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11 results on '"Attali, Pierre"'

1. Validation of Baveno VI Criteria for Screening and Surveillance of Esophageal Varices in Patients With Compensated Cirrhosis and a Sustained Response to Antiviral Therapy

Author

Nahon, Pierre, Marcellin, Patrick, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Larrey, Dominique, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Zarski, Jean-Pierre, Leroy, Vincent, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Serfaty, Lawrence, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Bacq, Yannick, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Capron, Dominique, Thiefin, Gérard, Hillaire, Sophie, Di Martino, Vincent, Bureau, Christophe, Layese, Richard, Bourcier, Valérie, Hammouche, Maryam, Cagnot, Carole, Goria, Odile, Wartelle-Bladou, Claire, Bernard-Chabert, Brigitte, Sutton, Angela, Audureau, Etienne, and Roudot-Thoraval, Françoise

Published
2019
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2. Incidence of Hepatocellular Carcinoma After Direct Antiviral Therapy for HCV in Patients With Cirrhosis Included in Surveillance Programs

Author

Nahon, Pierre, Marcellin, Patrick, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Larrey, Dominique, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Zarski, Jean-Pierre, Leroy, Vincent, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Serfaty, Lawrence, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Bacq, Yannick, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Nguyen-Khac, Eric, Bernard-Chabert, Brigitte, Hillaire, Sophie, Di Martino, Vincent, Layese, Richard, Bourcier, Valérie, Cagnot, Carole, Zucman, David, Sutton, Angela, Roudot-Thoraval, Françoise, and Audureau, Etienne

Published
2018
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3. Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-Time Adjusted Survival of Patients With Compensated Viral Cirrhosis: A Multi-Center Cohort Study

Author

Nahon, Pierre, Marcellin, Patrick, Guyader, Dominique, Pol, Stanislas, Fontaine, Hélène, Larrey, Dominique, De Lédinghen, Victor, Ouzan, Denis, Zoulim, Fabien, Roulot, Dominique, Tran, Albert, Bronowicki, Jean-Pierre, Zarski, Jean-Pierre, Leroy, Vincent, Riachi, Ghassan, Calès, Paul, Péron, Jean-Marie, Alric, Laurent, Bourlière, Marc, Mathurin, Philippe, Dharancy, Sebastien, Blanc, Jean-Frédéric, Abergel, Armand, Serfaty, Lawrence, Mallat, Ariane, Grangé, Jean-Didier, Attali, Pierre, Bacq, Yannick, Wartelle, Claire, Dao, Thông, Thabut, Dominique, Pilette, Christophe, Silvain, Christine, Christidis, Christos, Capron, Dominique, Thiefin, Gérard, Hillaire, Sophie, Di Martino, Vincent, Costentin, Charlotte E., Layese, Richard, Bourcier, Valérie, Cagnot, Carole, Nguyen-khac, Eric, Bernard-Chabert, Brigitte, Zucman, David, Sutton, Angela, Letouzé, Eric, Imbeaud, Sandrine, Zucman-Rossi, Jessica, Audureau, Etienne, and Roudot-Thoraval, Françoise

Published
2018
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4. Validation of Baveno VI Criteria for Screening and Surveillance of Esophageal Varices in Patients With Compensated Cirrhosis and a Sustained Response to Antiviral Therapy

Author

Thabut, Dominique, primary, Bureau, Christophe, additional, Layese, Richard, additional, Bourcier, Valérie, additional, Hammouche, Maryam, additional, Cagnot, Carole, additional, Marcellin, Patrick, additional, Guyader, Dominique, additional, Pol, Stanislas, additional, Larrey, Dominique, additional, De Lédinghen, Victor, additional, Ouzan, Denis, additional, Zoulim, Fabien, additional, Roulot, Dominique, additional, Tran, Albert, additional, Bronowicki, Jean-Pierre, additional, Zarski, Jean-Pierre, additional, Goria, Odile, additional, Calès, Paul, additional, Péron, Jean-Marie, additional, Alric, Laurent, additional, Bourlière, Marc, additional, Mathurin, Philippe, additional, Blanc, Jean-Frédéric, additional, Abergel, Armand, additional, Serfaty, Lawrence, additional, Mallat, Ariane, additional, Grangé, Jean-Didier, additional, Attali, Pierre, additional, Bacq, Yannick, additional, Wartelle-Bladou, Claire, additional, Dao, Thông, additional, Pilette, Christophe, additional, Silvain, Christine, additional, Christidis, Christos, additional, Capron, Dominique, additional, Bernard-Chabert, Brigitte, additional, Hillaire, Sophie, additional, Di Martino, Vincent, additional, Sutton, Angela, additional, Audureau, Etienne, additional, Roudot-Thoraval, Françoise, additional, Nahon, Pierre, additional, Fontaine, Hélène, additional, Leroy, Vincent, additional, Riachi, Ghassan, additional, Dharancy, Sebastien, additional, Wartelle, Claire, additional, Thabut, Dominique, additional, and Thiefin, Gérard, additional

Published
2019
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5. Compliance With Hepatocellular Carcinoma Surveillance Guidelines Associated With Increased Lead-Time Adjusted Survival of Patients With Compensated Viral Cirrhosis: A Multi-Center Cohort Study

Author

Costentin, Charlotte E., primary, Layese, Richard, additional, Bourcier, Valérie, additional, Cagnot, Carole, additional, Marcellin, Patrick, additional, Guyader, Dominique, additional, Pol, Stanislas, additional, Larrey, Dominique, additional, De Lédinghen, Victor, additional, Ouzan, Denis, additional, Zoulim, Fabien, additional, Roulot, Dominique, additional, Tran, Albert, additional, Bronowicki, Jean-Pierre, additional, Zarski, Jean-Pierre, additional, Riachi, Ghassan, additional, Calès, Paul, additional, Péron, Jean-Marie, additional, Alric, Laurent, additional, Bourlière, Marc, additional, Mathurin, Philippe, additional, Blanc, Jean-Frédéric, additional, Abergel, Armand, additional, Serfaty, Lawrence, additional, Mallat, Ariane, additional, Grangé, Jean-Didier, additional, Attali, Pierre, additional, Bacq, Yannick, additional, Wartelle, Claire, additional, Dao, Thông, additional, Thabut, Dominique, additional, Pilette, Christophe, additional, Silvain, Christine, additional, Christidis, Christos, additional, Nguyen-khac, Eric, additional, Bernard-Chabert, Brigitte, additional, Zucman, David, additional, Di Martino, Vincent, additional, Sutton, Angela, additional, Letouzé, Eric, additional, Imbeaud, Sandrine, additional, Zucman-Rossi, Jessica, additional, Audureau, Etienne, additional, Roudot-Thoraval, Françoise, additional, Nahon, Pierre, additional, Fontaine, Hélène, additional, Leroy, Vincent, additional, Dharancy, Sebastien, additional, Capron, Dominique, additional, Thiefin, Gérard, additional, and Hillaire, Sophie, additional

Published
2018
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6. Eradication of Hepatitis C Virus Infection in Patients With Cirrhosis Reduces Risk of Liver and Non-Liver Complications

Author

Nahon, Pierre, primary, Bourcier, Valérie, additional, Layese, Richard, additional, Audureau, Etienne, additional, Cagnot, Carole, additional, Marcellin, Patrick, additional, Guyader, Dominique, additional, Fontaine, Hélène, additional, Larrey, Dominique, additional, De Lédinghen, Victor, additional, Ouzan, Denis, additional, Zoulim, Fabien, additional, Roulot, Dominique, additional, Tran, Albert, additional, Bronowicki, Jean-Pierre, additional, Zarski, Jean-Pierre, additional, Leroy, Vincent, additional, Riachi, Ghassan, additional, Calès, Paul, additional, Péron, Jean-Marie, additional, Alric, Laurent, additional, Bourlière, Marc, additional, Mathurin, Philippe, additional, Dharancy, Sébastien, additional, Blanc, Jean-Frédéric, additional, Abergel, Armand, additional, Serfaty, Lawrence, additional, Mallat, Ariane, additional, Grangé, Jean-Didier, additional, Attali, Pierre, additional, Bacq, Yannick, additional, Wartelle, Claire, additional, Dao, Thông, additional, Benhamou, Yves, additional, Pilette, Christophe, additional, Silvain, Christine, additional, Christidis, Christos, additional, Capron, Dominique, additional, Bernard-Chabert, Brigitte, additional, Zucman, David, additional, Di Martino, Vincent, additional, Thibaut, Vincent, additional, Salmon, Dominique, additional, Ziol, Marianne, additional, Sutton, Angela, additional, Pol, Stanislas, additional, Roudot-Thoraval, Françoise, additional, Nahon, Pierre, additional, Thiefin, Gérard, additional, and Hillaire, Sophie, additional

Published
2017
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7. Effectiveness of Telaprevir or Boceprevir in Treatment-Experienced Patients With HCV Genotype 1 Infection and Cirrhosis

Author

Hézode, Christophe, primary, Fontaine, Helene, additional, Dorival, Celine, additional, Zoulim, Fabien, additional, Larrey, Dominique, additional, Canva, Valerie, additional, De Ledinghen, Victor, additional, Poynard, Thierry, additional, Samuel, Didier, additional, Bourliere, Marc, additional, Alric, Laurent, additional, Raabe, Jean–Jacques, additional, Zarski, Jean–Pierre, additional, Marcellin, Patrick, additional, Riachi, Ghassan, additional, Bernard, Pierre–Henri, additional, Loustaud–Ratti, Veronique, additional, Chazouilleres, Olivier, additional, Abergel, Armand, additional, Guyader, Dominique, additional, Metivier, Sophie, additional, Tran, Albert, additional, Di Martino, Vincent, additional, Causse, Xavier, additional, Dao, Thong, additional, Lucidarme, Damien, additional, Portal, Isabelle, additional, Cacoub, Patrice, additional, Gournay, Jerome, additional, Grando–Lemaire, Veronique, additional, Hillon, Patrick, additional, Attali, Pierre, additional, Fontanges, Thierry, additional, Rosa, Isabelle, additional, Petrov–Sanchez, Ventzislava, additional, Barthe, Yoann, additional, Pawlotsky, Jean–Michel, additional, Pol, Stanislas, additional, Carrat, Fabrice, additional, and Bronowicki, Jean–Pierre, additional

Published
2014
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8. Hereditary persistence of α-fetoprotein is due to both proximal and distal hepatocyte nuclear factor-1 site mutations 1 1The authors thank Dr. A. Chauchereau for the gift of A9TKCAT vector, Dr. O. Lahuna for helpful discussion, C. Aumas for excellent technical assistance, and S. Wenk for careful English proofreading of the text. We are grateful for the cooperation of the patients and their families.

Author

Alj, Youssef, primary, Georgiakaki, Maria, additional, Savouret, Jean-François, additional, Mal, FrÉdÉric, additional, Attali, Pierre, additional, Pelletier, Gilles, additional, Fourré, Catherine, additional, Milgrom, Edwin, additional, Buffet, Catherine, additional, Guiochon-Mantel, Anne, additional, and Perlemuter, Gabriel, additional

Published
2004
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10. Hereditary persistence of α-fetoprotein is due to both proximal and distal hepatocyte nuclear factor-1 site mutations11The authors thank Dr. A. Chauchereau for the gift of A9TKCAT vector, Dr. O. Lahuna for helpful discussion, C. Aumas for excellent technical assistance, and S. Wenk for careful English proofreading of the text. We are grateful for the cooperation of the patients and their families.

Author

Alj, Youssef, Georgiakaki, Maria, Savouret, Jean-François, Mal, FrÉdÉric, Attali, Pierre, Pelletier, Gilles, Fourré, Catherine, Milgrom, Edwin, Buffet, Catherine, Guiochon-Mantel, Anne, and Perlemuter, Gabriel

Abstract

Background & Aims:The molecular mechanism of hereditary persistence of α-fetoprotein (HPAFP) has been previously described in a large Scottish family, consisting of a −119G>A substitution in the distal hepatocyte nuclear factor 1 (HNF-1) binding site of the α-fetoprotein (AFP) gene promoter. We report here the molecular mechanisms of HPAFP in 2 new unrelated families. Methods:Family 1 was of Bengali origin, and family 2 was Italian. Four of 5 subjects (family 1) and 3 of 9 (family 2) showed HPAFP. The AFP gene promoter was studied in all available family members. Results:All subjects with high AFP levels had mutated promoter sequences. Family 1 showed the reported −119G>A substitution. Family 2 showed −55C>A and −65C>T substitutions in the proximal putative HNF-1 binding region of the promoter. The −55C>A mutation increased the similarity of the proximal HNF-1 binding region to a consensus binding region. Gel shift assays confirmed its increased affinity toward HNF-1, and transfection experiments revealed an increased level of gene transcription. The −65C>T substitution theoretically created a CCAAT box. However, gel shift and transfection experiments failed to show any biological effect of this substitution that is associated with the −55C>A mutation. Conclusions:Two different mutations localized in either HNF-1 binding sites of the AFP gene promoter may result in HPAFP. This highlights the importance of HNF-1 in AFP gene expression. Unexplained persistent AFP should lead to family study and/or AFP gene promoter sequencing to avoid inappropriate explorations and treatment decisions.

Published
2004
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11. Hereditary persistence of alpha-fetoprotein is due to both proximal and distal hepatocyte nuclear factor-1 site mutations.

Author

Alj Y, Georgiakaki M, Savouret JF, Mal F, Attali P, Pelletier G, Fourré C, Milgrom E, Buffet C, Guiochon-Mantel A, and Perlemuter G

Subjects
Base Sequence genetics, Binding Sites genetics, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Hepatocyte Nuclear Factor 1-beta, Humans, Male, Middle Aged, Molecular Sequence Data, Pedigree, Promoter Regions, Genetic genetics, Promoter Regions, Genetic physiology, DNA-Binding Proteins, Mutation physiology, Nuclear Proteins, Transcription Factors metabolism, alpha-Fetoproteins genetics, alpha-Fetoproteins metabolism
Abstract

Background and Aims: The molecular mechanism of hereditary persistence of alpha-fetoprotein (HPAFP) has been previously described in a large Scottish family, consisting of a -119G>A substitution in the distal hepatocyte nuclear factor 1 (HNF-1) binding site of the alpha-fetoprotein (AFP) gene promoter. We report here the molecular mechanisms of HPAFP in 2 new unrelated families., Methods: Family 1 was of Bengali origin, and family 2 was Italian. Four of 5 subjects (family 1) and 3 of 9 (family 2) showed HPAFP. The AFP gene promoter was studied in all available family members., Results: All subjects with high AFP levels had mutated promoter sequences. Family 1 showed the reported -119G>A substitution. Family 2 showed -55C>A and -65C>T substitutions in the proximal putative HNF-1 binding region of the promoter. The -55C>A mutation increased the similarity of the proximal HNF-1 binding region to a consensus binding region. Gel shift assays confirmed its increased affinity toward HNF-1, and transfection experiments revealed an increased level of gene transcription. The -65C>T substitution theoretically created a CCAAT box. However, gel shift and transfection experiments failed to show any biological effect of this substitution that is associated with the -55C>A mutation., Conclusions: Two different mutations localized in either HNF-1 binding sites of the AFP gene promoter may result in HPAFP. This highlights the importance of HNF-1 in AFP gene expression. Unexplained persistent AFP should lead to family study and/or AFP gene promoter sequencing to avoid inappropriate explorations and treatment decisions.

Published
2004
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