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Your search keyword '"Cheng, Shu"' showing total 16 results
Start Over Author "Cheng, Shu" Journal frontiers in oncology
16 results on '"Cheng, Shu"'

1. Surgical outcomes of hepatocellular carcinoma with extrahepatic bile duct tumor thrombus: a multicenter study

Author

Huang, Li-Ming, primary, Zeng, Zhen-Xin, additional, Wu, Jun-Yi, additional, Li, Yi-Nan, additional, Wang, Jin-Xiu, additional, Fu, Yang-Kai, additional, Wu, Jia-Yi, additional, Wei, Shao-Ming, additional, Lv, Jia-Hui, additional, Chen, Wei-Zhao, additional, Huang, Rong-Fa, additional, Cheng, Shu-Qun, additional, and Yan, Mao-Lin, additional

Published
2023
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3. Impact of type 2 diabetes mellitus on the prognosis of patients with hepatocellular carcinoma after laparoscopic liver resection: A multicenter retrospective study

Author

Yang, Shi-Ye, primary, Yan, Mao-Lin, additional, Feng, Jin-Kai, additional, Duan, Yun-Fei, additional, Ye, Jia-Zhou, additional, Liu, Zong-Han, additional, Guo, Lei, additional, Xue, Jie, additional, Shi, Jie, additional, Lau, Wan Yee, additional, Cheng, Shu-Qun, additional, and Guo, Wei-Xing, additional

Published
2022
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4. Efficacy and safety of transarterial chemoembolization plus antiangiogenic- targeted therapy and immune checkpoint inhibitors for unresectable hepatocellular carcinoma with portal vein tumor thrombus in the real world

Author

Feng, Jin-Kai, primary, Liu, Zong-Han, additional, Fu, Zhi-Gang, additional, Chai, Zong-Tao, additional, Sun, Ju-Xian, additional, Wang, Kang, additional, Cheng, Yu-Qiang, additional, Zhu, Hong-Fei, additional, Xiang, Yan-Jun, additional, Zhou, Li-Ping, additional, Shi, Jie, additional, Guo, Wei-Xing, additional, Zhai, Jian, additional, and Cheng, Shu-Qun, additional

Published
2022
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5. Enhanced lipid metabolism confers the immunosuppressive tumor microenvironment in CD5-positive non-MYC/BCL2 double expressor lymphoma

Author

Liu, Meng-Ke, Cheng, Li-Li, Yi, Hong-Mei, He, Yang, Li, Xiao, Fu, Di, Dai, Yu-Ting, Fang, Hai, Cheng, Shu, Xu, Peng-Peng, Qian, Ying, Feng, Yan, Liu, Qian, Wang, Li, and Zhao, Wei-Li

Subjects
Cancer Research, Oncology
Abstract

Lymphoma cells expressing CD5 (CD5+) confer inferior outcome of diffuse large B-cell lymphoma (DLBCL), especially in non–MYC/BCL2 double expressor (non-DE) patients. In tumor microenvironment, CD5+ non-DE tumor revealed increased proportion of immunosuppressive M2 macrophages and enhanced pathways related to macrophage activation and migration. In accordance to M2 activation, lipid metabolism was upregulated, including fatty acid uptake and fatty acid oxidation, which supplied energy for M2 macrophage polarization and activation. Meanwhile, CD36 expression was upregulated and strongly correlated to the proportion of M2 macrophages in CD5+ non-DE DLBCL. In vitro, a DLBCL cell line (LY10) overexpressing CD5 significantly increased M2 proportion in comparison with control when cocultured with peripheral blood mononuclear cells (PBMCs). The addition of metformin significantly decreased the M2 proportion and the CD36 expression level in the coculture systems, indicating that metformin could target altered lipid metabolism and decrease M2 macrophages in DLBCL, especially in CD5+ non-DE lymphoma. In conclusion, enhanced lipid metabolism and M2 macrophage activation contributed to the immunosuppressive tumor microenvironment and could be potential therapeutic targets in CD5+ non-DE DLBCL.

Published
2022

6. Effects of Stereotactic Body Radiation Therapy Plus PD-1 Inhibitors for Patients With Transarterial Chemoembolization Refractory

Author

Xiang, Yan-Jun, primary, Wang, Kang, additional, Zheng, Yi-Tao, additional, Feng, Shuang, additional, Yu, Hong-Ming, additional, Li, Xiao-Wei, additional, Cheng, Xi, additional, Cheng, Yu-Qiang, additional, Feng, Jin-Kai, additional, Zhou, Li-Ping, additional, Meng, Yan, additional, Zhai, Jian, additional, Shan, Yun-Feng, additional, and Cheng, Shu-Qun, additional

Published
2022
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7. Prognostic Comparison Between Liver Resection and Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Bile Duct Tumor Thrombus: A Propensity-Score Matching Analysis

Author

Liu, Zong-Han, primary, Sun, Ju-Xian, additional, Feng, Jin-Kai, additional, Yang, Shi-Ye, additional, Chen, Zhen-Hua, additional, Liu, Chang, additional, Chai, Zong-Tao, additional, Mao, Fei-Fei, additional, Guo, Wei-Xing, additional, Shi, Jie, additional, and Cheng, Shu-Qun, additional

Published
2022
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10. Integrated Genomic and Transcriptomic Analyses of Diffuse Large B-Cell Lymphoma With Multiple Abnormal Immunologic Markers

Author

Sheng, Lingshuang, Fu, Di, Cao, Yiwen, Huo, Yujia, Wang, Shuo, Shen, Rong, Xu, Pengpeng, Cheng, Shu, Wang, Li, and Zhao, Weili

Subjects
Cancer Research, immune abnormalities, Oncology, hemic and lymphatic diseases, oxidative phosphorylation, DLBCL—diffuse large B-cell lymphoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, cell cycle, omic analyses, immune response, RC254-282
Abstract

BackgroundDiffuse large B-cell lymphoma (DLBCL) is a highly aggressive subtype of lymphoma and related to autoimmune diseases (AIDs). Primary B-cell receptor-mediated AIDs are associated with poor clinical outcome of DLBCL. To further determine the role of immunological alterations on disease progression, our study integrated genomic and transcriptomic analyses on DLBCL with multiple abnormal immunologic markers.MethodsThe clinical data of 1,792 patients with newly diagnosed DLBCL were collected, with DNA- and RNA-sequencing conducted for 164 and 127 patients, respectively. Frequent gene mutations and the involved dysregulated pathways, along with gene expression pattern and tumor microenvironment alternations, were analyzed and compared based on the immune status of the patients.ResultsDLBCL with multiple abnormal immunologic markers demonstrated a variety of characteristics including elevated serum lactic dehydrogenase level, inferior prognosis, and dysregulated cell cycle and immune response, as well as activated oxidative phosphorylation pathway and increased Th1/Th2 and Th17/Treg ratios, which were highly similar as those that occur in AIDs.ConclusionsWe piloted the description of the clinical and genetic features of DLBCL with multiple abnormal immunologic markers, illustrated possible mechanisms of disease progression, and provided a clinical rationale of mechanism-based targeted therapy in this subset of DLBCL.

Published
2021

11. Molecular Heterogeneity in Localized Diffuse Large B-Cell Lymphoma

Author

Qin, Wei, primary, Fu, Di, additional, Shi, Qing, additional, Dong, Lei, additional, Yi, Hongmei, additional, Huang, Hengye, additional, Jiang, Xufeng, additional, Song, Qi, additional, Liu, Zhenhua, additional, Cheng, Shu, additional, Huang, Jinyan, additional, Wang, Li, additional, Xu, Pengpeng, additional, and Zhao, Weili, additional

Published
2021
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12. Association of Preoperative Coagulability With Incidence and Extent of Portal Vein Tumor Thrombus and Survival Outcomes in Hepatocellular Carcinoma After Hepatectomy: A Large-Scale, Multicenter Study

Author

Zhang, Xiu-Ping, primary, Zhou, Teng-Fei, additional, Feng, Jin-Kai, additional, Sun, Zi-Yang, additional, Zhen, Zuo-Jun, additional, Zhou, Dong, additional, Zhang, Fan, additional, Hu, Yi-Ren, additional, Zhong, Cheng-Qian, additional, Chen, Zhen-Hua, additional, Chai, Zong-Tao, additional, Wang, Kang, additional, Shi, Jie, additional, Guo, Wei-Xing, additional, Wu, Meng-Chao, additional, Lau, Wan Yee, additional, and Cheng, Shu-Qun, additional

Published
2021
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14. Comparison of Nasopharyngeal MR, 18 F-FDG PET/CT, and 18 F-FDG PET/MR for Local Detection of Natural Killer/T-Cell Lymphoma, Nasal Type

Author

Guo, Rui, primary, Xu, Pengpeng, additional, Cheng, Shu, additional, Lin, Mu, additional, Zhong, Huijuan, additional, Li, Weixia, additional, Huang, Hengye, additional, Ouyang, Bingsheng, additional, Yi, Hongmei, additional, Chen, Jiayi, additional, Lin, Xiaozhu, additional, Shi, Kuangyu, additional, Zhao, Weili, additional, and Li, Biao, additional

Published
2020
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16. Comparison of Nasopharyngeal MR, 18 F-FDG PET/CT, and 18 F-FDG PET/MR for Local Detection of Natural Killer/T-Cell Lymphoma, Nasal Type.

Author

Guo, Rui, Xu, Pengpeng, Cheng, Shu, Lin, Mu, Zhong, Huijuan, Li, Weixia, Huang, Hengye, Ouyang, Bingsheng, Yi, Hongmei, Chen, Jiayi, Lin, Xiaozhu, Shi, Kuangyu, Zhao, Weili, and Li, Biao

Subjects
LYMPHOMAS, PETS, DIFFUSION coefficients
Abstract

Objectives: The present study aims to compare the diagnostic efficacy of MR, 18F-FDG PET/CT, and 18F-FDG PET/MR for the local detection of early-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL). Patients and Methods: Thirty-six patients with histologically proven early-stage ENKTL were enrolled from a phase 2 study (Cohort A). Eight nasopharyngeal anatomical regions from each patient were imaged using 18F-FDG PET/CT and MR. A further nine patients were prospectively enrolled from a multicenter, phase 3 study; these patients underwent 18F-FDG PET/CT and PET/MR after a single 18F-FDG injection (Cohort B). Region-based sensitivity and specificity were calculated. The standardized uptake values (SUV) obtained from PET/CT and PET/MR were compared, and the relationship between the SUV and apparent diffusion coefficients (ADC) of PET/MR were analyzed. Results: In Cohort A, of the 288 anatomic regions, 86 demonstrated lymphoma involvement. All lesions were detected by 18F-FDG PET/CT, while only 70 were detected by MR. 18F-FDG PET/CT exhibited a higher sensitivity than MR (100% vs. 81.4%, χ2 = 17.641, P < 0.001) for local detection of malignancies. The specificity of 18F-FDG PET/CT and MR were 98.5 and 97.5%, respectively (χ2 = 0.510, P = 0.475). The accuracy of 18F-FDG PET/CT was 99.0% and the accuracy of MR was 92.7% (χ2 = 14.087, P < 0.001). In Cohort B, 72 anatomical regions were analyzed. PET/CT and PET/MR have a sensitivity of 100% and a specificity of 92.5%. The two methods were consistent (κ = 0.833, P < 0.001). There was a significant correlation between PET/MR SUVmax and PET/CT SUVmax (r = 0.711, P < 0.001), and SUVmean (r = 0.685, P < 0.001). No correlation was observed between the SUV and the ADC. Conclusion: In early-stage ENKTL, nasopharyngeal MR showed a lower sensitivity and a similar specificity when compared with 18F-FDG PET/CT. PET/MR showed similar performance compared with PET/CT. [ABSTRACT FROM AUTHOR]

Published
2020
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