1. [The relationship between gene expression of Bcl-2 and Bax and the therapeutic effect in oral cancer patients].
- Author
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Oshikawa T, Okamoto M, Ahmed SU, Tano T, and Sato M
- Subjects
- Antineoplastic Combined Chemotherapy Protocols therapeutic use, Gene Expression, Humans, Interferon-gamma blood, Killer Cells, Natural cytology, Mouth Neoplasms mortality, Picibanil administration & dosage, Survival Rate, Tegafur therapeutic use, Uracil therapeutic use, Genes, bcl-2 genetics, Mouth Neoplasms genetics, Mouth Neoplasms therapy, bcl-2-Associated X Protein genetics
- Abstract
We have investigated the relationship between gene expression of Bcl 2 and Bax and the therapeutic effect in oral cancer patients. A significant correlation between Bcl-2/Bax gene expression ratio in the peripheral blood mononuclear cells (PBMCs) from the patients, and the therapeutic effect of radiation therapy in combination with UFT and OK-432, as well as survival rate, was observed. In addition, the statistically significant correlation was also observed between Bcl-2/Bax ratio and IFN-gamma and NK activity induced with OK-432. These findings suggest that Bcl-2 and Bax gene expression in PBMCs may be useful as a prognostic factor in oral cancer patients.
- Published
- 2006