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This study is concerned with the concept of Ensemble Fuzzy Radial Basis Function Neural Networks (EFRBFNN) endowed with clustering techniques, polynomial-based LSE/WLSE learning as well as their optimization implemented by Multi-Objective Particle Swarm Optimization (MOPSO). The network architecture of the proposed EFRBFNN classifier is considered three types of clustering techniques and four forms of regression polynomials. The proposed classifier can not only fully capture the local distribution (feature) information contained in the data, but also choose effective network architecture for improving classification performance and compactness. Three classes of clustering techniques (such as iterative self-organizing data analysis techniques algorithm (ISODATA), affinity propagation (AP), and extended K-means) are considered to effectively produce membership degrees based on feature information extraction suitable to fit data characteristics. Least Square Error Estimation (LSE) and Weighted Least Square Error Estimation (WLSE)-based learning with four types of regression polynomials are considered to estimate to coefficients of polynomials. MOPSO is exploited for choosing the effective architecture among different clustering techniques, polynomials, and polynomial-based learning with multi-objective parametric optimization. MOPSO helps achieve a sound compromise between the preferred classification performance and the compactness realized with the aid of four objective functions such as a) classification accuracy (CA), b) complexity of clustering, c) complexity of polynomial and d) sum of squared coefficients (SSC). The improvement and effectiveness of the proposed network architecture are quantified on a basis of the comprehensive experimental results and also a comparative analysis is offered to demonstrate the superiority of the proposed classifier. [ABSTRACT FROM AUTHOR]