Artery Disease ,Cross-Sectional Studies ,Echocardiography ,Doppler ,Female ,Humans ,Linear Models ,Logistic Models ,Longitudinal Studies ,Male ,Middle Aged ,Multidetector Computed Tomography ,Multivariate Analysis ,Non-alcoholic Fatty Liver Disease ,Odds Ratio ,Prognosis ,Protective Factors ,Risk Assessment ,Risk Factors ,Time Factors ,Underage Drinking ,United States ,Young Adult ,CARDIA Study ,NASH ,NAFLD ,Neurosciences ,Paediatrics and Reproductive Medicine ,Gastroenterology & Hepatology ,Clinical sciences ,Nutrition and dietetics - Abstract
Background & aimsCardiovascular disease (CVD) is the leading cause of death among patients with nonalcoholic fatty liver disease (NAFLD). Moderate drinking (vs abstinence) is associated with lower risk of CVD in the general population. We assessed whether alcohol use is associated with CVD risk in patients with NAFLD.MethodsWe analyzed data from participants in the Coronary Artery Risk Development in Young Adults longitudinal cohort study of 5115 black and white young adults, 18-30 years old, recruited from 4 cities in the United States from 1985 through 1986. Participants self-reported alcohol use at study entry and then again after 15, 20, and 25 years. At year 25 (2010-2011), participants underwent computed tomography examination of the thorax and abdomen and tissue Doppler echocardiography with myocardial strain measured by speckle tracking. Coronary artery calcification was defined as an Agatston score above 0. NAFLD was defined as liver attenuation
- Published
- 2017