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Start Over Author "Colantoni A" Journal gastroenterology
27 results on '"Colantoni A"'

4. Dipotassium Glycyrrhizate Modulates Genes with a Key Role in Mucosal Healing in Mice with a DSS-Induced Colitis and Improves in vitro Epithelial Barrier Functions

Author

Anna Dilillo, Maria Pierdomenico, Manuela Costanzo, Francesca Palone, Eleonora Colantoni, Salvatore Cucchiara, Laura Stronati, Roberta Vitali, and Salvatore Oliva

Subjects
Epithelial barrier, Hepatology, business.industry, Gastroenterology, medicine.disease, In vitro, Mucosal healing, Immunology, Dipotassium Glycyrrhizate, medicine, Cancer research, Colitis, business, Gene
Published
2017

6. RIP3, A Regulator of Necroptosis, Promotes Inflammation by Increasing Cytokine and Inflammasome Molecule Levels as Well as Altering Membrane Permeability in Intestinal Epithelial CellS

Author

Colantoni, Eleonora, primary, Negroni, Anna, additional, Cesi, Vincenzo, additional, Palone, Francesca, additional, Costanzo, Manuela, additional, Viola, Franca, additional, Oliva, Salvatore, additional, Cucchiara, Salvatore, additional, and Stronati, Laura, additional

Published
2017
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8. RIP3, A Regulator of Necroptosis, Promotes Inflammation by Increasing Cytokine and Inflammasome Molecule Levels as Well as Altering Membrane Permeability in Intestinal Epithelial CellS

Author

Laura Stronati, Maria Pierdomenico, Anna Negroni, Eleonora Colantoni, Vincenzo Cesi, Saverio Mallardo, Francesca Palone, Salvatore Cucchiara, and Manuela Costanzo

Subjects
0301 basic medicine, Hepatology, Membrane permeability, business.industry, Chemistry, Necroptosis, medicine.medical_treatment, Gastroenterology, Regulator, Inflammation, Inflammasome, Cell biology, 03 medical and health sciences, 030104 developmental biology, Cytokine, medicine, medicine.symptom, business, medicine.drug
Published
2017

9. Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection

Author

Ivan Monteleone, S. Battista, Alfredo Colantoni, Luigi Giusto Spagnoli, Giovanna Del Vecchio Blanco, Marco Romano, Thomas T. MacDonald, Giampiero Palmieri, Giovanni Monteleone, Melissa Borrelli, Francesco Pallone, P. Vavassori, G., Monteleone, G., DEL VECCHIOBLANCO, G., Palmieri, P., Vavassori, I., Monteleone, A., Colantoni, S., Battista, Lg, Spagnoli, Romano, Marco, M., Borreli, Tt, Macdonald, and F., Pallone

Subjects
antisense oligonucleotide, Male, Pathology, cell maturation, stomach biopsy, Western blotting, mucosa cell, Interferon, Transforming Growth Factor beta, cytokine, Phosphorylation, pathophysiology, stomach mucosa, Settore MED/12 - Gastroenterologia, amoxicillin, integumentary system, biology, medicine.diagnostic_test, Th1 cell, Helicobacter pylori, Interferon-gamma, Smad3 Protein, DNA-Binding Proteins, Humans, Aged, Helicobacter Infections, T-Box Domain Proteins, Transforming Growth Factor beta1, Transcription Factors, Down-Regulation, Adult, Gastric Mucosa, Smad7 Protein, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Trans-Activators, Organ Culture Techniques, Signal Transduction, Female, Stomach, article, Gastroenterology, gene control, clarithromycin, gene induction, medicine.anatomical_structure, priority journal, gamma interferon, omeprazole, protein inhibitor, Smad3 protein, Smad7 protein, STAT1 protein, transforming growth factor beta1, adult, aged, cell isolation, cytokine production, enzyme linked immunosorbent assay, female, gastritis, Helicobacter infection, human, major clinical study, male, protein expression, protein phosphorylation, signal transduction, Interferon Type II, Gastritis, medicine.symptom, medicine.drug, medicine.medical_specialty, Inflammation, Settore MED/08 - Anatomia Patologica, Biopsy, Gastric mucosa, medicine, Hepatology, Cancer, biology.organism_classification, medicine.disease, Immunology
Abstract

Background & Aims: Helicobacter pylori ( Hp ) infection causes a chronic gastric inflammation, which can lead to peptic ulceration and cancer. The inflammatory response is multifactorial and is characterized by exaggerated Th1 cytokine production. How the Th1 response is induced and maintained in the stomach of Hp -infected patients remains unclear. Transforming growth factor (TGF)-β1 negatively regulates Th1 cell development, and TGF-β1-deficient mice spontaneously develop gastritis. Here, we examined TGF-β1 signaling in Hp -associated gastritis. Methods: Gastric biopsy specimens taken from patients with or without Hp infection were analyzed for the content of activated TGF-β1 by ELISA and Smad3 and 7 expression by Western blotting. Induction of Smad7 by interferon (IFN)-γ was examined in normal gastric mucosal biopsy specimens, whereas the effect of Smad7 inhibition on the ongoing Th1 response was analyzed in Hp -colonized biopsy specimens. Results: Activated TGF-β1 was abundant in the mucosa of controls and Hp -infected patients, with no significant difference between the 2 groups. Despite this, in whole biopsy specimens and isolated mucosal cells from Hp -infected patients, there was defective TGF-β1-associated Smad3 phosphorylation, which was associated with high expression of the inhibitor Smad7. Blocking Smad7 with antisense oligonucleotides restored TGF-β1 signaling in biopsy specimens from Hp -infected patients and concomitantly reduced interferon-γ and T-bet. Smad7 was inducible in normal gastric biopsy specimens by interferon-γ through a STAT1-dependent mechanism, and neutralization of interferon-γ in biopsy specimens from Hp -infected patients reduced Smad7 expression. Conclusions: These data suggest that, in Hp -infected gastric mucosa, interferon-γ induces the expression of Smad7, which then prevents endogenous TGF-β1 from down-regulating the ongoing tissue-damaging Th1 response.

Published
2004

12. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis

Author

Giampiero Palmieri, Daniele Fina, Giovanni Monteleone, Mariarosaria Marinaro, Ivan Monteleone, Massimo Sanchez, Alfredo Colantoni, Francesco Pallone, Claudia Di Giacinto, Monica Boirivant, Warren Strober, Roberta Caruso, and Thomas T. MacDonald

Subjects
antisense oligonucleotide, Male, Oligonucleotides, Mice, SCID, Inflammatory bowel disease, Western blotting, Oxazolone, chemistry.chemical_compound, Mice, Interferon, T lymphocyte, Inbred BALB C, Settore MED/12 - Gastroenterologia, Mice, Inbred BALB C, integumentary system, drug effect, article, single drug dose, Gastroenterology, protein function, Colitis, Blot, priority journal, hapten, oxazolone, Female, medicine.symptom, down regulation, medicine.drug, Signal Transduction, animal experiment, Down-Regulation, Inflammation, Biology, SCID, animal tissue, Smad7 Protein, Transforming Growth Factor beta1, medicine, Animals, controlled study, Smad3 Protein, Antisense, protein expression, mouse, Smad3 protein, Smad7 protein, transforming growth factor beta1, trinitrobenzenesulfonic acid, animal model, colitis, disease model, drug efficacy, enzyme linked immunosorbent assay, male, nonhuman, signal transduction, treatment outcome, Disease Models, Animal, Gene Expression Regulation, Oligonucleotides, Antisense, Trinitrobenzenesulfonic Acid, Hepatology, Animal, Oligonucleotide, medicine.disease, Molecular biology, chemistry, Disease Models, Cancer research, Transforming growth factor
Abstract

Background & Aims: Defective transforming growth factor (TGF)-β1 signaling due to high levels of Smad7 is a feature of inflammatory bowel disease (IBD). In this study, we analyzed the effect of reducing Smad7 levels with antisense oligonucleotide on mouse models of colitis. Methods: Mucosal samples taken from colitic tissue of mice with colitis due to either haptenating reagents (trinitrobenzene sulfonic acid [TNBS] or oxazolone) or to transfer of T cells (SCID transfer colitis) were analyzed for Smad3 and/or Smad7 expression by Western blotting and, in some cases, content of TGF-β1 by enzyme-linked immunosorbent assay. The effect of oral Smad7 antisense oligonucleotide on mucosal inflammation was assessed. Results: TGF-β1 levels were increased in the inflamed tissues of mice with colitis induced by either TNBS or oxazolone. Nevertheless, TGF-β1 did not exert a regulatory effect, probably because TGF-β1 signaling was blocked, as indicated by the presence of reduced Smad3 phosphorylation and high levels of Smad7. Oral administration of Smad7 antisense oligonucleotide to colitic mice restored TGF-β1 signaling via Smad3 and ameliorated inflammation in hapten-induced colitis. In addition, Smad7 antisense oligonucleotide had a therapeutic effect on relapsing TNBS-induced colitis but not on cell-transfer colitis. Conclusions: These data suggest that colitis models associated with high endogenous TGF-β1 levels and defective TGF-β1 signaling due to high levels of Smad7 can be ameliorated by down-regulation of Smad7 and by oral administration of Smad7 antisense oligonucleotide. This may represent a new approach to the control of IBD, particularly during active phases when its Smad7 profile resembles that of hapten-induced colitis.

Published
2006

13. Su1856 TH17-Related Cytokines and Excessive Activation of STAT3 Sustain Colorectal Cancer Cell Growth

Author

De Simone, Veronica, primary, Franzè, Eleonora, additional, Ronchetti, Giulia, additional, Colantoni, Alfredo, additional, Fantini, Massimo C., additional, Di Fusco, Davide, additional, Sica, Giuseppe, additional, Sileri, Pierpaolo, additional, Thomas, MacDonald, additional, Pallone, Francesco, additional, Monteleone, Giovanni, additional, and Stolfi, Carmine, additional

Published
2014
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16. Su1856 TH17-Related Cytokines and Excessive Activation of STAT3 Sustain Colorectal Cancer Cell Growth

Author

Eleonora Franzè, Massimo Fantini, Davide Di Fusco, Veronica De Simone, Carmine Stolfi, Giuseppe S. Sica, G. Ronchetti, Francesco Pallone, Pierpaolo Sileri, Giovanni Monteleone, MacDonald Thomas, and Alfredo Colantoni

Subjects
Oncology, medicine.medical_specialty, Hepatology, biology, Colorectal cancer, business.industry, Cell growth, Gastroenterology, medicine.disease, Internal medicine, medicine, Cancer research, biology.protein, STAT3, business
Published
2014

17. Sa1998 Innate Lymphoid Cells Are Increased in Celiac Disease Intestinal Mucosa and Have a Pathogenic Role in a Mouse Model of Small Intestine Atrophy

Author

Ivan Monteleone, Alfredo Colantoni, Angela Ortenzi, Francesco Pallone, Maria Laura Cupi, Omero Alessandro Paoluzi, Giovanni Monteleone, Giuseppe S. Sica, and Irene Marafini

Subjects
Pathology, medicine.medical_specialty, Hepatology, Innate lymphoid cell, Gastroenterology, Disease, Biology, medicine.disease, Small intestine, medicine.anatomical_structure, Atrophy, Intestinal mucosa, Immunology, medicine
Published
2014

19. Inhibition of Smad7 With a Specific Antisense Oligonucleotide Facilitates TGF-β1–Mediated Suppression of Colitis

Author

Boirivant, Monica, primary, Pallone, Francesco, additional, Di Giacinto, Claudia, additional, Fina, Daniele, additional, Monteleone, Ivan, additional, Marinaro, Mariarosaria, additional, Caruso, Roberta, additional, Colantoni, Alfredo, additional, Palmieri, Giampiero, additional, Sanchez, Massimo, additional, Strober, Warren, additional, MacDonald, Thomas T., additional, and Monteleone, Giovanni, additional

Published
2006
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20. Induction and regulation of Smad7 in the gastric mucosa of patients with Helicobacter pylori infection

Author

Monteleone, Giovanni, primary, Del Vecchio Blanco, Giovanna, additional, Palmieri, Giampiero, additional, Vavassori, Piero, additional, Monteleone, Ivan, additional, Colantoni, Alfredo, additional, Battista, Serena, additional, Spagnoli, Luigi Giusto, additional, Romano, Marco, additional, Borrelli, Melissa, additional, MacDonald, Thomas T., additional, and Pallone, Francesco, additional

Published
2004
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23. Prevalence of HCV infection after heart transplant

Author

Fagiuoli, S., primary, Jazzar, A., additional, DeMaria, N., additional, Faruki, H., additional, Deal, S., additional, Hassanein, T., additional, Colantoni, A., additional, Sisson, S., additional, Tripp, J., additional, Gavaler, J.S., additional, van Thiel, DH, additional, Cooper, DKC, additional, and Zuhdi, N., additional

Published
1995
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24. High plasma levels of atrial natriuteric peptide (ANP) in pre-ascitic cirrhosis: Evidence of renal hyposensitivity to the peptide

Author

Antonio Gasbarrini, Paola Emanuela D'Intino, Franco Trevisani, Mauro Bernardi, R. De Jaso, Alessandra Colantoni, G. Sica, S. De Notaris, A. Barbieri, and G. Gasbarrini

Subjects
chemistry.chemical_classification, medicine.medical_specialty, Cirrhosis, Hepatology, business.industry, Gastroenterology, Peptide, medicine.disease, Endocrinology, chemistry, High plasma, Internal medicine, medicine, business
Published
1995

25. Prevalence of HCV infection after heart transplant

Author

N. Zuhdi, H. Faruki, J. Tripp, Tarek Hassanein, N. DeMaria, A. Jazzar, Alessandra Colantoni, D. H. Van Thiel, Stefano Fagiuoli, J. S. Gavaler, S. Sisson, Dkc Cooper, and Stephen R. Deal

Subjects
Hepatology, Gastroenterology
Published
1995

26. Clinico-pathologic features of hepatocellular carcinoma (HCC) in Western Children and Adolescents

Author

Paolo Caraceni, Alessandra Colantoni, Gian Luca Grazi, Antonio Gasbarrini, S. De Notaris, A. Mazziotti, Giuseppe Gozzetti, Franco Trevisani, Paola Emanuela D'Intino, G. Gasbarrini, Mauro Bernardi, and M. Pizzo

Subjects
Pathology, medicine.medical_specialty, Hepatology, business.industry, Hepatocellular carcinoma, Gastroenterology, medicine, medicine.disease, business
Published
1995

27. Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.

Author

Boirivant M, Pallone F, Di Giacinto C, Fina D, Monteleone I, Marinaro M, Caruso R, Colantoni A, Palmieri G, Sanchez M, Strober W, MacDonald TT, and Monteleone G

Subjects
Animals, Colitis chemically induced, Colitis genetics, Disease Models, Animal, Down-Regulation, Female, Gene Expression Regulation drug effects, Male, Mice, Mice, Inbred BALB C, Mice, SCID, Oligonucleotides, Antisense therapeutic use, Signal Transduction genetics, Smad3 Protein genetics, Smad3 Protein metabolism, Smad7 Protein genetics, Transforming Growth Factor beta1 genetics, Trinitrobenzenesulfonic Acid, Colitis metabolism, Colitis prevention & control, Oligonucleotides, Antisense pharmacology, Smad7 Protein metabolism, Transforming Growth Factor beta1 metabolism
Abstract

Background & Aims: Defective transforming growth factor (TGF)-beta1 signaling due to high levels of Smad7 is a feature of inflammatory bowel disease (IBD). In this study, we analyzed the effect of reducing Smad7 levels with antisense oligonucleotide on mouse models of colitis., Methods: Mucosal samples taken from colitic tissue of mice with colitis due to either haptenating reagents (trinitrobenzene sulfonic acid [TNBS] or oxazolone) or to transfer of T cells (SCID transfer colitis) were analyzed for Smad3 and/or Smad7 expression by Western blotting and, in some cases, content of TGF-beta1 by enzyme-linked immunosorbent assay. The effect of oral Smad7 antisense oligonucleotide on mucosal inflammation was assessed., Results: TGF-beta1 levels were increased in the inflamed tissues of mice with colitis induced by either TNBS or oxazolone. Nevertheless, TGF-beta1 did not exert a regulatory effect, probably because TGF-beta1 signaling was blocked, as indicated by the presence of reduced Smad3 phosphorylation and high levels of Smad7. Oral administration of Smad7 antisense oligonucleotide to colitic mice restored TGF-beta1 signaling via Smad3 and ameliorated inflammation in hapten-induced colitis. In addition, Smad7 antisense oligonucleotide had a therapeutic effect on relapsing TNBS-induced colitis but not on cell-transfer colitis., Conclusions: These data suggest that colitis models associated with high endogenous TGF-beta1 levels and defective TGF-beta1 signaling due to high levels of Smad7 can be ameliorated by down-regulation of Smad7 and by oral administration of Smad7 antisense oligonucleotide. This may represent a new approach to the control of IBD, particularly during active phases when its Smad7 profile resembles that of hapten-induced colitis.

Published
2006
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