Search

Your search keyword '"Dijon Henrique Salomé de Campos"' showing total 2 results
Start Over Author "Dijon Henrique Salomé de Campos" Journal frontiers in physiology
2 results on '"Dijon Henrique Salomé de Campos"'

1. Effects of aerobic exercise on cardiac function and gene expression of NADPH oxidases in diaphragm muscle of rats with aortic stenosis-induced heart failure

Author

Mariana Janini Gomes, Ana Karenina Sabela, Isabele Tiburcio Pecin Ferreira, Sérgio Luiz Borges de Souza, Gustavo Augusto Ferreira Mota, Vitor Loureiro da Silva, Dijon Henrique Salomé de Campos, Aline Regina Ruiz Lima, Marianna Rabelo Carvalho, Silmeia Garcia Zanati Bazan, Camila Renata Corrêa, Antônio Carlos Cicogna, Marina Politi Okoshi, and Francis Lopes Pacagnelli

Subjects
aortic stenosis, heart failure, diaphragm, oxidative stress, aerobic physical exercise, Physiology, QP1-981
Abstract

We evaluated the influence of aerobic physical exercise (EX) on gene-encoding proteins associated with oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure (HF). Wistar male rats were divided into four groups: Control sedentary (C); Control exercise (C-Ex); Sedentary aortic stenosis (AS); Aortic stenosis exercise (AS-Ex). Exercised rats trained 5 times a week for 10 weeks on a treadmill. Statistical analysis was performed by ANOVA or Kruskal–Wallis test. In the final echocardiogram, animals with aortic stenosis subjected to exercise demonstrated improvement in systolic function compared to the sedentary aortic stenosis group. In diaphragm muscle, the activity of antioxidant enzymes, malondialdehyde malondialdehyde concentration, protein carbonylation, and protein expression of p65 and its inhibitor IκB did not differ between groups. Alterations in gene expression of sources that generate reactive species of oxygen were observed in AS-Ex group, which showed decreased mRNA abundance of NOX2 and NOX4 compared to the aortic stenosis group (p < 0.05). We concluded that aerobic exercise has a positive impact during heart failure, ameliorating systolic dysfunction and biomarkers of oxidative stress in diaphragm muscle of rats with aortic stenosis-induced heart failure.

Published
2023
Full Text
View/download PDF

2. Aerobic Exercise During Advance Stage of Uncontrolled Arterial Hypertension

Author

Antonio Carlos Cicogna, Katashi Okoshi, Ana Lloret, Ricardo Luiz Damatto, Tulio M. M. Caldonazo, Luana Urbano Pagan, Marcelo Diarcadia Mariano Cezar, Dijon Henrique Salomé de Campos, Ana Angélica Henrique Fernandes, Aline R. R. Lima, David Rafael Abreu Reyes, Denise C. Fernandes, Marina Politi Okoshi, Felipe C. Damatto, Francisco R.M. Laurindo, Bertha F. Polegato, Mariana Janini Gomes, Universidade Estadual Paulista (UNESP), FAIT, Universidade de São Paulo (USP), and INCLIVA

Subjects
medicine.medical_specialty, hypertension, Physiology, Physical exercise, heart, myocardium function, medicine.disease_cause, chemistry.chemical_compound, physical exercise, Physiology (medical), Internal medicine, Lactate dehydrogenase, Medicine, Aerobic exercise, Citrate synthase, QP1-981, cardiovascular diseases, Original Research, biology, business.industry, Malondialdehyde, medicine.disease, Endocrinology, chemistry, Heart failure, biology.protein, cardiovascular system, business, spontaneously hypertensive rats, Nicotinamide adenine dinucleotide phosphate, Oxidative stress
Abstract

Made available in DSpace on 2022-04-29T08:45:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-03 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Universidade Estadual Paulista Aim: To evaluate the influence of physical training on myocardial function, oxidative stress, energy metabolism, and MAPKs and NF-κB signaling pathways in spontaneously hypertensive rats (SHR), at advanced stage of arterial hypertension, which precedes heart failure development. Methods: We studied four experimental groups: normotensive Wistar rats (W, n = 27), trained W (W-EX, n = 31), SHR (n = 27), and exercised SHR (SHR-EX, n = 32). At 13 months old, the exercise groups underwent treadmill exercise 5 days a week for 4 months. In vitro myocardial function was analyzed in left ventricular (LV) papillary muscle preparations. Antioxidant enzyme activity and energy metabolism were assessed by spectrophotometry. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity was analyzed by lucigenin reduction and protein expression by Western blot. Statistical analyzes: ANOVA and Tukey or Kruskal–Wallis and Dunn tests. Results: SHR-EX had a lower frequency of heart failure features than SHR. Myocardial function and antioxidant enzyme activity were better in SHR-EX than SHR. Lipid hydroperoxide concentration, and phosphorylated JNK and total IkB protein expression were higher in hypertensive than control groups. Malondialdehyde, NADPH oxidase activity, total JNK, phosphorylated p38, phosphorylated and total p65 NF-κB, and phosphorylated IkB did not differ between groups. Protein expression from total p38, and total and phosphorylated ERK were higher in SHR than W. Lactate dehydrogenase and phosphorylated ERK were lower and citrate synthase and β-hydroxyacyldehydrogenase were higher in SHR-EX than SHR. Conclusion: Exercise improves physical capacity, myocardial function, and antioxidant enzyme activity; reduces the frequency of heart failure features and ERK phosphorylation; and normalizes energy metabolism in SHR. Botucatu Medical School UNESP Sao Paulo State University Itapeva Social and Agrarian Sciences College FAIT Department of Cardiopneumology Medical School University of Sao Paulo (USP) Institute of Biosciences Sao Paulo State University (UNESP) Freshage Research Group Department of Physiology University of Valencia CIBERFES INCLIVA Botucatu Medical School UNESP Sao Paulo State University Institute of Biosciences Sao Paulo State University (UNESP)

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results