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Your search keyword '"Feng, Yuxin"' showing total 11 results
Start Over Author "Feng, Yuxin" Journal frontiers in pharmacology
11 results on '"Feng, Yuxin"'

1. ACT001 improved cardiovascular function in septic mice by inhibiting the production of proinflammatory cytokines and the expression of JAK-STAT signaling pathway

Author

Peng, Zhen, primary, Lv, Xiaolong, additional, Wang, Xintong, additional, Shang, Ting, additional, Chang, Jing, additional, Salahdiin, Khalid, additional, Guo, Yue, additional, Zhang, Zhisen, additional, Shen, Ru, additional, Lyu, Ming, additional, He, Shuang, additional, Yang, Jian, additional, Wang, Yuefei, additional, Gao, Xiumei, additional, Zhu, Yan, additional, and Feng, Yuxin, additional

Published
2023
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2. Xuebijing injection inhibited neutrophil extracellular traps to reverse lung injury in sepsis mice via reducing Gasdermin D

Author

Shang, Ting, primary, Zhang, Zhi-Sen, additional, Wang, Xin-Tong, additional, Chang, Jing, additional, Zhou, Meng-En, additional, Lyu, Ming, additional, He, Shuang, additional, Yang, Jian, additional, Chang, Yan-Xu, additional, Wang, Yuefei, additional, Li, Ming-Chun, additional, Gao, Xiumei, additional, Zhu, Yan, additional, and Feng, Yuxin, additional

Published
2022
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3. Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model

Author

Wang, Yule, primary, He, Shuang, additional, Liu, Xinyan, additional, Li, Zhixiong, additional, Zhu, Lin, additional, Xiao, Guangxu, additional, Du, Xiaoli, additional, Du, Hongxia, additional, Zhang, Wen, additional, Zhang, Yiqian, additional, Orgah, John, additional, Feng, Yuxin, additional, Zhang, Boli, additional, and Zhu, Yan, additional

Published
2021
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4. Paeoniflorin and Hydroxysafflor Yellow A in Xuebijing Injection Attenuate Sepsis-Induced Cardiac Dysfunction and Inhibit Proinflammatory Cytokine Production

Author

Wang, Xin-Tong, primary, Peng, Zhen, additional, An, Ying-Ying, additional, Shang, Ting, additional, Xiao, Guangxu, additional, He, Shuang, additional, Chen, Xi, additional, Zhang, Han, additional, Wang, Yuefei, additional, Wang, Tao, additional, Zhang, Jun-Hua, additional, Gao, Xiumei, additional, Zhu, Yan, additional, and Feng, Yuxin, additional

Published
2021
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9. Paeoniflorin Resists H2O2-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway.

Author

Yuan, Jinping, Lu, Yansong, Wang, Hexiao, Feng, Yuxin, Jiang, Shibin, Gao, Xing-Hua, Qi, RuiQun, Wu, Yan, and Chen, Hong-Duo

Subjects
OXIDATIVE stress, MELANOCYTES, SUPEROXIDE dismutase, HYDROGEN peroxide, REACTIVE oxygen species
Abstract

Paeoniflorin (PF) possesses multiple biological functions including anti-oxidization. PF is the major bioactive ingredient of total glycosides of paeony (TGP), which could promote re-pigmentation of vitiligo. The study was sought to investigate the effects and potential signaling pathways of PF on hydrogen peroxide (H2O2)-induced oxidative stress in melanocytes. The results showed that pretreatment with 50 µM PF significantly inhibited cell apoptosis, enhanced cell viability, and suppressed reactive oxygen species (ROS) accumulation by enhancing the productions of superoxide dismutase (SOD) and antioxidant enzymes catalase (CAT). Furthermore, PF activated c-Jun amino terminal kinase (JNK) and the nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway to counteract H2O2-induced oxidative damage in PIG1 and PIG3V. Taken together, our study firstly demonstrates that PF resists H2O2-induced oxidative stress in melanocytes probably by activating JNK/Nrf2/HO-1 signaling, suggesting a potential therapeutic application of PF on vitiligo. [ABSTRACT FROM AUTHOR]

Published
2020
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11. Paeoniflorin Resists H 2 O 2 -Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway.

Author

Yuan J, Lu Y, Wang H, Feng Y, Jiang S, Gao XH, Qi R, Wu Y, and Chen HD

Abstract

Paeoniflorin (PF) possesses multiple biological functions including anti-oxidization. PF is the major bioactive ingredient of total glycosides of paeony (TGP), which could promote re-pigmentation of vitiligo. The study was sought to investigate the effects and potential signaling pathways of PF on hydrogen peroxide (H 2 O 2 )-induced oxidative stress in melanocytes. The results showed that pretreatment with 50 µM PF significantly inhibited cell apoptosis, enhanced cell viability, and suppressed reactive oxygen species (ROS) accumulation by enhancing the productions of superoxide dismutase (SOD) and antioxidant enzymes catalase (CAT). Furthermore, PF activated c-Jun amino terminal kinase ( JNK ) and the nuclear factor E2-related factor 2 ( Nrf2 )/heme oxygenase-1 ( HO-1 ) pathway to counteract H 2 O 2 -induced oxidative damage in PIG1 and PIG3V. Taken together, our study firstly demonstrates that PF resists H 2 O 2 -induced oxidative stress in melanocytes probably by activating JNK/Nrf2/HO-1 signaling, suggesting a potential therapeutic application of PF on vitiligo., (Copyright © 2020 Yuan, Lu, Wang, Feng, Jiang, Gao, Qi, Wu and Chen.)

Published
2020
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