1. Linkage disequilibrium and haplotype analysis ofSrcandYes1genes in thyroid cancer
- Author
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Ishrat Mahjabeen, Asif Nisar, Khalida Khurshid, Malik Waqar Ahmed, Mahmood Akhtar Kayani, and Azhar Mehmood
- Subjects
0301 basic medicine ,Oncology ,Cancer Research ,medicine.medical_specialty ,Linkage disequilibrium ,business.industry ,Haplotype ,Single-nucleotide polymorphism ,General Medicine ,medicine.disease ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,Genotype ,medicine ,business ,Gene ,Thyroid cancer ,Proto-oncogene tyrosine-protein kinase Src ,SNP array - Abstract
Purpose: This study was planned to examine the effects of Src and Yes1 single nucleotide polymorphism (SNPs) on the risk of thyroid cancer in 499 patients and 500 controls. Materials & methods: Three SNPs of Src gene and three SNPs of Yes1 gene were analyzed using Tetra-primer ARMS-PCR followed by sequencing. Results: rs121913314 of Src gene genotype TT showed 32-fold increased risk of thyroid cancer and rs2305994 of Yes1 genotypes TT and CT showed 2.7-fold and 16-fold increased risk in thyroid cancer (p < 0.0001). Haplotype analysis revealed that CATGCC, CATGCT, CATGTC, CATGTT, TATGCC and TATGTTA haplotypes are associated with thyroid cancer risk. Conclusion: Results showed that genotypes and allele distribution of Src and Yes1 genes are significantly linked with increased risk of thyroid cancer.
- Published
- 2020
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