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58 results on '"Ioan Sporea"'

10. Mo1926 PROBIOTICS FOR THE PREVENTION OF CLOSTRIDIUM DIFFICILE INFECTION AMONG PATIENTS UNDERGOING ANTIBIOTIC THERAPY

Author

Tudor Moga, Mirabela M. Topan, Ioan Sporea, Roxana Sirli, Andrada-Patricia Belintan, Alina Popescu, Camelia Gianina Foncea, Radu Cotrau, Mirela Danila, and Raluca Lupusoru

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Antibiotic therapy, Gastroenterology, medicine, Clostridium difficile, business
Published
2020
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11. Tu1625 NON-INVASIVE TECHNIQUES FOR SCREENING OF SIGNIFICANT LIVER FIBROSIS AND STEATOSIS IN PATIENTS WITH ALCOHOL USE DISORDER

Author

Mirela Danila, Camelia Gianina Foncea, Ioan Sporea, Tudor Moga, Alina Popescu, Roxana Sirli, and Raluca Lupusoru

Subjects
medicine.medical_specialty, Hepatology, business.industry, Liver fibrosis, Non invasive, Gastroenterology, Alcohol use disorder, medicine.disease, Internal medicine, medicine, In patient, Steatosis, business
Published
2020
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13. Mo1464 PREDICTORS OF STEATOSIS SEVERITY IN PATIENTS WITH METABOLIC SYNDROME

Author

Silviu Nistorescu, Ruxandra Mare, Roxana Sirli, Patricia Lupulescu, Alina Popescu, Andrei Vitel, Ioan Sporea, Gheorghe Nicusor Pop, and Mirela Cleopatra Tomescu

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, In patient, Metabolic syndrome, Steatosis, medicine.disease, business
Published
2020
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14. Predictors of Liver Stiffness Regression after SVR in Cirrhotic Patients Treated with 3D Regimen

Author

Ciprian Brisc, Corina Pietrareanu, Liliana Gheorghe, Livia Hara, Mircea Diculescu, Roxana Vadan, Manuela Curescu, Luana Alexandrescu, Speranta Iacob, Anca Trifan, Razvan Iacob, Cristian Gheorghe, Carol Stanciu, Andrada Seicean, Larisa Săndulescu, Ion Rogoveanu, Iuliana Pirvulescu, Roxana Sirli, Victoria Aramă, Florin Alexandru Caruntu, Iulia Simionov, Ioan Sporea, Cristina Cijevschi Prelipcean, Adrian Goldis, and Catalina Mihai

Subjects
medicine.medical_specialty, Regimen, Hepatology, Liver stiffness, business.industry, Internal medicine, Gastroenterology, medicine, business, Regression
Published
2017
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15. Tu1556 - The Value of Ultrasound Based Elastographic Methods for Ruling Out the Presence of Esophageal Varices in Liver Cirrhotic Patients

Author

Raluca Lupusoru, Ioan Sporea, Tudor Moga, Camelia Gianina Foncea, Ruxandra Mare, Roxana Sirli, Felix Bende, Corina Pienar, Alina Popescu, Diana Gerhadt, AM Stepan, Mirela Danila, and B Miutescu

Subjects
medicine.medical_specialty, Esophageal varices, Hepatology, business.industry, Ultrasound, Gastroenterology, medicine, Radiology, business, medicine.disease, Value (mathematics)
Published
2018
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18. Efficacy and Safety of Paritaprevir/Ritonavir, Ombitasvir and Dasabuvir Plus/Minus Ribavirin for Treatment of HCV Genotype 1B Compensated Cirrhosis in Patients Aged 70 Years or Older

Author

Liana Gheorghe, Andra Iulia Suceveanu, Egidia Miftode, Camelia Cojocariu, Manuela Curescu, Irina Ciortescu, Catalina Mihai, Carol Stanciu, Ana-Maria Singeap, Irina Girleanu, Ioan Sporea, Cristina Cijevschi Prelipcean, Stefan Chiriac, Ion Rogoveanu, Simona Bataga, Alina Popescu, Speranta Iacob, Victoria Aramă, Ciprian Brisc, Adrian Goldis, Tudor Cuciureanu, Oana Stoica, Gabriela Stefanescu, Catalin Sfarti, and Anca Trifan

Subjects
medicine.medical_specialty, Cirrhosis, Dasabuvir, Hepatology, business.industry, Ribavirin, Gastroenterology, medicine.disease, Virology, Ombitasvir, chemistry.chemical_compound, Genotype 1b, chemistry, Paritaprevir, Internal medicine, medicine, Ritonavir, In patient, business, medicine.drug
Published
2017
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19. Dynamic of Liver Stiffness Values by Means of Transient Elastography in Patients with HCV Liver Cirrhosis Undergoing Interferon Free Treatment

Author

Raluca Lupusoru, Liana Gheorghe, Ioan Sporea, Ruxandra Mare, Speranta Iacob, Mirela Danila, Alina Popescu, Larisa Săndulescu, and Roxana Sirli

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Interferon free, Gastroenterology, 02 engineering and technology, 021001 nanoscience & nanotechnology, medicine.disease, Liver stiffness, Internal medicine, 0202 electrical engineering, electronic engineering, information engineering, medicine, 020201 artificial intelligence & image processing, In patient, 0210 nano-technology, Transient elastography, business
Published
2017
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20. Proposed Cut-Offs in HCV Chronic Liver Disease Using ElastPQ

Author

Raluca Lupusoru, Ruxandra Mare, Ioan Sporea, Roxana Sirli, Felix Bende, AM Stepan, Mirela Danila, and Alina Popescu

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, business, Chronic liver disease, medicine.disease
Published
2017
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21. Prospective Analysis of Discordant Results Between Fibromax® and Fibroscan® in Patients with HCV Compensated Liver Cirrhosis before 3D Antiviral Therapy Initiation

Author

Anca Trifan, Roxana Sirli, Florin Alexandru Caruntu, Iulia Simionov, Catalina Mihai, Razvan Iacob, Iuliana Pirvulescu, Livia Hara, Manuela Curescu, Cristian Gheorghe, Speranta Iacob, Corina Pietrareanu, Larisa Săndulescu, Liliana Gheorghe, Ioan Sporea, Cristina Cijevschi Prelipcean, Adrian Goldis, Carol Stanciu, Roxana Vadan, Ion Rogoveanu, Mircea Diculescu, Luana Alexandrescu, Ciprian Brisc, Victoria Aramă, and Andrada Seicean

Subjects
medicine.medical_specialty, Prospective analysis, Cirrhosis, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Antiviral therapy, In patient, medicine.disease, business
Published
2017
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29. Sa1003 Diagnosis of Benign and Malignant Portal Vein Thrombosis in Cirrhotic Patients With Hepatocellular Carcinoma Using Contrast-Enhanced Ultrasound (CEUS)

Author

Simona Bota, Mirela Danila, Roxana Sirli, Ioan Sporea, M. Sendroiu, and Alina Popescu

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Ultrasound, Gastroenterology, medicine.disease, Thrombosis, Portal vein thrombosis, Hepatocellular carcinoma, medicine, Radiology, Thrombus, business, Contraindication, Contrast-enhanced ultrasound
Abstract

Staging hepatocellular carcinoma (HCC) is an esential step in the decision regarding treatment options. Malignant portal vein thrombosis is a contraindication for all curative treatment, thus establishing the nature (benign or malignant) of PVT is mandatory for staging the disease. The AIM of this paper was to assess the role of contrast enhanced ultrasound (CEUS) for the staging of HCC in patients with liver cirrhosis. METHODS: We evaluated 86 consecutive patients with liver cirrhosis and known HCC, who were discovered with PVT located in different parts of the portal system. Before CEUS we performed a standard ultrasound and a Doppler examination. We used 2.4 ml of second generation contrast agent (SonoVue) for every examination. During the CEUS examination we followed the arterial, portal and late phases as defined in the EFSUMB Guidelines (1) and also the enhancement pattern as described by Rossi et al. (Type 1: thrombus enhancement is absent in all three phasesbenign thrombus; and for malign thrombus-Type 2: diffuse thrombus enhancement that is visible only during the early arterial phase; Type 3: linear or punctate enhancement; Type 4: multilinear or multipunctate enhancement)(2). RESULTS: PVT was located in the proximity of HCC in 63 of the 86 cases (73.2 %). 11 cases (12.7%) were Type 1 Rossi (benign thrombus), 44 cases (51.1%) were Type 2, 14 cases (16.2%) were Type 3 and 17 cases (19.7%) were Type 4 Rossi. Using CEUS we could characterise and obtain a conclusive diagnosis in 85 of the 86 patients (98.8%). CONCLUSIONS CEUS is a method with a good sensibility for the characterisation of PVT in patients with HCC, that allows the staging of the disease for a good therapeutic decision. BIBLIOGRAPHY: 1. M. Claudon, C. F. Dietrich, B. I. Choi, D. O. Cosgrove, M. Kudo, C. P. Nolsoe, F. Piscaglia, S. R. Wilson, R. G. Barr, M. C. Chammas, N. G. Chaubal, M.-H. Chen, D. A. Clevert, J. M. Correas, H. Ding, F. Forsberg, J. B. Fowlkes, R. N. Gibson, B. B. Goldberg, N. Lassau, E. L. S. Leen, R. F. Mattrey, F. Moriyasu, L. Solbiati, H.-P. Weskott, H.-X. Xu. Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver-Update 2012. Published online: 2012 Ultraschall in Med. 2. Rossi S. et al. Contrast-Enhanced Versus Conventional and Color Doppler Sonography for the Detection of Thrombosis of the Portal and Hepatic Venous Systems. AJR 2006; 186:763-773.

Published
2014
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30. Su1294 Epidemiological Characteristics of Chronic Hepatitis DELTA Virus Infection (CHD) in Romania

Author

Florin Alexandru Caruntu, Ioan Sporea, Andra Iulia Suceveanu, Ion Rogoveanu, Letitia P. Tugui, Anca Trifan, Irma Eva Csiki, Liana Gheorghe, Ciprian Brisc, Andrea Alexandrescu, Manuela Curescu, Adriana Motoc, Mircea Grigorescu, and Speranta Iacob

Subjects
Delta, medicine.medical_specialty, Hepatology, Chronic hepatitis, business.industry, Epidemiology, Immunology, Gastroenterology, medicine, business, Virology, Virus
Published
2013
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31. Su1801 Which Factors Influence the Reability of Liver Stiffness Measurements by Means of Transient Elastography? - Monocentric Experience

Author

Ioan Sporea, Roxana Sirli, Romulus Timar, A. Jurchis, Simona Bota, Nadia I. Cornu, Mirela Danila, Isabel Dan, Alina Popescu, Melania Ardelean, and Alexandra Deleanu

Subjects
medicine.medical_specialty, Hepatology, Liver stiffness, business.industry, Gastroenterology, Medicine, Radiology, Transient elastography, business, Biomedical engineering
Published
2013
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32. Sa1039 The Importance of Interleukin 28b Polymorphism for Prediction of Sustained Virologic Response in Chronic Hepatitis C Patients Treated With Triple Therapy Including Boceprevir or Telaprevir - A Meta-Analysis

Author

Ioan Sporea, Adriana Maria Neghină, Roxana Sirli, Alina Popescu, Simona Bota, and Mihnea Strain

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Virology, Telaprevir, chemistry.chemical_compound, Interleukin 28B, chemistry, Chronic hepatitis, Meta-analysis, Internal medicine, Boceprevir, Virologic response, medicine, business, medicine.drug
Published
2013
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33. Su1803 Which Factors Influence the Accuracy of Liver Stiffness Measurements by Transient Elastography (TE) and by Acoustic Radiation Force Impulse (ARFI) Elastography for Liver Fibrosis Evaluation? - The Analysis of a Large International Cohort of Patients

Author

Radu Badea, Christoph Sarrazin, P. Salzl, Ioan Sporea, Roxana Sirli, Monica Lupsor, Mireen Friedrich-Rust, Sara Marinelli, Simona Bota, Mirela Danila, Fabio Piscaglia, Hirotoshi Ebinuma, Hidetsugu Saito, Markus Peck-Radosavljevic, and Alina Popescu

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Liver fibrosis, Gastroenterology, Impulse (physics), Arfi elastography, Liver stiffness, Cohort, medicine, Elastography, Radiology, Acoustic radiation force, business, Transient elastography
Abstract

Which Factors Influence the Accuracy of Liver Stiffness Measurements by Transient Elastography (TE) and by Acoustic Radiation Force Impulse (ARFI) Elastography for Liver Fibrosis Evaluation? The Analysis of a Large International Cohort of Patients Simona Bota, Ioan Sporea, Markus Peck-Radosavljevic, Roxana Sirli, Hidetsugu Saito, Hirotoshi Ebinuma, Monica Platon Lupsor, Radu I. Badea, Mireen Friedrich-Rust, Christoph Sarrazin, Fabio Piscaglia, Sara Marinelli, Petra Salzl, Alina Popescu, Mirela Danila

Published
2013
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34. Tu1053 The Value of Contrast Enhanced Ultrasound (CEUS) for Focal Liver Lesions Characterization - A Multicenter Romanian Study

Author

Simona Bota, Alina Martie, Costin Teodor Streba, Ciprian Brisc, Catalina Mihai, Larisa Săndulescu, Dorina Pestroiu Calescu, Adrian Anghel, Lucian Ciobaca, Attila Tamas, Alina Popescu, Liana Gheorghe, Roxana Sirli, Mihai Socaciu, Mariana Jinga, Radu Badea, Iulia Simionov, Adrian Saftoiu, Simona Ioanitescu, Mihaela Iordache, Dana Nedelcu, Zeno Sparchez, Mirela Danila, Ioan Sporea, and Cristina Cijevschi Prelipcean

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Medicine, Radiology, business, Value (mathematics), Contrast-enhanced ultrasound
Published
2013
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35. Su1802 The Usefulness of Liver Stiffness Assessment by Means of Supersonic Shear Imaging (SSI) for Liver Fibrosis Evaluation Considering Transient Elastography As Reference Method

Author

Alina Popescu, A. Jurchis, Oana Gradinaru, Ioan Sporea, Roxana Sirli, and Simona Bota

Subjects
medicine.medical_specialty, Hepatology, Shear (geology), business.industry, Liver stiffness, Liver fibrosis, Gastroenterology, Medicine, Supersonic speed, Radiology, business, Transient elastography
Published
2013
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36. Tu1022 Is the Correlation of Liver Stiffness Assessed by Acoustic Radiation Force Impulse Elastography (ARFI) Influenced by the Aminotransferases Level? - an International Multicenter Study

Author

Christoph Sarrazin, Mireen Friedrich-Rust, Arnulf Ferlitsch, Hironori Tanaka, Simona Bota, Ana Petrisor, Hidetsugu Saito, Naofumi Ono, Mirko D'Onofrio, Alina Popescu, Markus Peck-Radosavljevic, Hiroko Iijima, Hirokazu Takahashi, Carmen Fierbinteanu Braticevici, Roxana Sirli, A. Gallotti, Alberto Borghi, Hirotoshi Ebinuma, Monica Lupsor, Radu Badea, Ioan Sporea, Mirela Danila, and Fabio Piscaglia

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Impulse (physics), Correlation, Multicenter study, Liver stiffness, medicine, Elastography, Radiology, business, Acoustic radiation force, Nuclear medicine
Published
2012
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37. 539 Can We use in Clinical Practice Acoustic Radiation Force Impulse Elastography (ARFI) to Predict the Presence of Significant Esophageal Varices in Cirrhotic Patients?

Author

Ioan Sporea, Simona Bota, Mirela Danila, Roxana Sirli, Alina Popescu, and Mircea Focsa

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Impulse (physics), medicine.disease, Clinical Practice, Esophageal varices, medicine, Elastography, Radiology, business, Acoustic radiation force
Published
2012
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38. Tu1023 Is Acoustic Radiation Force Impulse Elastography (ARFI) a Useful Method for Noninvasive Fibrosis Evaluation in Patients With Chronic Hepatitis C? - an International Multicenter Study

Author

Fabio Piscaglia, Hirotoshi Ebinuma, Carmen Fierbinteanu Braticevici, Mirko D'Onofrio, Hironori Tanaka, Christoph Sarrazin, Markus Peck-Radosavljevic, Ioan Sporea, Mireen Friedrich-Rust, Roxana Sirli, A. Gallotti, Arnulf Ferlitsch, Ana Petrisor, Mirela Danila, Simona Bota, Monica Lupsor, Radu Badea, Alberto Borghi, Naofumi Ono, Alina Popescu, Hidetsugu Saito, Hiroko Iijima, and Hirokazu Takahashi

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Impulse (physics), medicine.disease, Multicenter study, Chronic hepatitis, Fibrosis, medicine, In patient, Elastography, Radiology, Acoustic radiation force, business
Abstract

Is Acoustic Radiation Force Impulse Elastography (ARFI) a Useful Method for Noninvasive Fibrosis Evaluation in Patients With Chronic Hepatitis C? an International Multicenter Study Ioan Sporea, Simona Bota, Roxana Sirli, Hironori Tanaka, Hiroko Iijima, Radu Badea, Monica Lupsor, Carmen Fierbinteanu Braticevici, Ana Petrisor, Hidetsugu Saito, Hirotoshi Ebinuma, Mireen Friedrich-Rust, Christoph Sarrazin, Hirokazu Takahashi, Naofumi Ono, Fabio Piscaglia, Alberto Borghi, Mirko D'Onofrio, Anna Gallotti, Markus PeckRadosavljevic, Arnulf Ferlitsch, Alina Popescu, Mirela Danila

Published
2012
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39. Mo1929 Intra and Interoperator Reproducibility of Acoustic Radiation Force Impulse Elastography (ARFI)

Author

Ioan Sporea, D. Suseanu, Alina Popescu, M. Sendroiu, Simona Bota, A. Jurchis, Alina Martie, Mirela Danila, and Roxana Sirli

Subjects
Physics, medicine.medical_specialty, Reproducibility, Hepatology, medicine.diagnostic_test, Gastroenterology, medicine, Radiology, Elastography, Impulse (physics), Acoustic radiation force, Biomedical engineering
Published
2012
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40. Tu1024 Which Elastographic Method (Transient Elastography or ARFI) is More Useful for Liver Fibrosis Evaluation in Patients With Chronic Hepatitis C? - an International Multicenter Study

Author

Ioan Sporea, Hirotoshi Ebinuma, Arnulf Ferlitsch, Fabio Piscaglia, Christoph Sarrazin, Roxana Sirli, Simona Bota, Radu Badea, Hidetsugu Saito, Monica Lupsor, Mirela Danila, Markus Peck-Radosavljevic, Mireen Friedrich-Rust, Alina Popescu, and Alberto Borghi

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Liver fibrosis, Gastroenterology, medicine.disease, Chronic hepatitis, Multicenter study, Fibrosis, medicine, In patient, Elastography, Radiology, Transient elastography, business
Abstract

Is Acoustic Radiation Force Impulse Elastography (ARFI) a Useful Method for Noninvasive Fibrosis Evaluation in Patients With Chronic Hepatitis C? an International Multicenter Study Ioan Sporea, Simona Bota, Roxana Sirli, Hironori Tanaka, Hiroko Iijima, Radu Badea, Monica Lupsor, Carmen Fierbinteanu Braticevici, Ana Petrisor, Hidetsugu Saito, Hirotoshi Ebinuma, Mireen Friedrich-Rust, Christoph Sarrazin, Hirokazu Takahashi, Naofumi Ono, Fabio Piscaglia, Alberto Borghi, Mirko D'Onofrio, Anna Gallotti, Markus PeckRadosavljevic, Arnulf Ferlitsch, Alina Popescu, Mirela Danila

Published
2012
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43. Is It Better to Use Together Transient Elastography (TE) and Acoustic Radiation Force Impulse Elastography (ARFI) for Fibrosis Evaluation in Patients With Chronic HCV Hepatitis?

Author

Ioan Sporea, Simona Bota, Roxana Sirli, Alina Popescu, Radu Badea, Mircea Focsa, Mirela Danila, and Monica Lupsor

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Impulse (physics), medicine.disease, Fibrosis, Hcv hepatitis, medicine, In patient, Elastography, Radiology, Acoustic radiation force, Transient elastography, business
Published
2011
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45. Acoustic Radiation Force Impulse Elastography (ARFI) for Predicting the Severity of Fibrosis in Patients With Chronic HCV Hepatitis – A Bicentric Romanian Study

Author

Mirela Danila, Ioan Sporea, Roxana Sirli, Simona Bota, Carmen Fierbinteanu Braticevici, Ana Petrisor, and Alina Popescu

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Impulse (physics), medicine.disease, Fibrosis, Hcv hepatitis, medicine, In patient, Elastography, Radiology, Acoustic radiation force, business
Published
2011
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46. S1910 Risk Factors for Rebleeding and Mortality in Variceal Hemorrhage

Author

Ioan Sporea, Iulia Ratiu, Daniela E. Lazar, and Adrian Goldis

Subjects
medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Gastroenterology, Hemodynamics, Patient data, Variceal hemorrhage, medicine.disease, Internal medicine, Vasoactive, medicine, Etiology, Portal hypertension, Transient elastography, business
Abstract

Introduction: Recently published studies support the use of transient elastography (TE) for evaluating patients with portal hypertension since liver stiffness (LS) is significantly correlated with the hepatovenous pressure gradient (HVPG). However, negative (NPV) and positive predictive values (PPV) for diagnosis of clinically significant portal hypertension (CSPH) by TE should be used to evaluate clinical applicability. In addition, certain limitations of TE, e.g. the influence of sex, age, etiology and levels of aminotransferases levels have to be considered. Methods: Retrospective analysis of the 717 measurements of LS performed in 559 patients evaluated at the hepatic hemodynamic laboratory. 88 sequential HVPG measurements with and without vasactive treatment with betablockers were performed. 175 transjugular liver biopsies were obtained. Demographic patient data were documented. Results: A significant correlation of LS and HVPG was noted (R=0.795; p 7.2kPa; p=0.03), 0.0694 for F3 (>9.6kPa; p=0.004) and 0.904 for F4 (12.1kPa; p=0.0001), respectively. Using a cut-off at 12.1kPa the PPV and NPV for diagnosis of F4 were 77% and 91%. Conclusions: Poor PPV and NPV limit the diagnostic use of TE for discriminating patients with and without CSPH. The better correlation of LS and HVPG under vasoactive medication may reflect the fact that TE is not assessing the dynamic component of portal hypertension. TE is able to exclude the diagnosis of histological cirrhosis with a NPV of 91%.

Published
2010
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48. M1380 Clinical and Morphological Elements Influencing Health Related Quality of Life (Assessed by Sf-36 Health Survey Questionnaire) in Patients With Chonic Pancreatitis

Author

A. Tudora, Mirela Danila, Ioan Sporea, and Octavian Paul Ciof

Subjects
Health related quality of life, medicine.medical_specialty, Hepatology, SF-36, business.industry, Family medicine, Gastroenterology, Health survey, Medicine, Pancreatitis, In patient, business, medicine.disease
Published
2010
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50. T1205 How Relevant is Acoustic Radiation Force Impulse Elastography (ARFI) for the Evaluation of Liver Fibrosis?

Author

Roxana Sirli, Ioan Sporea, Simona Bota, Mirela Danila, and Alina Popescu

Subjects
Pathology, medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Rectum, Inflammation, medicine.disease, Ulcerative colitis, digestive system diseases, Nitric oxide, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, medicine, Immunohistochemistry, Radiology, Elastography, medicine.symptom, Kinase activity, Signal transduction, business
Abstract

Background & Aims: The most striking clinical difference between ulcerative colitis (UC) and Crohn's disease (CD) is that in CD there is discontinuity of inflammation, with ulcers being scattered throughout the gut, surrounded by apparently normal mucosa (so called skip lesions), whereas UC presents as a continuous colonic inflammation, ascending from the rectum. Although recent data from GenomeWide Association studies have increased our knowledge on the genetic basis of these diseases the signalling pathways especially with regard to these skip lesions remain poorly understood. In order to reveal the signal transduction pathways involved we aimed to generate comprehensive descriptions of mucosal kinase activity. Methods: Paired biopsies of inflamed and non-inflamed colonic mucosa were analyzed on novel peptide arrays exhibiting > 1000 pseudo substrates to characterize mucosal kinase activity in Toto. Results were compared to colonic biopsies obtained from non-IBD patients and validated using conventional biochemistry and immunohistochemistry. Results: Inflamed mucosa of Crohn's disease patients displays strong activation of the NF-kB pathway, STAT-related signalling, nitric oxide signalling and very strong activation of p21Rac-related signalling. In contrast, p21Rac signalling in the non-inflamed mucosa of CD patients is highly suppressed. Conclusions: Our results show that the non-inflamed mucosa in CD is highly different from the mucosa of non-IBD patients in its very active suppression of A G A A b st ra ct s

Published
2010
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