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64 Cu and 67 Cu are theragnostic pair radionuclides with promising application in the nuclear medicine. 64 Cu is PET nuclide for the non-invasive diagnosis and 67 Cu is beta emitter for therapy of various cancers. This study discusses optimization efforts in the production of these radioactive coppers carried out with 30 MeV cyclotron. Optimized conditions include target preparation, chemical separation, and quality control. The production routes of 64 Cu and 67 Cu were studied based on the nuclear reactions of 64 Ni(p,n) 64 Cu and 70 Zn(p,α) 67 Cu. The produced 64 Cu and 67 Cu have >99.9% of the radionuclidic purity. The yield at the end of bombardment (EOB) of 64 Cu and 67 Cu is 28.5 MBq/μAh and 67 Cu is 0.58 MBq/μAh, respectively., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Lee, Chae, Hur, Yang, Kong, Lee, Ju, Choi and Park.)