1. Cell Plasticity-Related Phenotypes and Taxanes Resistance in Castration-Resistant Prostate Cancer
- Author
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Natalia Jiménez, Òscar Reig, Ruth Montalbo, Maria Milà-Guasch, Lluis Nadal-Dieste, Giancarlo Castellano, Juan José Lozano, Iván Victoria, Albert Font, Alejo Rodriguez-Vida, Joan Carles, Cristina Suárez, Montserrat Domènech, Núria Sala-González, Pedro Luis Fernández, Leonardo Rodríguez-Carunchio, Sherley Díaz, Aleix Prat, Mercedes Marín-Aguilera, and Begoña Mellado
- Subjects
cell plasticity ,EMT—epithelial-mesenchymal transition ,neuroendocrine ,castration-resistant prostate cancer ,docetaxel ,cabazitaxel ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The prostatic tumor cells plasticity is involved in resistance to hormone-therapy, allowing these cells to survive despite androgen receptor inhibition. However, its role in taxanes resistance has not been fully established. Gene expression of plasticity-related phenotypes such as epithelial-mesenchymal transition (EMT), stem cell-like and neuroendocrine (NE) phenotypes was studied in vitro, in silico, in circulating tumor cells (CTCs) (N=22) and in tumor samples (N=117) from taxanes-treated metastatic castration-resistant prostate cancer (mCRPC) patients. Docetaxel (D)-resistant cells presented a more pronounced EMT phenotype than cabazitaxel (CZ)-resistant cells. In silico analysis revealed ESRP1 down-regulation in taxane-exposed mCRPC samples. Cell plasticity-related changes occurred in CTCs after taxanes treatment. Tumor EMT phenotype was associated with lower PSA progression-free survival (PFS) to D (P
- Published
- 2020
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