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Your search keyword '"Yuriko, Koike"' showing total 2 results
Start Over Author "Yuriko, Koike" Journal gastroenterologia japonica
2 results on '"Yuriko, Koike"'

1. HBs-Ag, HBc-Ag and virus-like particles in liver tissue

Author

Seiichi Furuta, Atsuo Nagata, Kendo Kiyosawa, Toshihiro Takahashi, Yoshihiro Akahane, Yuriko Koike, Takeshi Sahara, Yoshihiro Iijima, Kenichi Furukawa, Tomoyuki Watanabe, Masako Hara, Akihiko Omori, and Masayuki Oda

Subjects
Adult, Male, medicine.medical_specialty, Pathology, Hepatitis B virus, viruses, Biology, medicine.disease_cause, Virus, law.invention, Liver disease, Antigen, Virus-like particle, law, Internal medicine, medicine, Humans, Cell Nucleus, Hepatitis B Surface Antigens, Gastroenterology, virus diseases, Middle Aged, medicine.disease, Molecular biology, Hepatitis B Core Antigens, digestive system diseases, medicine.anatomical_structure, Liver, Cytoplasm, Hepatocyte, Female, Electron microscope
Abstract

Hepatitis B surface antigen (HBs-Ag) and hepatitis B core antigen (HBc-Ag) in hepatic tissue of 3 cases with various liver diseases were investigated by immunofluorescent method. Virus-like particles were demonstrated by electron microscopy in the nuclei of these 3 cases. The localization of HBs-Ag was restricted in cytoplasma or on the surface of hepatocyte, while HBc-Ag was almost in the hepatocytic nuclei. However, there was unexplainable discrepancy between the distribution of HBs-Ag and that of HBc-Ag, as more the former in number and less that latter, of hepatocytes. The size of virus-like particles in nuclei was 22-27 nm in diameter. Most of them were hollow, but some of them were wholly electron dense. Their distribution was various from case to case. Discussion was made on the correlation between the presence of Hepatitis B virus and HBs-Ag or HBc-Ag.

Published
1975

2. Clinical significance of e-antigen/anti-e, with special reference to HBc-antigen in the liver

Author

Fumio Tsuda, Seiichi Furuta, Makoto Mayumi, Yoshihiro Akahane, Kenziro Kawahara, Ken Sodeyama, Yoshihiro Iijima, Masazumi Miura, Hironao Komatsu, Masayuki Oda, Kenichi Furukawa, Kendo Kiyosawa, Atsuo Nagata, Shinkichi Yamamura, Yuriko Koike, Yukio Gibo, and Takeshi Sahara

Subjects
Adult, medicine.medical_specialty, Cirrhosis, Antibodies, Viral, Asymptomatic, Hepatitis B Antigens, Antigen, Internal medicine, Medicine, Humans, Hepatitis B Antibodies, Hepatitis, biology, business.industry, Liver Diseases, Gastroenterology, Hepatology, medicine.disease, Hepatitis B, Hepatitis B Core Antigens, digestive system diseases, Titer, Liver, Immunology, Carrier State, biology.protein, medicine.symptom, Antibody, business, Asymptomatic carrier
Abstract

e-antigen and anti-e were assayed in sera of asymptomatic HBs-Ag carriers and of patients with liver diseases. Thirteen out of 34 (38.2%) asymptomatic carriers were positive for e-antigen, which was in sharp contrast to the reports from USA and Europe. e-antigen was detected to a greater extent in patients with chronic active hepatitis, reversely anti-e in patients with chronic persistent hepatitis. However, e-antigen was found rarely in patients with cirrhosis and never in 23 cases with hepatoma positive for HBs-Ag. HBc-Ag in the liver was detected in 4 out of 8 e-antigen positive asymptomatic carriers and in 4 out of 5 patients with chronic liver diseases with e-antigen respectively, and moreover in 3 out of 14 anti-e positive cases, so that the presence of anti-e did not necessarily mean the negativity of HBc-Ag in the liver. Anti-HBc titer, however, was lower in anti-e positive sera than in e-antigen positive ones. This may implicate the decreased replication of HBV in cases with anti-e. These results emphasize that the investigation of e-antigen/anti-e is mandatory for the evaluation of the prognosis of asymptomatic carriers and of patients with chronic hepatitis.

Published
1977

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