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Your search keyword '"A. G. Marrosu"' showing total 1 results
Start Over Author "A. G. Marrosu" Journal functional neurology
1 results on '"A. G. Marrosu"'

1. Paradoxical reactions elicited by diazepam in children with classic autism

Author

F, Marrosu, G, Marrosu, M G, Rachel, and G, Biggio

Subjects
Aggression, Male, Diazepam, Attention Deficit Disorder with Hyperactivity, Humans, Female, Autistic Disorder, Child, Receptors, GABA-A
Abstract

Administration of diazepam (10 mg i.m.) to seven children (two girls and five boys) affected by infantile autism elicited paradoxical behavioural responses. Mainly, anxiogenic effect, unsocialized aggressive behaviour and explosive aggression were dramatically increased in comparison with the same symptoms present before and after treatment. The results show for the first time that benzodiazepines may elicit paradoxical behavioural response in autistic children. The possible involvement of an altered function at the level of GABA/benzodiazepine receptor complex is discussed.

Published
1987

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