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Hypertension is one of the most important factors responsible for cardiovascular ailments worldwide. It has been observed that herbal products and alternative herbal therapies played a significant role in decreasing hypertension. The aim of the current study is to provide significant ethnopharmacological information, both qualitative and quantitative on medicinal plants related to hypertension from Northern Pakistan. The documented data were quantitatively analyzed for the first time in this area. A total of 250 participants were interviewed through semi-structured discussions and questionnaires. Quantitative indices including FC (Frequency citation), FIV (Family importance value), RFC (Relative frequency of citation) and DCI (Disease Consensus index) were calculated. A total of 192 plant species, belonging to 77 families were reported to be used in treatment of hypertension in Northern Pakistan. The most dominant life form reported was herbs (54%), with decoction (72 reports) and leaves (55.1%) were commonly utilized plant part. Highest FIV was recorded in Lamiaceae (327 FIV). RFC ranged from 0.08 to 1.08% while DCI varied from 0.233 to 0.000. In this study original data was compared with thirty one previous national and international published papers from neighboring region to compare the medicinal uses and obtain some novel plant species. About 42% of the medicinal plant species were reported for the first time in treatment of hypertension in comparison to these 31 published papers. Different phytochemical activities of antihypertensive plants were also reported from literature. This research work documents the traditional knowledge of medicinal plants usage and provides baseline in designing clinical trials and pharmacological analysis for treatment of hypertension. [ABSTRACT FROM AUTHOR]

Food and nutritional security are the major concerns in many countries of the world and may have potential to contribute to sustainable food systems under climate change. To address the food and nutritional insecurity, it has become extremely important to diversify the present-day agricultural system as well as to search for alternative food and feed ingredients. Some wild root and tuber crops occupy a remarkable position toward food security of the developing world due to their high calorific value and superior carbohydrate content. Yam (Dioscorea spp.) provides food and medicines to millions of people in the world especially in the tropics and sub tropics. It is recognized as the fourth most important tuber crop after potatoes, cassava, and sweet potatoes. It contributes about 10% of the total root and tubers production around the world. Yams also considered as famine food and plays a prime role in the food habit of small and marginal rural families and forest-dwelling communities during the food scarcity periods. These species are unique for their food, medicinal and economic values but their wider utilization is limited due to the presence of anti-nutritional compositions. This paper describes the ethnobotany of yam species in relation to their nutritional, anti-nutritional and pharmacological properties and highlights the potentiality for food and nutritional security for combating the "hidden hunger" caused by micronutrient deficiencies. [ABSTRACT FROM AUTHOR]

Introduction: Mental disorders are among the leading causes of ill-health and disability worldwide. Despite the disease burden they cause, including significant direct and indirect impacts on individual's health and major social and economic consequences in all countries of the world, it is still one of the most neglected areas of public health. In such a context, the medicinal plants traditionally used to pale these pathologies are presented as a promising tool for future drug development for the management of mental health disorders. The aim of the present study is to analyze the information about plant species used to treat mental disorders in the Catalan linguistic area (CLA) and compare these traditional uses with pharmacological literature in order to evaluate the most quoted taxa and their uses and to provide a basis for further research. Methods: Data have been recovered from the "Etnobotànica dels Països Catalans" webpage (https://etnobotanica.iec.cat/) and the meta-analytic work carried out in the present study covers 27 prospections performed in different territories between 1990 and 2019. Descriptive statistics and quantitative ethnobotany were carried out and some ethnobotanical indices were calculated. Results and Discussion: The number of use reports analysed to treat mental disorders in CLA is 2,544 spread over 183 taxa belonging to 64 families, being the most cited the Malvaceae (29.36% of use reports), Lamiaceae (16.71%), Caprifoliaceae (7.94%), Rutaceae (7.47%) and Papaveraceae (6.01%). The most used taxa to treat or alleviate the mental disorders have been Tilia platyphyllos Scop. (24.53%), Valeriana officinalis L. (7.47%), Salvia officinalis L. (5.07%), Sambucus nigra L. (4.28%), and Ruta chalepensis L. (3.89%). The flowers or inflorescences (47.68%), followed by aerial part (23.49%), have been the most used plant parts, and tisane the most commonly used pharmaceutical form (78. 03%). The most reported use is as sedative with 40.92%, followed by anticephalalgic (21. 19%) and tranquilizer (20.01%). The informant consensus factor (FIC) was 0.93, and 3.72% was the ethnobotanicity index (EI) value. The information is coincidental with at least one of the comprehensive pharmacological literature sources checked for 73.68% of ethnobotanical uses. [ABSTRACT FROM AUTHOR]

Hypertension is one of the most important factors responsible for cardiovascular ailments worldwide. It has been observed that herbal products and alternative herbal therapies played a significant role in decreasing hypertension. The aim of the current study is to provide significant ethnopharmacological information, both qualitative and quantitative on medicinal plants related to hypertension from Northern Pakistan. The documented data were quantitatively analyzed for the first time in this area. A total of 250 participants were interviewed through semi-structured discussions and questionnaires. Quantitative indices including FC (Frequency citation), FIV (Family importance value), RFC (Relative frequency of citation) and DCI (Disease Consensus index) were calculated. A total of 192 plant species, belonging to 77 families were reported to be used in treatment of hypertension in Northern Pakistan. The most dominant life form reported was herbs (54%), with decoction (72 reports) and leaves (55.1%) were commonly utilized plant part. Highest FIV was recorded in Lamiaceae (327 FIV). RFC ranged from 0.08 to 1.08% while DCI varied from 0.233 to 0.000. In this study original data was compared with thirty one previous national and international published papers from neighboring region to compare the medicinal uses and obtain some novel plant species. About 42% of the medicinal plant species were reported for the first time in treatment of hypertension in comparison to these 31 published papers. Different phytochemical activities of antihypertensive plants were also reported from literature. This research work documents the traditional knowledge of medicinal plants usage and provides baseline in designing clinical trials and pharmacological analysis for treatment of hypertension.

Background: The research into bioactive natural products of medicinal plants has a long tradition, but ethnopharmacology as a well-defined field of research has a relatively short history, only dating back 50 years. Aims: With the fast development of this field and its global importance especially in the fast developing economies of Asia it is timely to assess the most influential articles (as measured by citations) and to identify important drivers and research trends in this field. Methods: Scopus was searched to identify relevant articles which were assessed by all three authors. The 100 most cited articles were identified and analyzed. Bibliometric software (VOSviewer) was utilized to supplement the analysis and to generate a term map that visualized the citation patterns of the 100 articles containing different terms. Results: Forty-four of the 100 articles are reviews. On average, each of the 100 articles had 632 citations and since publication was cited 43 times annually. The four core journals were Journal of Ethnopharmacology (n = 17), Food Chemistry (n = 7), Life Sciences (n = 5), and Journal of Agricultural and Food Chemistry (n = 4). Anti-oxidant effects appeared to be a recurring and highly cited topic, whereas the links into drug discovery and neuropharmacology seemed to be less strong. Numerousmedicinal plants and functional foods were the foci of research, and the foci shifted when comparing pre-2000 and post-2000 publications (with the later involving a broader spectrum of plants and foods and a wider range of biological effects). Contributions largely came from Asia, and also from the Americas, Africa, and Oceania, besides Europe. Conclusion: We have identified and analyzed the 100 most-cited articles in ethnopharmacology. Within 50 years the field has gained a profile and while conventionally often linked to "traditional knowledge," drug discovery and some areas of pharmacology, this analysis highlights its emerging importance in the context of disease prevention (food science), but also the development of research driven by the needs and interests of the fast developing economies most notably of Asia. [ABSTRACT FROM AUTHOR]

Cannabis sativa, also known as "hemp" or "weed," is a versatile plant with various uses in medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available literature on the ecology, chemical composition, phytochemistry, pharmacology, traditional uses, industrial uses, and toxicology of Cannabis sativa. So far, 566 chemical compounds have been isolated from Cannabis, including 125 cannabinoids and 198 non-cannabinoids. The psychoactive and physiologically active part of the plant is a cannabinoid, mostly found in the flowers, but also present in smaller amounts in the leaves, stems, and seeds. Of all phytochemicals, terpenes form the largest composition in the plant. Pharmacological evidence reveals that the plants contain cannabinoids which exhibit potential as antioxidants, antibacterial agents, anticancer agents, and anti-inflammatory agents. Furthermore, the compounds in the plants have reported applications in the food and cosmetic industries. Significantly, Cannabis cultivation has a minimal negative impact on the environment in terms of cultivation. Most of the studies focused on the chemical make-up, phytochemistry, and pharmacological effects, but not much is known about the toxic effects. Overall, the Cannabis plant has enormous potential for biological and industrial uses, as well as traditional and other medicinal uses. However, further research is necessary to fully understand and explore the uses and beneficial properties of Cannabis sativa. [ABSTRACT FROM AUTHOR]

Medicinal plants are the primary source of traditional healthcare systems in many rural areas mostly in developing countries. This study aimed to document and analyze the diversity, distribution, and sustainability of the traditional medicinal plants used by the Gurung people of the Sikles region in western Nepal. Ethnobotanical data were collected through focus group discussions and individual interviews, and analyzed using descriptive and inferential statistics. Prior informed consent was obtained before each interview. Quantitative ethnobotanical indices such as informant consensus factor, relative frequency of citation, and use values were also calculated. A possible association among these indices was tested using correlation analysis. A total of 115 wild medicinal plant species belonging to 106 genera and 71 families were documented. Asteraceae and Rosaceae were the dominant families whereas herbs were the most dominant life form. Roots were the most used plant part, paste was the most common method of preparation, and most of the medical formulations were taken orally. The highest number of medicinal plants were used to treat stomach disorders. The average informant consensus value of 0.79 indicates a high consensus among respondents in selecting medicinal plants. Lindera neesiana, Neopicrorhiza scrophulariiflora, Paris polyphylla, and Bergenia ciliata were found to be high-ranking medicinal plants based on the relative frequency of citation and use value. The genders did not affect medicinal plants' knowledge but age had a significant correlation. Most of the informants agreed that medicinal plants are under pressure due to overharvesting and a lack of proper forest management practices. The number of medicinal plants reported from the study area indicates that the Gurung people possess rich traditional knowledge, and the vegetation of the Sikles region constitutes rich diversity of medicinal plants. [ABSTRACT FROM AUTHOR]

Tetraclinis articulata (Vahl) Masters, commonly known as Sandarac tree and Araâr, is the only species representing the genus Tetraclinis Masters. The plant has been extensively used for medicinal, artistic, and ritual purposes since its first recorded use in 1800 B.C. Recently, a full range of ethnobotanical investigations has been undertaken to document the plant's empirical knowledge. They reported the use of different parts, such as leaves, stems, cones, bark, and roots, as part of folk healing practices to manage diabetes mellitus, hypertension, fever, stomach disorders, and diarrhea, among others. The phytochemical studies have identified at least 130 compounds from leaves, cones, resin, bark, and woods. These chemical constituents are categorized into phenolic acids, flavonoids and their derivatives, volatile compounds, phytosterols, and fatty acids, among others. Furthermore, they have strongly been correlated with the promising antimicrobial, antioxidant, neuroprotective, antiurolithiatic, anti-inflammatory, antidiabetic, and cytotoxic properties of the plant. Toxicological studies argued that the plant is quite safe and devoid of eventual toxicity; however, in-depth investigations are required to validate the safety of the plant. The remarkable antimicrobial and antioxidant potencies of various extracts from the plant against a wide range of foodborne pathogens support their possible use to increase the shelf life of foodstuffs in the food industry. Likewise, various plant-based extracts have been proven to exert substantial biocidal properties, making them potential alternatives to synthetic pesticides in agriculture. The present review provides an up-todate comprehensive insight about the ethnobotanical uses of T. articulata, along with its phytochemistry and biological activities to furnish directions for further studies. We also discussed the biocidal potency of the plant and highlighted its usage to extend the shelf life of perishable foods. [ABSTRACT FROM AUTHOR]

Globally, the search for safe and potent natural-based treatment for depression is receiving renewed interest given the numerous side-effects associated with many existing drugs. In South Africa, the use of plants to manage depression and related symptoms is fairly documented among different ethnic groups. In the current study, we reviewed existing ethnobotanical, ethnopharmacological and phytochemical studies on South African medicinal plants used to manage depression. Electronic databases were accessed for scientific literature that meets the inclusion criteria. Plants with ethnobotanical evidence were subjected to a further pharmacological review to establish the extent (if any) of their effectiveness as antidepressants. Critical assessment resulted in 20 eligible ethnobotanical records, which generated an inventory of 186 plants from 63 plant families. Due to the cultural differences observed in the definition of depression, or lack of definition in some cultures, most plants are reported to treat a wide range of atypical symptoms related to depression. Boophone disticha , Leonotis leonurus and Mentha longifolia were identified as the three most popular plants, with over eight mentions each from the ethnobotanical records. The dominant families were Asteraceae (24), Fabaceae (16), Amaryllidaceae (10), and Apocynaceae (10) which accounted for about 32% of the 186 plants. Only 27 (≈14.5%) of the plants have been screened for antidepressant activity using in vitro and in vivo models. Agapanthus campanulatus , Boophone disticha , Hypericum perforatum , Mondia whitei and Xysmalobium undulatum , represent the most studied plants. Phytochemical investigation on nine out of the 27 plants revealed 24 compounds with antidepressant-like effects. Some of these included buphanidrine and buphanamine which were isolated from the leaves of Boophone disticha , Δ9-tetrahydrocannabinol, cannabidiol and cannabichromene obtained from the buds of Cannabis sativa and carnosic acid, rosmarinic acid and salvigenin from Rosmarinus officinalis , A significant portion (≈85%) of 186 plants with ethnobotanical records still require pharmacological studies to assess their potential antidepressant-like effects. This review remains a valuable reference material that may guide future ethnobotanical surveys to ensure their robustness and validity as well as database to identify promising plants to screen for pharmacology efficacy. [ABSTRACT FROM AUTHOR]

The health benefits and toxicity of plant products are largely dependent on their secondary metabolite contents. These compounds are biosynthesized by plants as protection mechanisms against environmental factors and infectious agents. This review discusses the traditional uses, phytochemical constituents and health benefits of plant species in genus Zanthoxylum with a focus on cancer, microbial and parasitic infections, and sickle cell disease as reported in articles published from 1970 to 2021 in peer-reviewed journals and indexed in major scientific databases. Generally, Z. species are widely distributed in Asia, America and Africa, where they are used as food and for disease treatment. Several compounds belonging to alkaloids, flavonoids, terpenoids, and lignans, among others have been isolated from Z. species. This review discusses the biological activities reported for the plant species and their phytochemicals, including anticancer, antibacterial, antifungal, antiviral, anti-trypanosomal, antimalarial and anti-sickling properties. The safety profiles and suggestions for conservation of the Z. species were also discussed. Taken together, this review demonstrates that Z. species are rich in a wide range of bioactive phytochemicals with multiple health benefits, but more research is needed towards their practical application in the development of functional foods, nutraceuticals and lead compounds for new drugs. [ABSTRACT FROM AUTHOR]

Ethnobotanical knowledge is indispensable for the conservation of global biological integrity, and could provide irreplaceable clues for bioprospecting aiming at new food crops and medicines. This biocultural diversity requires a comprehensive documentation of such intellectual knowledge at local levels. However, without systematically capturing the data, those regional records are fragmented and can hardly be used. In this study, we develop a framework to assemble the cross-cultural ethnobotanical knowledge at a genus level, including capturing the species' diversity and their cultural importance, integrating their traditional uses, and revealing the intercultural relationship of ethnobotanical data quantitatively. Using such a cross-cultural ethnobotanical assembly, the medicinal and culinary values of the genus Lycium are evaluated. Simultaneously, the analysis highlights the problems and options for a systematic cross-cultural ethnobotanical knowledge assembly. The framework used here could generate baseline data relevant for conservation and sustainable use of plant diversity as well as for bioprospecting within targeting taxa. [ABSTRACT FROM AUTHOR]

Food and nutritional security are the major concerns in many countries of the world and may have potential to contribute to sustainable food systems under climate change. To address the food and nutritional insecurity, it has become extremely important to diversify the present-day agricultural system as well as to search for alternative food and feed ingredients. Some wild root and tuber crops occupy a remarkable position toward food security of the developing world due to their high calorific value and superior carbohydrate content. Yam (Dioscorea spp.) provides food and medicines to millions of people in the world especially in the tropics and sub tropics. It is recognized as the fourth most important tuber crop after potatoes, cassava, and sweet potatoes. It contributes about 10% of the total root and tubers production around the world. Yams also considered as famine food and plays a prime role in the food habit of small and marginal rural families and forest-dwelling communities during the food scarcity periods. These species are unique for their food, medicinal and economic values but their wider utilization is limited due to the presence of anti-nutritional compositions. This paper describes the ethnobotany of yam species in relation to their nutritional, anti-nutritional and pharmacological properties and highlights the potentiality for food and nutritional security for combating the “hidden hunger” caused by micronutrient deficiencies.

Balkan Peninsula is one of the most important biodiversity centers in Europe. Despite that, the usage of plant species in the traditional medicine of some Balkan regions remained largely unexplored in the past. This study aimed to collect and document data on the traditional use of medicinal plants in Pčinja district in South-Eastern Serbia, which is among the least developed regions in Serbia. Also, comparison with data collected by Dr. Jovan Tucakov, in a book called Herbal therapy was conducted. The survey was carried out using semi-structured interviews and 113 informants were interviewed. Quantitative ethnobotany factors were calculated, allowing us discussing the results. The informants reported data on 86 medicinal plants belonging to 43 families in Pčinja district. Lamiaceae, Asteraceae , and Rosaceae were the dominant locally used families. The species with the highest number of use reports were Mentha piperita , Matricaria chamomilla , and Hypericum perforatum. Gastrointestinal ailments, respiratory problems and skin diseases were the most frequently reported indications. Usually, the administration was primarily oral followed by topical applications. Leaves were dominantly exploited plant parts and the most frequent preparation form was infusion. Medicinal plants in Pčinja district are mainly used as a mode of primary health care for treating minor health issues. After comparing our results with the ones collected half a century ago by Dr. Jovan Tucakov we can conclude that plant species mentioned in our investigation previously had a much wider spectrum of application. [ABSTRACT FROM AUTHOR]

Herbal tea, a beverage prepared from a variety of plant materials excluding the leaves of the tea plant Camellia sinensis (L.) Kuntze of the family Theaceae, for a long time, has been consumed by most Chinese people for preventive and/or therapeutic health care. Usually, it is brewed or prepared as a decoction of local plants in water. The qīng-căo-chá tea, a commercial herbal tea, is the most common among many differently formulated herbal teas in Taiwan. For hundreds of years, qīng-căo-chá tea has played an important role in the prevention and treatment of diseases associated with the environmental conditions in Taiwan. However, research studies in this field have been insufficient. The raw material formulas of qīng-căo-chá tea have always been passed down from "masters" to "apprentices." Hence, there is no systematic collation or record, and, therefore, there is a need to assess and confirm the composition, safety, and effectiveness of the raw materials. This study aimed to document the uses of Taiwan's qīng-căo-chá tea through a semi-structured interview survey and investigate the background of traditional practitioners, tea compositions, and plant origins and uses. This will improve our understanding of the knowledge inherited by the practitioners and the theoretical basis of the medicinal uses of these teas. In our field investigation, we visited 86 shops and assessed 71 raw ingredients of qīng-căo-chá tea. A semi-structured questionnaire was used to conduct the interviews. During the interviews, in addition to written records, audio and video recordings were made, and photographs were taken with the permission of the interviewees. The qīng-căo-chá raw materials have long been used as herbal teas, although more research should clarify their efficacy and safety. Traditional sellers of qīng-căo-chá tea were mainly males, and most shops have been in operation for more than 71 years. Some of the raw materials were derived from multiple sources, including different plants, and were often mixed without any safety concerns. To our knowledge, this is the first systematic ethnobotanical study on qīng-căo-chá tea that assesses and confirms its herbal ingredients. Our study represents a reference for herbal teas in Taiwan that can be used by the public and regulatory agencies. [ABSTRACT FROM AUTHOR]

The Solanaceae is an important plant family that has been playing an essential role in traditional medicine and human nutrition. Members of the Solanaceae are rich in bioactive metabolites and have been used by different tribes around the world for ages. Antimicrobial peptides (AMPs) from plants have drawn great interest in recent years and raised new hope for developing new antimicrobial agents for meeting the challenges of antibiotic resistance. This review aims to summarize the reported AMPs from plants of the Solanaceae with possible molecular mechanisms of action as well as to correlate their traditional uses with reported antimicrobial actions of the peptides. A systematic literature study was conducted using different databases until August 2019 based on the inclusion and exclusion criteria. According to literature, a variety of AMPs including defensins, protease inhibitor, lectins, thionin-like peptides, vicilin-like peptides, and snaking were isolated from plants of the Solanaceae and were involved in their defense mechanism. These peptides exhibited significant antibacterial, antifungal and antiviral activity against organisms for both plant and human host. Brugmansia, Capsicum , Datura , Nicotiana, Salpichora, Solanum , Petunia , and Withania are the most commonly studied genera for AMPs. Among these genera, Capsicum and the Solanum ranked top according to the total number of studies (35%–38% studies) for different AMPs. The mechanisms of action of the reported AMPs from Solanaceae was not any new rather similar to other reported AMPs including alteration of membrane potential and permeability, membrane pore formation, and cell aggregation. Whereas, induction of cell membrane permiabilization, inhibition of germination and alteration of hyphal growth were reported as mechanisms of antifungal activity. Plants of the Solanaceae have been used traditionally as antimicrobial, insecticidal, and antiinfectious agents, and as poisons. The reported AMPs from the Solanaceae are the products of chemical shields to protect plants from microorganisms and pests which unfold an obvious link with their traditional medicinal use. In summary, it is evident that AMPs from this family possess considerable antimicrobial activity against a wide range of bacterial and fungal pathogens and can be regarded as a potential source for lead molecules to develop new antimicrobial agents. [ABSTRACT FROM AUTHOR]

Greek islands of the North Aegean Region are a group of nine inhabited islands (Lemnos, Agios Efstratios, Lesvos, Chios, Psara, Oinousses, Samos, Ikaria, and Fourni) located in the northern part of the Aegean Sea, close to Asia Minor. Each island of this region can be considered autonomous in terms of culture and biodiversity. With this work we try to evaluate the status of the traditional uses of medicinal plants in this region. Endemic and endangered species such as Sideritis sipylea Boiss., Origanum sipyleum L., Thymus sipyleus Boiss., Pistacia lentiscus L., Verbascum ikaricum Murb., are still used by locals to treat different ailments. Moreover, the use of some species for the treatment of specific diseases has been reported for the first time. We report about 109 wild plants of medicinal importance, from 52 families, listing their uses for therapeutic purposes and galenic preparations provided by local medical doctors and pharmacists. The information we include was derived from literature sources and additionally collected through semi-structured interviews conducted on 200 informants (100 men and 100 women). Additionally, informant consensus factor (FIC) and UV value were calculated for the medicinal plants in the current study in relation with the diseases treated. This research confirms the importance of the medicinal plants and the diffusion of their use in traditional medicine within this region. This ethnopharmacological survey is a fundamental step for the preservation of the local knowledge both for further scientific research and for the protection of endangered and endemic medicinal plants. [ABSTRACT FROM AUTHOR]

A number of wild crops remain unexplored in this world and among them some have excellent medicinal and nutritional properties. India is a harbor of biodiversity in general and phytodiversity in particular. The plant diversity is distributed from the Western Ghats to Eastern Ghats, along with the North-Eastern region and from the Greater Himalayas to the plain of Ganga. Among these distributed floral regions of the country, the Eastern Ghats are important due to their rich floral diversity. The forests of Odisha form a major part of Eastern Ghats in general and the Similipal Biosphere Reserve (SBR) in particular. The SBR is inhabited by many local communities. The food and medicinal habits of these communities are not fully explored even today. They are dependent on the forests of SBR for their food and medicine. Among their collections from forests, root and tuberous plants play a significant role. The local communities of SBR use about 89 types of tuberous plants for various purposes. Dioscorea is one such tuber, having maximum use among the local of SBR. However, less documentation and no specific reports are available on the food and medicinal values of the species available in this part of the World. Dioscorea species, popularly known as Yam worldwide and as Ban Aalu in Odisha, India, is a prime staplemedicinal-food substitute for themajority of rural and local people of the state of India. Of the 13 Dioscorea species available in SBR, 10 species are known to be bitter in taste and unpalatable when taken raw. Since less documentation is available on the Dioscorea species of SBR and their traditional uses, the present study was focused on the ethnobotany, nutritional and pharmacological values of these species along its nutraceutical importance. [ABSTRACT FROM AUTHOR]

The Adriatic islands in Croatia, usually divided into two archipelagos – the Kvarner and Dalmatian islands – is one of the largest groups of islands in Europe. Over 40 islands are still inhabited. Unfortunately the traditional use of medicinal plants was never properly documented there. Our data comes from 343 interviews carried out in 36 islands, including the 15 largest islands of the archipelago. The medicinal plants are mainly used to make herbal infusions or decoctions, occasionally medicinal liqueurs, syrups, compresses, or juices squeezed out of raw plants. We recorded the use of 146 taxa, among them 131 with at least one medicinal purpose and 15 only for tea. The frequency curve of use is relatively steep – several plants are used very frequently and most are reported only by one or two informants, which can be explained both by the large geographical spread of the area, and even more so by the devolution of local knowledge and disappearance of gathering practices due to specialization in tourism, modernization and depopulation. Most of the gathered plants already occur in ancient and medieval herbals and are a part of the pan-Mediterranean pharmacopoeia. [ABSTRACT FROM AUTHOR]

Multipurpose herbal teas with numerous ingredients, in which flowers are the main component, are common in the traditional medicine and pharmacy of Greece and the Eastern Mediterranean countries. In this study, we combine ethnobotany and ethnopharmacology field work techniques and botany and pharmacognosy laboratory methods for the study of traditional herbal mixtures with flowers, we identify their botanical ingredients and record the local medicinal uses of these mixtures, in Greece, Lebanon, Syria, Iran and Turkey. These, and their industrial versions, are analyzed, using morphological and multivariate analysis techniques in order to determine marker species, relevant patterns of combination and local styles. The medicinal properties attributed to the different flowers are discussed in relation with their role in the mixtures. These blends are consumed for their relaxing, digestive, and anti-infective properties. These mixtures are not consumed as a treatment when one is sick but rather to avoid getting sick, as a preventive measure. The formulations can reach forty ingredients (sarantha in Greek, arbain in Arabic language of Palestine), usually entire or coarsely chopped in the more traditional formulations, leading to extreme variability of individual doses. We ask what biological signification this randomness can have. To give an answer requires new and more comprehensive pharmacological approaches. The flowers of Rosaceae, Asteraceae, Lamiaceae, Malvaceae and Fabaceae species characterize these mixtures in which other materials (roots, leaves, and fruits) and other species are present as well. Flowers of some species, particularly of Fabaceae, are exclusively used in mixtures, and their use in monospecific herbal teas is not yet recorded. We draw attention on the urgent need in exhaustively recording in Greece and the Near East, the formulation and use of traditional herbal mixtures and their numerous local variants. To consider these mixtures and the contribution of flowers (most mixtures receive the general name of tea of flowers) merits further extensive study. [ABSTRACT FROM AUTHOR]

The smoketree (Cotinus coggygria) is a historically known medicinal plant from Southeast Europe. Its ethnomedicinal use in skin and mucosal lesions is commonly accepted across countries. Other utilizations reported locally include fever reduction, cardiac diseases, hypertension, urinary diseases, cough, asthma, hemorrhoids, diabetes, numbness of arm, liver disease, and cancer. Departing from the smoketree's traditional uses, this review summarizes investigations on the phytochemistry and bioactivity of the plant. In vitro and in vivo experiments supporting wound-healing, anti-inflammatory, antibacterial, cytotoxic, antioxidative, hepatoprotective, and antidiabetic effects are presented. Metabolites from smoketree that are responsible for the main pharmacological effects of smoketree are pointed out. Furthermore, the review performs a comparison between C. coggygria and the lacquer tree (Toxicodendron vernicifluum). The latter is a comprehensively studied species used in Asian phytotherapy, with whom the European smoketree shares a consistent pool of secondary metabolites. The comparative approach aims to open new perspectives in the research of smoketree and anticipates an optimized use of C. coggygria in therapy. It also points out the relevance of a chemosystematic approach in the field of medicinal plants research. [ABSTRACT FROM AUTHOR]