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This pilot study aimed to evaluate a continuous glucose monitoring (CGM) based approach to study the effects of a functional drink containing specific amino acids and chromium picolinate (FD) and a combination of FD with a juice (FDJ) on postprandial glucose in a close to real life setting. The predefined primary endpoint for this study was the 120-min incremental area under the glucose curve (iAUC 0-120 min ) after meals. It was estimated that using CGM and repeated meals in 6 participants could be sufficient to match the power of the previous study in regards to the quantity of meals. Participants followed a pre-specified meal schedule over 9 days and consumed the drinks three times daily with main meals. Differences between drinks were analyzed by analysis of covariances (ANCOVA) with subject number and activity as random factors and nutrient composition as covariates. In 156 meals available for analysis, a significant 34% reduction of glucose iAUC 0-120 min was shown for FDJ ( p < 0.001). FD did not show a significant effect on its own, but a significant reduction of 17.6% ( p = 0.007) was shown in pooled data for FD and FDJ. While the differences between the two functional drinks used were not the primary focus of this study, it was sufficiently powered to detect previously described effects in 60 participants in a cross-over design under laboratory settings. The design presented defines a novel and cost-effective approach using CGM devices and app-based lifestyle tracking for studying nutritional effects on glucose at home in a close to real-life setting., Competing Interests: This study received funding from Double Good AB. The funder had the following involvement with the study: EÖ is co-inventor of the patent family describing the functional drink studied, and works for Aventure AB/Double Good AB, that has a license to use the patent. starScience GmbH AS and PH have received funding for other studies by Aventure AB/Double Good AB. PH holds shares of Double Good AB. AS is employed by starScience GmbH., (Copyright © 2022 Samigullin, Humpert and Östman.)