1. Is there a role for carbon therapy in the treatment of gynecological carcinomas? A systematic review
- Author
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Yichao Geng, Xueshan Zhao, Shuangwu Feng, Chengcheng Li, Juntao Ran, Qiuning Zhang, Xiaohu Wang, and Lina Wang
- Subjects
0301 basic medicine ,Carbon therapy ,Oncology ,Cancer Research ,medicine.medical_specialty ,Genital Neoplasms, Female ,Heavy Ion Radiotherapy ,03 medical and health sciences ,0302 clinical medicine ,Concurrent chemotherapy ,Internal medicine ,medicine ,Humans ,Surgical treatment ,Clinical Trials as Topic ,Genitourinary system ,business.industry ,Melanoma ,Disease Management ,General Medicine ,medicine.disease ,Clinical trial ,030104 developmental biology ,Treatment Outcome ,030220 oncology & carcinogenesis ,Carbon ion therapy ,Carbon Ion Radiotherapy ,Female ,business - Abstract
This Systematic Review summarizes the literatures of clinical trials on the efficacy and safety of carbon ion therapy for gynecological carcinomas. The protocol is detailed in the online PROSPERO database, registration no. CRD42019121424, and a final set of eight studies were included. In the treatment of cervical carcinomas, both carbon ion therapy alone and carbon ion therapy concurrent chemotherapy have presented good efficacy. Besides, the efficacy of inoperable endometrial carcinomas and gynecological melanoma are similar to that of surgical treatment. In terms of safety, gastrointestinal and genitourinary toxicities are low and could be controlled by limiting the volume and dose of intestinal tract and bladder. Carbon ion radiotherapy could be considered a safe, effective and feasible therapy for gynecological carcinomas.
- Published
- 2019