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Recently, the polynomial-based radial basis function neural networks (P-RBFNNs) have been successfully applied to regression tasks. However, the redundant and non-linear partitioned data easily interfere with accurate partitioning of clusters completed in P-RBFNNs, affecting the regression performance of this existing model. Because the squared error is used as the cost function of the learning method, P-RBFNNs are sensitive to noise interference. In order to cope with these problems, this study introduces a double iterative learning-based polynomial based-RBFNNs (DP-RBFNNs) modeling that focuses on the formation of architectures to improve the accuracy of regression performance as well as enhance the robustness through double iterative learning as follows: a) support vector-based Gaussian kernel fuzzy c-means (SV-GKFCM) as a kind of the support vector-based kernel fuzzy clustering are designed to determine connections (weights) between the input and hidden layers of the proposed model. SV-GKFCM helps effectively reduce the number of redundant data to re-modify the partitioning of clusters in the DP-RBFNNs. In addition, the cluster centers can be accurately updated from the non-linear partitioned data with the aid of Gaussian kernel distance in SV-GKFCM; b) least absolute shrinkage deviations (LASD) as a robust estimation are designed to update connection weights between the hidden and output layers. The SAE (sum of absolute error) function in the LASD method is used as a cost function to reduce the noise interference in the procedure of weight estimation as well as enhance the robustness of the DP-RBFNNs. The superiority of the proposed model is demonstrated through the experimental results. [ABSTRACT FROM AUTHOR]