1. Prognostic significance of CNSL at diagnosis of childhood B-cell acute lymphoblastic leukemia: A report from the South China Children’s Leukemia Group
- Author
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Lu-Hong Xu, Xu Geng, Ning Liao, Li-Hua Yang, Hui-Rong Mai, Wu-Qing Wan, Li-Bin Huang, Min-Cui Zheng, Chuan Tian, Hui-Qin Chen, Qi-Wen Chen, Xing-Jiang Long, Zi-Jun Zhen, Ri-Yang Liu, Qiao-Ru Li, Bei-Yan Wu, Li-Na Wang, Xian-Ling Kong, Guo-Hua Chen, Jian-Pei Fang, and Yang Li
- Subjects
acute lymphoblastic leukemia ,central nervous system leukemia ,childhood ,prognosis ,relapse ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
ObjectivesThe prognostic significance of acute lymphoblastic leukemia (ALL) patients with central nervous system leukemia (CNSL) at diagnosis is controversial. We aimed to determine the impact of CNSL at diagnosis on the clinical outcomes of childhood B-cell ALL in the South China Children’s Leukemia Group (SCCLG).MethodsA total of 1,872 childhood patients were recruited for the study between October 2016 and July 2021. The diagnosis of CNSL depends on primary cytological examination of cerebrospinal fluid, clinical manifestations, and imaging manifestations. Patients with CNSL at diagnosis received two additional courses of intrathecal triple injections during induction.ResultsThe frequency of CNLS at the diagnosis of B-cell ALL was 3.6%. Patients with CNSL at diagnosis had a significantly higher mean presenting leukocyte count (P = 0.002) and poorer treatment response (P
- Published
- 2022
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