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17 results on '"Clara Yzet"'

2. Deep Remission at 1 Year Prevents Progression of Early Crohn's Disease

Author

Olga Prymak, Grażyna Rydzewska, Per M. Hellström, Silvio Danese, Geert R. D'Haens, David Laharie, Gottfried Novacek, Mathurin Fumery, Mélanie Serrero, Erik Hertervig, Xavier Hébuterne, Peter Bossuyt, Remo Panaccione, Mircea Diculescu, Vincent W. Joustra, Benjamin Pariente, Jean-Frederic Colombel, J Butler, Walter Reinisch, Clara Yzet, Laurent Peyrin-Biroulet, Marc Ferrante, Francesca Petralia, Thomas Vanasek, Fernando Gomollón, Oleksandr Golovchenko, J Petersson, Jonas Halfvarson, Filip Baert, John P. Wright, Simon Travis, Gerhard Rogler, Adrian Goldis, Ryan C. Ungaro, Alessandro Armuzzi, Carol Stanciu, Irina Gubonina, Satoshi Motoya, Stefan Schreiber, Ungaro, Ryan C, Yzet, Clara, Bossuyt, Peter, Baert, Filip J, Vanasek, Thoma, D'Haens, Geert R, Joustra, Vincent Wilhelmu, Panaccione, Remo, Novacek, Gottfried, Reinisch, Walter, Armuzzi, Alessandro, Golovchenko, Oleksandr, Prymak, Olga, Goldis, Adrian, Travis, Simon P, Hébuterne, Xavier, Ferrante, Marc, Rogler, Gerhard, Fumery, Mathurin, Danese, Silvio, Rydzewska, Grazyna, Pariente, Benjamin, Hertervig, Erik, Stanciu, Carol, Serrero, Melanie, Diculescu, Mircea, Peyrin-Biroulet, Laurent, Laharie, David, Wright, John P, Gomollón, Fernando, Gubonina, Irina, Schreiber, Stefan, Motoya, Satoshi, Hellström, Per M, Halfvarson, Jona, Butler, James W, Petersson, Joel, Petralia, Francesca, Colombel, Jean-Frederic, Gastroenterology and Hepatology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Time Factors, IBD, Anti-Inflammatory Agents, Lower risk, Severity of Illness Index, Article, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Crohn Disease, Interquartile range, Internal medicine, Azathioprine, Medicine, Humans, Retrospective Studies, Crohn's disease, Hepatology, business.industry, Proportional hazards model, Tumor Necrosis Factor-alpha, Hazard ratio, Remission Induction, Gastroenterology, Adalimumab, medicine.disease, Inflammatory Bowel Diseases, Crohn's Disease Activity Index, Confidence interval, Hospitalization, 030104 developmental biology, Treatment Outcome, Disease Progression, Prednisone, 030211 gastroenterology & hepatology, Drug Therapy, Combination, Female, Calprotectin, CDEIS, business, Follow-Up Studies
Abstract

BACKGROUND & AIMS: We investigated the effects of inducing deep remission in patients with early Crohn's disease (CD). METHODS: We collected follow-up data from 122 patients (mean age, 31.2 ± 11.3 y) with early, moderate to severe CD (median duration, 0.2 years; interquartile range, 0.1-0.5) who participated in the Effect of Tight Control Management on CD (CALM) study, at 31 sites, representing 50% of the original CALM patient population. Fifty percent of patients (n = 61) were randomly assigned to a tight control strategy (increased therapy based on fecal level of calprotectin, serum level of C-reactive protein, and symptoms), and 50% were assigned to conventional management. We categorized patients as those who were vs were not in deep remission (CD endoscopic index of severity scores below 4, with no deep ulcerations or steroid treatment, for 8 or more weeks) at the end of the follow-up period (median, 3.02 years; range, 0.05-6.26 years). The primary outcome was a composite of major adverse outcomes that indicate CD progression during the follow-up period: new internal fistulas or abscesses, strictures, perianal fistulas or abscesses, or hospitalization or surgery for CD. Kaplan-Meier and penalized Cox regression with bootstrapping were used to compare composite rates between patients who achieved or did not achieve remission at the end of the follow-up period. RESULTS: Major adverse outcomes were reported for 34 patients (27.9%) during the follow-up period. Significantly fewer patients in deep remission at the end of the CALM study had major adverse outcomes during the follow-up period (P = .01). When we adjusted for potential confounders, deep remission (adjusted hazard ratio, 0.19; 95% confidence interval, 0.07-0.31) was significantly associated with a lower risk of major adverse outcome. CONCLUSIONS: In an analysis of follow-up data from the CALM study, we associated induction of deep remission in early, moderate to severe CD with decreased risk of disease progression over a median time of 3 years, regardless of tight control or conventional management strategy. ispartof: GASTROENTEROLOGY vol:159 issue:1 pages:139-147 ispartof: location:United States status: published

Published
2019

3. Sa1788 LOW LEVELS OF VITAMIN D AND OSTEOPENIA ARE COMMON IN ULCERATIVE COLITIS PATIENTS AFTER TOTAL PROCTOCOLECTOMY WITH ILEAL POUCH ANAL ANASTOMOSIS

Author

Clara Yzet, Anam Rizvi, Maia Kayal, Sergey Khaitov, Patricia Sylla, Parth D. Trivedi, Alexander Greenstein, Ariel Bar-Mashiah, Michael Plietz, and Marla Dubinsky

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine.disease, Ulcerative colitis, Ileal Pouch Anal Anastomosis, Osteopenia, Total Proctocolectomy, Internal medicine, medicine, Vitamin D and neurology, business
Published
2020

4. Su1912 CDEIS SCORE OF 2 IS OPTIMAL CUT-OFF ASSOCIATED WITH LOWER RISK OF DISEASE PROGRESSION IN EARLY CROHN'S DISEASE: DATA FROM THE CALM STUDY

Author

Mathurin Fumery, Mélanie Serrero, Tomas Vanasek, Benjamin Pariente, Satoshi Motoya, John P. Wright, Filip Baert, Clara Yzet, Robyn Jordan, Mircea Diculescu, Stefan Schreiber, Jonas Halfvarson, Oleksandr Golovchenko, Peter Bossuyt, Vincent W. Joustra, Remo Panaccione, Irina Gubonina, Per M. Hellström, Silvio Danese, Geert R. D'Haens, Gottfried Novacek, Grazyna Rydzewska-Wyszkowska, David Laharie, Simon Travis, Gerhard Rogler, Ryan C. Ungaro, Erik Hertervig, Adrian Goldis, Laurent Peyrin-Biroulet, Xavier Hébuterne, Marc Ferrante, Carol Stanciu, Walter Reinisch, Jean-Frederic Colombel, Prymak Olga, Alessandro Armuzzi, and Fernando Gomollón

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Internal medicine, Disease progression, Gastroenterology, Medicine, business, Lower risk, medicine.disease
Published
2020

8. Mo1844 – Long-Term Fate of the Excluded Rectum in Crohn’s Disease

Author

Nilendra Nair, Clara Yzet, Jean-Frederic Colombel, David B. Sachar, and Gasan Kassim

Subjects
medicine.medical_specialty, Crohn's disease, medicine.anatomical_structure, Hepatology, business.industry, Internal medicine, Gastroenterology, Medicine, Rectum, business, medicine.disease, Term (time)
Published
2019

9. 110 – Stopping 5-Aminosalicylates in Crohn's Disease Patients Starting Biologic Therapy Does Not Increase the Risk of Adverse Clinical Outcomes: Analysis of Two Nationwide Population-Based Cohorts

Author

Manasi Agrawal, Kristine H. Allin, Ryan C. Ungaro, Johan Burisch, Jean-Frederic Colombel, Clara Yzet, Thomas A. Ullman, Berkeley N. Limketkai, Tine Jess, and Camilla B. Jensen

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Outcome analysis, Population based, medicine.disease, business
Published
2019

10. Sa1812 – Endoscopic and Deep Remission At 1 Year Prevents Disease Progression in Early Crohn's Disease: Long-Term Data from Calm

Author

John P. Wright, David Laharie, Laurent Peyrin-Biroulet, Marc Ferrante, Fernando Gomollón, Mircea Diculescu, Satoshi Motoya, Stefan Schreiber, Irina Gubonina, Per M. Hellström, Silvio Danese, Jean-Charles Grimaud, Gerhard Rogler, Tomas Vanasek, Geert R. D'Haens, Mathurin Fumery, Adrian Goldis, Gottfried Novacek, Alessandro Armuzzi, Grażyna Rydzewska, Jean-Frederic Colombel, Benjamin Pariente, Jonas Halfvarson, Peter Bossuyt, Oleksandr Golovchenko, Erik Hertervig, Remo Panaccione, Xavier Hébuterne, Vincent W. Joustra, Carol Stanciu, Prymak Olga, Filip Baert, Simon Travis, Ryan C. Ungaro, and Clara Yzet

Subjects
Crohn's disease, Pediatrics, medicine.medical_specialty, Hepatology, business.industry, Long term data, Disease progression, Gastroenterology, medicine, medicine.disease, business
Published
2019

12. Mo1806 – Endoscopic Pouch Activity in Asymptomatic Patients with an Ileal Pouch Anal Anastomosis is Associated with an Increased Risk of Future Pouchitis

Author

Benjamin L. Cohen, Jean-Frederic Colombel, Anam Rizvi, Clara Yzet, Marla Dubinsky, Michael Plietz, Robert Hirten, Ryan C. Ungaro, Maia Kayal, and Marlana Radcliffe

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Pouchitis, medicine.disease, Asymptomatic, Surgery, Ileal Pouch Anal Anastomosis, Increased risk, medicine, medicine.symptom, Pouch, business
Published
2019

15. Su1891 - Long-Term Natural History of Microscopic Colitis: A Population-Based Study

Author

Dana Duricova, Guillaume Savoye, Eric Nguyen-Khan, Julien Loreau, Franck Brazier, Mathurin Fumery, Hélène Sarter, Clara Yzet, Jean-Louis Dupas, Denis Chatelain, and Corinne Gower-Rousseau

Subjects
Population based study, Natural history, medicine.medical_specialty, Microscopic colitis, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, medicine.disease, business, Term (time)
Published
2018

16. What is the Best definition of Mucosal Healing in Crohn Disease?

Author

Jean-Philippe Lemouel, Mathurin Fumery, Eric Nguyen-Khan, Julien Loreau, Jean-Louis Dupas, Franck Brazier, and Clara Yzet

Subjects
medicine.medical_specialty, Hepatology, business.industry, Crohn disease, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Mucosal healing, medicine, 030211 gastroenterology & hepatology, business
Published
2017

17. Evaluation of the Diagnostic and Prognostic Value of Procalcitonin in Acute Colitis

Author

Franck Brazier, Eric Nguyen-Khan, Adrien Wacrenier, Justine Turpin, Mathurin Fumery, Jérôme Ausseil, Clara Yzet, Vincent Hautefeuille, and Jean-Louis Dupas

Subjects
medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, business, Value (mathematics), Acute colitis, Procalcitonin
Published
2017

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