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A study published in Frontiers in Pharmacology examines the effectiveness of a quadruplet regimen for newly diagnosed multiple myeloma (NDMM) patients. The study finds that while the quadruplet regimen is effective in the standard-risk subgroup of NDMM patients, it is not as effective in the high-risk subgroup. The study analyzes several clinical trials and concludes that triplet regimens are currently recommended as the initial treatment for NDMM, but quadruplet regimens may be a potential alternative for certain patients. The article discusses the use of quadruplet regimens for the treatment of newly diagnosed multiple myeloma (NDMM) patients. The article highlights that quadruplet regimens, which include anti-CD38 antibodies, have shown higher response rates, longer progression-free survival, and higher rates of minimal residual disease negativity compared to triplet regimens. However, the data on overall survival is limited, and the cost-effectiveness of quadruplet regimens needs to be considered, especially in developing countries. For high-risk NDMM patients, the efficacy of quadruplet regimens is still uncertain, and more evidence is needed to support their use. Overall, careful consideration is recommended when choosing quadruplet regimens as the first-line treatment for NDMM patients. This document is a list of references cited in an article published in Frontiers in Pharmacology. The article discusses various treatment regimens and therapies for newly diagnosed multiple myeloma, a type of cancer. The references include studies [Extracted from the article]

Hematologic malignancies (HMs), also referred to as hematological or blood cancers, pose significant threats to patients as they impact the blood, bone marrow, and lymphatic system. Despite significant clinical strategies using chemotherapy, radiotherapy, stem cell transplantation, targeted molecular therapy, or immunotherapy, the five-year overall survival of patients with HMs is still low. Fortunately, recent studies demonstrate that the nanodrug delivery system holds the potential to address these challenges and foster effective anti-HMs with precise treatment. In particular, cell membrane camouflaged nanodrug offers enhanced drug targeting, reduced toxicity and side effects, and/or improved immune response to HMs. This review firstly introduces the merits and demerits of clinical strategies in HMs treatment, and then summarizes the types, advantages, and disadvantages of current nanocarriers helping drug delivery in HMs treatment. Furthermore, the types, functions, and mechanisms of cell membrane fragments that help nanodrugs specifically targeted to and accumulate in HM lesions are introduced in detail. Finally, suggestions are given about their clinical translation and future designs on the surface of nanodrugs with multiple functions to improve therapeutic efficiency for cancers. [ABSTRACT FROM AUTHOR]

Background: Improve the treatment quality might affect patients' efficacy and survival. Methods: Five hundred thirty multiple myeloma patients treated in four hematological centers in China from February 2006 to August 2018 were enrolled. General characteristics, treatment regimens and cycles, efficacy, survival and adverse events of the patients treated before and after August 2013 (later refer to as the before-2013 and after-2013 group) were analyzed and compared. Results: The results suggested that patients who received optimized treatment regimen and route of administration completed more cycles of treatment in the after-2013 group. Although the overall response rate was similar between the two groups (88.6 vs. 90.5%), patients in the after-2013 group had higher complete remission rate (39.1 vs. 28.6%) and better progression-free survival. Subgroup analysis suggested that patients aged 65 years and older, with non-high-risk D-S, ISS, and R-ISS stages, had a significant benefit in progression-free survival. Conclusion: Therefore, in clinical practice in China, by reducing the economic burden brought by the treatment on patients and optimizing the treatment regimen, more patients can be treated with better regimens in a prolonged duration to achieve better efficacy and survival, especially in elderly and non-high-risk patients. [ABSTRACT FROM AUTHOR]