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Your search keyword '"Abdel-Daim, Mohamed M."' showing total 12 results
Start Over Author "Abdel-Daim, Mohamed M." Journal frontiers in pharmacology
12 results on '"Abdel-Daim, Mohamed M."'

1. Formulation of ciprofloxacin-loaded oral self-emulsifying drug delivery system to improve the pharmacokinetics and antibacterial activity

Author

Asghar, Asghar Ali, primary, Akhlaq, Muhammad, additional, Jalil, Aamir, additional, Azad, Abul Kalam, additional, Asghar, Junaid, additional, Adeel, Muhammad, additional, Albadrani, Ghadeer M., additional, Al-Doaiss, Amin A., additional, Kamel, Mohamed, additional, Altyar, Ahmed E., additional, and Abdel-Daim, Mohamed M., additional

Published
2022
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2. Dupilumab efficacy and safety in patients with moderate to severe asthma: A systematic review and meta-analysis

Author

Zaazouee, Mohamed Sayed, primary, Alwarraqi, Asmaa Gomaa, additional, Mohammed, Yasmine Adel, additional, Badheeb, Mohamed A., additional, Farhat, Abdullah Mohamed, additional, Eleyan, Mohammed, additional, Morad, Afnan, additional, Zeid, Marwa Abdel-Aziz, additional, Mohamed, Aya Shaban, additional, AbuEl-Enien, Hazem, additional, Abdelalim, Ahmed, additional, Elsnhory, Ahmed Bostamy, additional, Hrizat, Yasmin S. M., additional, Altahir, Nagat Taha, additional, Atef, Doaa, additional, Elshanbary, Alaa Ahmed, additional, Alsharif, Khalaf F., additional, Alzahrani, Khalid J., additional, Algahtani, Mohammad, additional, Theyab, Abdulrahman, additional, Hawsawi, Yousef M., additional, Aldarmahi, Ahmed A., additional, and Abdel-Daim, Mohamed M., additional

Published
2022
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3. Theoretical design for covering Engeletin with functionalized nanostructure-lipid carriers as neuroprotective agents against Huntington's disease via the nasal-brain route.

Author

Smriti, Singla, Madhav, Gupta, Saurabh, Porwal, Omji, Binjawhar, Dalal Nasser, Sayed, Amany A., Mittal, Pooja, El-Demerdash, Fatma M., Algahtani, Mohammad, Singh, Sachin Kumar, Dua, Kamal, Gupta, Gaurav, Bawa, Puneet, Altyar, Ahmed E., and Abdel-Daim, Mohamed M.

Subjects
HUNTINGTIN protein, HUNTINGTON disease, NEUROPROTECTIVE agents, LITERATURE reviews, MUTANT proteins, BLOOD-brain barrier
Abstract

Objective: To propose a theoretical formulation of engeletin-nanostructured lipid nanocarriers for improved delivery and increased bioavailability in treating Huntington's disease (HD). Methods: We conducted a literature review of the pathophysiology of HD and the limitations of currently available medications. We also reviewed the potential therapeutic benefits of engeletin, a flavanol glycoside, in treating HD through the Keap1/nrf2 pathway. We then proposed a theoretical formulation of engeletinnanostructured lipid nanocarriers for improved delivery across the blood-brain barrier (BBB) and increased bioavailability. Results: HD is an autosomal dominant neurological illness caused by a repetition of the cytosine-adenine-guanine trinucleotide, producing a mutant protein called Huntingtin, which degenerates the brain's motor and cognitive functions. Excitotoxicity, mitochondrial dysfunction, oxidative stress, elevated concentration of ROS and RNS, neuroinflammation, and protein aggregation significantly impact HD development. Current therapeutic medications can postpone HD symptoms but have long-term adverse effects when used regularly. Herbal medications such as engeletin have drawn attention due to their minimal side effects. Engeletin has been shown to reduce mitochondrial dysfunction and suppress inflammation through the Keap1/NRF2 pathway. However, its limited solubility and permeability hinder it from reaching the target site. A theoretical formulation of engeletin-nanostructured lipid nanocarriers may allow for free transit over the BBB due to offering a similar composition to the natural lipids present in the body a lipid solubility and increase bioavailability, potentially leading to a cure or prevention of HD. Conclusion: The theoretical formulation of engeletin-nanostructured lipid nanocarriers has the potential to improve delivery and increase the bioavailability of engeletin in the treatment of HD, which may lead to a cure or prevention of this fatal illness. [ABSTRACT FROM AUTHOR]

Published
2023
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4. Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma

Author

Uddin, Md. Sahab, primary, Kabir, Md. Tanvir, additional, Mamun, Abdullah Al, additional, Sarwar, Md. Shahid, additional, Nasrin, Fatema, additional, Emran, Talha Bin, additional, Alanazi, Ibtesam S., additional, Rauf, Abdur, additional, Albadrani, Ghadeer M., additional, Sayed, Amany A., additional, Mousa, Shaker A., additional, and Abdel-Daim, Mohamed M., additional

Published
2021
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6. Resveratrol and Neuroprotection: Impact and Its Therapeutic Potential in Alzheimer's Disease

Author

Rahman, Md. Habibur, primary, Akter, Rokeya, additional, Bhattacharya, Tanima, additional, Abdel-Daim, Mohamed M., additional, Alkahtani, Saad, additional, Arafah, Mohammed W., additional, Al-Johani, Norah S., additional, Alhoshani, Norah M., additional, Alkeraishan, Nora, additional, Alhenaky, Alhanof, additional, Abd‐Elkader, Omar H., additional, El-Seedi, Hesham R, additional, Kaushik, Deepak, additional, and Mittal, Vineet, additional

Published
2020
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7. COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

Author

Hossain, Md. Farhad, primary, Hasana, Sharifa, additional, Mamun, Abdullah Al, additional, Uddin, Md. Sahab, additional, Wahed, Mir Imam Ibne, additional, Sarker, Sabarni, additional, Behl, Tapan, additional, Ullah, Irfan, additional, Begum, Yesmin, additional, Bulbul, Israt Jahan, additional, Amran, Md. Shah, additional, Rahman, Md. Habibur, additional, Bin-Jumah, May N., additional, Alkahtani, Saad, additional, Mousa, Shaker A., additional, Aleya, Lotfi, additional, and Abdel-Daim, Mohamed M., additional

Published
2020
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8. Available Compounds With Therapeutic Potential Against COVID-19: Antimicrobial Therapies, Supportive Care, and Probable Vaccines

Author

Kumar, Rajnish, primary, Srivastava, Janmejai Kumar, additional, Singh, Rachana, additional, Siddiqui, Mohammed Haris, additional, Mansouri, Rasha A., additional, Abdulhakim, Jawaher A., additional, Bin-Jumah, May N., additional, Alkahtani, Saad, additional, Abdel-Daim, Mohamed M., additional, and Uddin, Md. Sahab, additional

Published
2020
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10. Emerging Promise of Cannabinoids for the Management of Pain and Associated Neuropathological Alterations in Alzheimer’s Disease

Author

Uddin, Md. Sahab, primary, Mamun, Abdullah Al, additional, Sumsuzzman, Dewan Md., additional, Ashraf, Ghulam Md, additional, Perveen, Asma, additional, Bungau, Simona G., additional, Mousa, Shaker A., additional, El-Seedi, Hesham R., additional, Bin-Jumah, May N., additional, and Abdel-Daim, Mohamed M., additional

Published
2020
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11. Mesenchymal Stem Cell Therapy for Doxorubicin-Induced Cardiomyopathy: Potential Mechanisms, Governing Factors, and Implications of the Heart Stem Cell Debate

Author

Abushouk, Abdelrahman Ibrahim, primary, Salem, Amr Muhammad Abdo, additional, Saad, Anas, additional, Afifi, Ahmed M., additional, Afify, Abdelrahman Yousry, additional, Afify, Hesham, additional, Salem, Hazem S.E., additional, Ghanem, Esraa, additional, and Abdel-Daim, Mohamed M., additional

Published
2019
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