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Modern ICT infrastructures, i.e., cyber-physical systems and critical infrastructures relying on interconnected IT (Information Technology)- and OT (Operational Technology)-based components and (sub-)systems, raise complex challenges in tackling security and safety issues. Nowadays, many security controls and mechanisms have been made available and exploitable to solve specific security needs, but, when dealing with very complex and multifaceted heterogeneous systems, a methodology is needed on top of the selection of each security control that will allow the designer/maintainer to drive her/his choices to build and keep the system secure as a whole, leaving the choice of the security controls to the last step of the system design/development. This paper aims at providing a comprehensive methodological approach to design and preliminarily implement an Open Platform Architecture (OPA) to secure the cyber-physical systems of critical infrastructures. Here, the Open Platform Architecture (OPA) depicts how an already existing or under-design target system (TS) can be equipped with technologies that are modern or currently under development, to monitor and timely detect possibly dangerous situations and to react in an automatic way by putting in place suitable countermeasures. A multifaceted use case (UC) that is able to show the OPA, starting from the security and safety requirements to the fully designed system, will be developed step by step to show the feasibility and the effectiveness of the proposed methodology.