1. MiR-222-3p in Platelets Serves as a Distinguishing Marker for Early Recognition of Kawasaki Disease
- Author
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Bo Wang, Li-nong Wang, Fang-fang Cheng, Hai-tao Lv, Ling Sun, Dong-kai Wei, Yu Pu, Jie Wu, Yuan-yuan Hou, Bin Wen, Xia-ping Xu, and Wen-hua Yan
- Subjects
Kawasaki disease ,other febrile illness ,miRNAs ,platelets ,miR-222-3p ,Pediatrics ,RJ1-570 - Abstract
Kawasaki disease (KD) is an acute vasculitis, which leads to 20% of sufferers developing coronary artery aneurysm in children if not appropriately treated. Therefore, the early diagnosis of KD is essential for alleviating the risk of developing heart disease. MicroRNAs (miRNAs) are a large class of small non-coding RNAs which post-transcriptionally regulate gene expression and have been shown to play critical roles in numerous biological processes and diseases. In this study, we used high-throughput miRNA sequencing and found dozens of miRNAs are highly expressed in platelets. By comparing the miRNA expression profile of platelets of acute KD patients and other febrile patients, miR-222-3p is validated to be significantly upregulated in platelets of acute KD patients. Furthermore, KEGG pathway analysis shows that targets of miR-222-3p are enriched in immune-related signaling pathways. Our study uncovers the potential of miR-222-3p in platelets as biomarker for early diagnosis of Kawasaki disease.
- Published
- 2019
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