1. Single-Cell RNA Sequencing of Blood and Ileal T Cells From Patients With Crohn's Disease Reveals Tissue-Specific Characteristics and Drug Targets
- Author
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Klaas Nico Faber, Arnau Vich Vila, Gerard Dijkstra, Bernadien H. Jansen, Ramnik J. Xavier, Cisca Wijmenga, Rinse K. Weersma, Bana Jabri, Werna T. Uniken Venema, Michiel Voskuil, Daniel B. Graham, Gerben van der Vries, Eleonora A. M. Festen, Center for Liver, Digestive and Metabolic Diseases (CLDM), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Translational Immunology Groningen (TRIGR), Department of Health and Life Sciences, and Groningen Institute for Organ Transplantation (GIOT)
- Subjects
Adult ,Male ,T-Lymphocytes ,Cell ,Genome-wide Association Study ,LOCI ,Inflammatory bowel disease ,Article ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Crohn Disease ,Ileum ,Gene expression ,medicine ,Genetics ,T helper 17 cell ,Cytotoxic T cell ,Humans ,Collagenases ,Molecular Targeted Therapy ,Intestinal Mucosa ,Immune Response ,Cells, Cultured ,Edetic Acid ,030304 developmental biology ,GENE-EXPRESSION ,RISK ,0303 health sciences ,Crohn's disease ,Hepatology ,business.industry ,Sequence Analysis, RNA ,Inflammatory Bowel Disease ,Gastroenterology ,RNA ,Middle Aged ,medicine.disease ,Molecular biology ,Treatment Outcome ,medicine.anatomical_structure ,Female ,030211 gastroenterology & hepatology ,Colitis, Ulcerative ,business ,INFLAMMATORY-BOWEL-DISEASE - Published
- 2019