1. The role of G protein-coupled estrogen receptor 1 on neurological disorders
- Author
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Julieta Mendes-Oliveira, Graça Baltazar, Cláudio Roque, and C. Duarte-Chendo
- Subjects
Male ,0301 basic medicine ,Aging ,Multiple Sclerosis ,Autism Spectrum Disorder ,Estrogen receptor ,Neuroprotection ,Receptors, G-Protein-Coupled ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Animals ,Humans ,Medicine ,Receptor ,Spinal Cord Injuries ,Mood Disorders ,Endocrine and Autonomic Systems ,business.industry ,Parkinson Disease ,medicine.disease ,030104 developmental biology ,Receptors, Estrogen ,Mood disorders ,G-Protein Coupled Estrogen Receptor 1 ,Female ,Signal transduction ,business ,GPER ,Neuroscience ,030217 neurology & neurosurgery ,Signal Transduction - Abstract
G protein-coupled estrogen receptor 1 (GPER) is a membrane-associated estrogen receptor (ER) associated with rapid estrogen-mediated effects. Over recent years GPER emerged has a potential therapeutic target to induce neuroprotection, avoiding the side effects elicited by the activation of classical ERs. The putative neuroprotection triggered by GPER selective activation was demonstrated in mood disorders, Alzheimer's disease or Parkinson's disease of male and female in vivo rodent models. In others, like ischemic stroke, the results are contradictory and currently there is no consensus on the role played by this receptor. However, it seems clear that sex is a biological variable that may impact the results. The major objective of this review is to provide an overview about the physiological effects of GPER in the brain and its putative contribution in neurodegenerative disorders, discussing the data about the signaling pathways involved, as well as, the diverse effects observed.
- Published
- 2019