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Your search keyword '"Penders, John"' showing total 7 results
Start Over Author "Penders, John" Journal future microbiology
7 results on '"Penders, John"'

2. In VitroMucin Degradation and Paracellular Permeability by Fecal water from Crohn’s Disease Patients

Author

Becker, Heike EF, Kameli, Nader, Rustichelli, Alice, Heijnens, Britt AM, Stassen, Frank RM, Penders, John, and Jonkers, Daisy MAE

Abstract

Aim:This study aimed to examine the impact of fecal water (FW) of active and remissive Crohn’s disease (CD) patients on mucin degradation and epithelial barrier function. Methods:FW and bacterial membrane vesicles (MVs) were isolated from fresh fecal samples of six healthy controls (HCs) and 12 CD patients. Bacterial composition was determined by 16S rRNA gene amplicon sequencing. Results:In vitroFW-induced mucin degradation was higher in CD samples versus HC (p < 0.01), but not associated with specific bacterial genera. FW of three remissive samples decreased transepithelial electrical resistance in Caco-2 cells by 78–87% (p < 0.001). MVs did not induce barrier alterations. Conclusion:The higher mucin-degradation capacity of CD-derived FW might suggest contributions of microbial products to CD pathophysiology.

Published
2024
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6. Prolonged carriage and potential onward transmission of carbapenemase-producing Enterobacteriaceae in Dutch travelers

Author

van Hattem, Jarne M, primary, Arcilla, Maris S, additional, Bootsma, Martin CJ, additional, van Genderen, Perry J, additional, Goorhuis, Abraham, additional, Grobusch, Martin P, additional, Molhoek, Nicky, additional, Oude Lashof, Astrid ML, additional, Schultsz, Constance, additional, Stobberingh, Ellen E, additional, Verbrugh, Henri A, additional, de Jong, Menno D, additional, Melles, Damian C, additional, and Penders, John, additional

Published
2016
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