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Your search keyword '"First in human"' showing total 11 results
Start Over Descriptor "First in human" Journal gastroenterology
11 results on '"First in human"'

2. Sa1762 - First-In-Human Study of the Novel 5-HT2B Receptor Antagonist, Rq-00310941, Demonstrated Safety and Tolerability Both in Healthy Subjects and Ulcerative Colitis Patients, with Improvement of a Sense of Abnormal Bowel Movement

Author

Akemi Ando, Hiroaki Zai, and Nobuaki Sato

Subjects
0301 basic medicine, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Healthy subjects, Antagonist, First in human, medicine.disease, Ulcerative colitis, 5-HT2B receptor, 03 medical and health sciences, 030104 developmental biology, Tolerability, Internal medicine, Sense (molecular biology), medicine, Defecation, business
Published
2018

3. Sa1093 - A First-In-Human, Open-Label, Healthy Volunteer Study of the New P-Cab X842 Demonstrating 24H Acid Control for Treatment of Acid Related Diseases

Author

Kjell Andersson and P. Unge

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, First in human, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Healthy volunteers, medicine, 030211 gastroenterology & hepatology, Open label, business
Published
2018

4. 1139 Endoscopic Dual-Path Enteral Anastomosis Using Self-Assembling Magnets: First-in-Human Clinical Feasibility

Author

David B. Lautz, Christopher C. Thompson, Marvin Ryou, Marek Buzga, and Evzen Machytka

Subjects
Hepatology, business.industry, Gastroenterology, First in human, DUAL (cognitive architecture), Anastomosis, Topology, Enteral administration, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Magnet, Self assembling, Path (graph theory), Medicine, 030211 gastroenterology & hepatology, business
Published
2016

5. 1141 Procedure Safety From First-in-Human Study of Duodenal Mucosal Resurfacing as a New Endoscopic Treatment for Type 2 Diabetes

Author

Patricia Rodriguez, James E. Coad, Colleen Beatty, Manoel Galvao Neto, Christopher C. Thompson, Leonardo Rodriguez, J. Nicholas Rubenstein, and Pablo Becerra

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Type 2 diabetes, First in human, medicine.disease, Surgery, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Medicine, 030211 gastroenterology & hepatology, business, Endoscopic treatment
Published
2016

6. 829 Endoscopic Duodenal Mucosal Resurfacing Improves Glycemic and Hepatic Parameters in Patients With Type 2 Diabetes: Data From a First-in-Human Study

Author

Harith Rajagopalan, Patricia Rodriguez, Pablo Becerra, Leonardo Rodriguez, Manoel Galvao Neto, Paulina Vignolo, and Jay Caplan

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, 030209 endocrinology & metabolism, First in human, Type 2 diabetes, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, 030211 gastroenterology & hepatology, In patient, business, Glycemic
Published
2016

9. First in Human Study With a Novel Ingestible Electronic Drug Delivery and Monitoring Device: The Intellicap

Author

Frits Dijksman, Christoph Wanke, Peter J. van der Schaar, Jeff Shimizu, and Peter D. Siersema

Subjects
Drug, Hepatology, business.industry, Computer science, media_common.quotation_subject, Gastroenterology, First in human, Data logger, Drug delivery, Drug reservoir, Stepper motor, business, Computer hardware, media_common
Abstract

BACKGROUND: Highly predictable intraluminal delivery of drugs to a well-defined area of the gut may be beneficial for the development and testing of new drugs as well as for clinical use in luminal diseases of the gut and diseases requiring high drug concentrations in the portal system. We developed an ingestible electronic drug delivery and monitoring device, the IntelliCap, to meet these demands. The IntelliCap comprises a 300 μl drug reservoir, a pHand temperature sensor, a stepper motor, and a transceiver for 2-way real time wireless communication. Data are relayed via a data recorder to a computer. Changes in pH and temperature can be used to indicate the location of the IntelliCap in the gut and control drug delivery.

Published
2011

10. 861 Safety and Efficacy of Pf-00547,659, a Fully Human Anti-MAdCAM Antibody, in Ulcerative Colitis. Results of a First in Human Study

Author

Jana Sirotiakova, Andreas Luegering, J. Spanton, Severine Vermeire, Ulrike Strauch, Jens Frederik Dahlerup, Wojciech Niezychowski, Subrata Ghosh, Gary Craig Burgess, and Julián Panés

Subjects
Hepatology, biology, business.industry, Immunology, Gastroenterology, Addressin, biology.protein, medicine, First in human, Antibody, medicine.disease, business, Ulcerative colitis
Published
2009

11. W1042 Mechanistic Population Pharmacokinetics (PK) Model of PF-00547659, a Fully Human IgG2 Anti-MAdCAM Antibody, in Ulcerative Colitis Patients: Results of a First in Human (Fih) Study

Author

Wojciech Niezychowski, Gary Craig Burgess, Steven W. Martin, Ivan T. Matthews, and Matts O. Magnusson

Subjects
Hepatology, biology, business.industry, Gastroenterology, First in human, Population pharmacokinetics, medicine.disease, Ulcerative colitis, Immunology, biology.protein, medicine, Addressin, Antibody, business
Published
2009

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