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Your search keyword '"Adriaan P. de Bruïne"' showing total 13 results
Start Over Author "Adriaan P. de Bruïne" Journal gastroenterology
13 results on '"Adriaan P. de Bruïne"'

4. S1758 Loss of the Guardians at the Intestinal Barrier: Paneth Cell Apoptosis as a New Phenomenon in Human Intestinal Ischemia-Induced Bacterial Translocation

Author

Jacco-Juri de Haan, Adriaan P. de Bruïne, Ronald M. van Dam, Caroline M. Hodin, Joep Grootjans, Wim A. Buurman, Cornelis H. C. Dejong, Kaatje Lenaerts, Joep P. M. Derikx, and M'hamed Hadfoune

Subjects
medicine.anatomical_structure, Hepatology, Apoptosis, Intestinal ischemia, Paneth cell, Gastroenterology, medicine, Bacterial translocation, Biology, Cell biology
Published
2010
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6. 600 Are Hyperplastic Polyps Precursors of Colorectal Cancer? A Long-Term, Retrospective Study

Author

Bjorn Winkens, Silvia Sanduleanu, Ad A.M. Masclee, Eveline Rondagh, Ann Driessen, Mariëlle Bouwens, and Adriaan P. de Bruïne

Subjects
Oncology, medicine.medical_specialty, Hepatology, Hyperplastic Polyp, business.industry, Colorectal cancer, Internal medicine, Gastroenterology, Medicine, Retrospective cohort study, business, medicine.disease, Term (time)
Published
2009
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7. S1964 Higher Prevalence of CpG Island Methylator Phenotype-Positive (CIMP+) Status in Advanced Adenomas Detected Using Colonoscopy for Colorectal Cancer (CRC) Screening

Author

Carolina A.J. Khalid-de Bakker, Ad A.M. Masclee, Daisy Jonkers, Reinhold W. Stockbrügger, Kim M. Smits, Manon van Engeland, Adriaan P. de Bruïne, and Wim Hameeteman

Subjects
Oncology, medicine.medical_specialty, Hepatology, CpG Island Methylator Phenotype, medicine.diagnostic_test, business.industry, Colorectal cancer, Advanced adenomas, Crc screening, Gastroenterology, Colonoscopy, medicine.disease, Internal medicine, medicine, business
Published
2009
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9. W1874 Promoter Hypermethylation of PHACTR3, a Potential New Biomarker for Colorectal Cancer Detection

Author

Frank A. Oort, Daisy Jonkers, Adriaan P. de Bruïne, Maarten Neerincx, Manon van Engeland, Sandra Mongera, Ad A.M. Masclee, Chris J. J. Mulder, Carolina A.J. Khalid-de Bakker, Gerrit A. Meijer, Beatriz Carvalho, Katja Bierau, Joost Louwagie, Linda J.W. Bosch, and Wim Van Criekinge

Subjects
Oncology, medicine.medical_specialty, Hepatology, Promoter hypermethylation, business.industry, Colorectal cancer, Internal medicine, Gastroenterology, Medicine, Biomarker (medicine), business, medicine.disease
Published
2009
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10. An Inactivating Mutation in HDAC2 Leads to Dysregulation of Apoptosis Mediated by APAF1

Author

James G. Herman, Matty P. Weijenberg, James R. Eshleman, Adriaan P. de Bruïne, Manon van Engeland, Christin L. Hanigan, and Kim A.D. Wouters

Subjects
Hepatology, Gastroenterology, Biology, Molecular biology, Chromatin, Frameshift mutation, Trichostatin A, Histone, DNA methylation, medicine, Cancer research, biology.protein, Epigenetics, Histone deacetylase, Chromatin immunoprecipitation, medicine.drug
Abstract

Background & Aims Histone deacetylases (HDACs) are important regulators of chromatin involved in silencing tumor suppressor genes. We examined mutation of HDAC2 and examined consequences of HDAC2 loss. Methods Colon cancer cell lines and primary cancers were examined for mutations in HDAC2 by direct sequencing and capillary electrophoresis. Promoter methylation was determined using methylation-specific polymerase chain reaction in primary tumors. Sensitivity to HDAC inhibitors and resistance in vitro used colon cancer cell lines. Results HDAC2 mutations in the poly(A) tract in exon 1 result in a frameshift and premature stop codon. These were found in microsatellite instability (MSI) cell lines and 43% of MSI colon cancers, but only 7% of microsatellite stable cancers. Mutation was associated with complete or regional tumor specific loss of HDAC2 protein. Inactivation of HDAC2 was not associated with large-scale changes in promoter region methylation, but rather is a consequence of epigenetic MLH1 inactivation leading to MSI. HDAC2 mutation results in apoptotic resistance to HDAC inhibitors (trichostatin A or suberoylanilide hydroxamic acid), despite induction of global histone acetylation. Differential induction of apoptosis by HDAC inhibitors is mediated by the proapoptotic gene APAF1 , as shown by specific APAF1 induction only in cell lines with functional HDAC2, HDAC2 protein localization to the APAF1 promoter by chromatin immunoprecipitation, siRNA knockdown of HDAC2 leading to up-regulation of APAF1 , and stable knockdown of APAF1 reducing apoptotic response to HDAC inhibitors. Conclusions Frequent HDAC2 mutations are found in MSI tumors and HDAC2 plays a major role in mediating apoptotic response to HDAC inhibitors through direct regulation of APAF1.

Published
2008
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11. T1116 High Prevalence of Small Adenomas in a Colorectal Cancer Screening Population Using Primary Colonoscopy

Author

Daisy Jonkers, Silvia Sanduleanu, Adriaan P. de Bruïne, Carolina A.J. Khalid-de Bakker, Reinhold W. Stockbrügger, Ad A.M. Masclee, and Wim Hameeteman

Subjects
Oncology, medicine.medical_specialty, education.field_of_study, High prevalence, Hepatology, medicine.diagnostic_test, business.industry, Colorectal cancer, Population, Gastroenterology, Colonoscopy, medicine.disease, Colorectal cancer screening, Internal medicine, medicine, education, business
Published
2008
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13. Mucosal capillary thrombi in steroid refractory ulcerative colitis: Influence of low molecular weight heparin (LMWH) treatment

Author

Anton A. Vrji, Jeroen M. Jansen, Adriaan P. de Bruïne, and Reinhold W. Stockbrügger

Subjects
medicine.medical_specialty, Hepatology, medicine.drug_class, business.industry, Internal medicine, Gastroenterology, medicine, Low molecular weight heparin, Steroid refractory, business, medicine.disease, Ulcerative colitis
Published
2000
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