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Start Over Author "Eric A. Richard" Journal frontiers in veterinary science
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1. Asymmetrical Pulmonary Cytokine Profiles Are Linked to Bronchoalveolar Lavage Fluid Cytology of Horses With Mild Airway Neutrophilia

Author

Erika Hue, Marie Orard, Marie-Pierre Toquet, Marianne Depecker, Anne Couroucé, Stéphane Pronost, Romain Paillot, and Eric A. Richard

Subjects
horse, equine asthma, bronchoalveolar lavage fluid, neutrophils, IL-10, IL-1β, Veterinary medicine, SF600-1100
Abstract

Few data on cytokine profiles in bronchoalveolar lavage fluid (BALF) are available for racehorses with mild/moderate equine asthma (EA); cytological diagnosis being most frequently made from only one lung. The purpose of the study was to compare cytokine mRNA expressions and protein concentrations in BALF from both lungs. As part of a larger study, 250 ml saline was randomly instilled in one lung and 500 ml in the contralateral lung of 30 clinically healthy Standardbred racehorses. This procedure was repeated 72 h later, inversing the volume per lung. Cytological cut-off values for diagnosis of mild EA was neutrophil proportions > 10% when instilling 250 ml. Eleven horses that exhibited unilateral mild inflammatory cytology [i.e., normal cytology (

Published
2020
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2. Asymmetrical Pulmonary Cytokine Profiles Are Linked to Bronchoalveolar Lavage Fluid Cytology of Horses With Mild Airway Neutrophilia

Author

Erika Hue, Marie Orard, Marie-Pierre Toquet, Marianne Depecker, Anne Couroucé, Stéphane Pronost, Romain Paillot, Eric A. Richard, Biologie, génétique et thérapies ostéoarticulaires et respiratoires (BIOTARGEN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO), Nutrition PhysioPathologie et Pharmacologie (NP3), and Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)

Subjects
medicine.medical_specialty, 040301 veterinary sciences, medicine.medical_treatment, Gastroenterology, equine asthma, 0403 veterinary science, 03 medical and health sciences, neutrophils, Cytology, Internal medicine, medicine, Saline, 030304 developmental biology, Original Research, 0303 health sciences, Lung, lcsh:Veterinary medicine, [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, bronchoalveolar lavage fluid, General Veterinary, medicine.diagnostic_test, business.industry, Horse, 04 agricultural and veterinary sciences, respiratory system, Neutrophilia, respiratory tract diseases, horse, Interleukin 10, Bronchoalveolar lavage, medicine.anatomical_structure, Cytokine, IL-1β, IL-10, lcsh:SF600-1100, Veterinary Science, medicine.symptom, business
Abstract

International audience; Few data on cytokine profiles in bronchoalveolar lavage fluid (BALF) are available for racehorses with mild/moderate equine asthma (EA); cytological diagnosis being most frequently made from only one lung. The purpose of the study was to compare cytokine mRNA expressions and protein concentrations in BALF from both lungs. As part of a larger study, 250 ml saline was randomly instilled in one lung and 500 ml in the contralateral lung of 30 clinically healthy Standardbred racehorses. This procedure was repeated 72h later, inversing the volume per lung. Cytological cut-off values for diagnosis of mild EA was neutrophils proportions > 10% when instilling 250 ml. Eleven horses that exhibited unilateral mild inflammatory cytology (i.e. normal cytology [

Published
2019

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