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Your search keyword '"Zeng, Zhan"' showing total 7 results
Start Over Author "Zeng, Zhan" Journal frontiers in immunology
7 results on '"Zeng, Zhan"'

1. Effects of hepatitis B virus infection and strategies for preventing mother-to-child transmission on maternal and fetal T-cell immunity

Author

Lu, Huihui, primary, Cao, Weihua, additional, Zhang, Luxue, additional, Yang, Liu, additional, Bi, Xiaoyue, additional, Lin, Yanjie, additional, Deng, Wen, additional, Jiang, Tingting, additional, Sun, Fangfang, additional, Zeng, Zhan, additional, Lu, Yao, additional, Zhang, Lu, additional, Liu, Ruyu, additional, Gao, Yuanjiao, additional, Wu, Shuling, additional, Hao, Hongxiao, additional, Chen, Xiaoxue, additional, Hu, Leiping, additional, Xu, Mengjiao, additional, Xiong, Qiqiu, additional, Dong, Jianping, additional, Song, Rui, additional, Li, Minghui, additional, and Xie, Yao, additional

Published
2023
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2. Study on pathological and clinical characteristics of chronic HBV infected patients with HBsAg positive, HBV DNA negative, HBeAg negative

Author

Zeng, Zhan, primary, Liu, Ruyu, additional, Cao, Weihua, additional, Yang, Liu, additional, Lin, Yanjie, additional, Bi, Xiaoyue, additional, Jiang, Tingting, additional, Deng, Wen, additional, Wang, Shiyu, additional, Lu, Huihui, additional, Sun, Fangfang, additional, Shen, Ge, additional, Chang, Min, additional, Lu, Yao, additional, Wu, Shuling, additional, Hao, Hongxiao, additional, Xu, Mengjiao, additional, Chen, Xiaoxue, additional, Hu, Leiping, additional, Zhang, Lu, additional, Wan, Gang, additional, Xie, Yao, additional, and Li, Minghui, additional

Published
2023
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3. Sustained viral response and relapse after discontinuation of oral antiviral drugs in HBeAg-positive patients with chronic hepatitis B infection

Author

Sun, Fangfang, primary, Li, Zhenhua, additional, Hu, Leiping, additional, Deng, Wen, additional, Jiang, Tingting, additional, Wang, Shiyu, additional, Bi, Xiaoyue, additional, Lu, Huihui, additional, Yang, Liu, additional, Lin, Yanjie, additional, Zeng, Zhan, additional, Shen, Ge, additional, Liu, Ruyu, additional, Chang, Min, additional, Wu, Shuling, additional, Gao, Yuanjiao, additional, Hao, Hongxiao, additional, Xu, Mengjiao, additional, Chen, Xiaoxue, additional, Zhang, Lu, additional, Lu, Yao, additional, Dong, Jianping, additional, Xie, Yao, additional, and Li, Minghui, additional

Published
2022
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4. Study on liver histopathology of chronic HBV infected patients with different normal ALT values

Author

Zeng, Zhan, primary, Hao, Hongxiao, additional, Bi, Xiaoyue, additional, Lin, Yanjie, additional, Yang, Liu, additional, Wang, Shiyu, additional, Shen, Ge, additional, Chang, Min, additional, Jiang, Tingting, additional, Deng, Wen, additional, Lu, Huihui, additional, Sun, Fangfang, additional, Lu, Yao, additional, Gao, Yuanjiao, additional, Liu, Ruyu, additional, Xu, Mengjiao, additional, Chen, Xiaoxue, additional, Hu, Leiping, additional, Zhang, Lu, additional, Li, Minghui, additional, and Xie, Yao, additional

Published
2022
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5. The relation of the frequency and functional molecules expression on plasmacytoid dendritic cells to postpartum hepatitis in women with HBeAg-positive chronic hepatitis B virus infection

Author

Wang, Fuchuan, primary, Song, Meiying, additional, Hu, Yuhong, additional, Yang, Liu, additional, Bi, Xiaoyue, additional, Lin, Yanjie, additional, Jiang, Tingting, additional, Deng, Wen, additional, Wang, Shiyu, additional, Sun, Fangfang, additional, Zeng, Zhan, additional, Lu, Yao, additional, Shen, Ge, additional, Liu, Ruyu, additional, Chang, Min, additional, Wu, Shuling, additional, Gao, Yuanjiao, additional, Hao, Hongxiao, additional, Xu, Mengjiao, additional, Chen, Xiaoxue, additional, Hu, Leiping, additional, Wan, Gang, additional, Zhang, Lu, additional, Li, Minghui, additional, and Xie, Yao, additional

Published
2022
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6. Dynamic Changes of Cytokine Profiles and Virological Markers Associated With HBsAg Loss During Peginterferon Alpha-2a Treatment in HBeAg-Positive Chronic Hepatitis B Patients

Author

Li, Minghui, Zhang, Luxue, Xie, Si, Sun, Fangfang, Zeng, Zhan, Deng, Wen, Jiang, Tingting, Bi, Xiaoyue, Lin, Yanjie, Yang, Liu, Lu, Yao, Shen, Ge, Liu, Ruyu, Wu, Shuling, Chang, Min, Hu, Leiping, Dong, Jianping, Yi, Wei, and Xie, Yao

Subjects
Hepatitis B Surface Antigens, Immunology, Interferon-alpha, Recombinant Proteins, Interleukin-10, Polyethylene Glycols, Hepatitis B, Chronic, DNA, Viral, Cytokines, Humans, Immunology and Allergy, Hepatitis B e Antigens, Prospective Studies, Hepatitis B Antibodies, Biomarkers
Abstract

ObjectiveTo explore dynamic changes of cytokines and virological markers associated with hepatitis B surface antigen (HBsAg) loss during peginterferon alpha-2a (PEG-IFN α-2a) treatment in hepatitis B e antigen (HBeAg) positive chronic hepatitis B (CHB) patients.MethodsIt was a single-center prospective cohort study. HBeAg-positive CHB patients were prospectively and consecutively enrolled. Cytokines were detected at baseline, week 12 and 24 of PEG-IFN treatment. HBsAg disappearance rate was the primary evaluation index at 48 weeks of PEG-IFN treatment.ResultsAmong 100 patients who completed the 48-week PEG-IFN α-2a treatment, 38 patients achieved serum HBeAg disappearance, 25 patients achieved HBeAg seroconversion, 9 patients achieved functional cure, 37 patients had HBsAg decline of ≥1 log IU/ml, and 8 patients produced hepatitis B surface antibody (HBsAb). Albumin (ALB), fms-like tyrosine kinase 3 ligand (FLT3-L) and interferon-alpha2 (IFN-α2) in the clinical cure group were significantly lower than those in the non-clinical-cure group at baseline. After 12 weeks of treatment, HBsAg in the clinical cure group was significantly lower than that in the non-clinical-cure group (median 1.14 vs. 3.45 log10IU/ml, Z=-4.355, P < 0.001). The decrease of HBsAg and hepatitis B virus desoxyribose nucleic acid (HBV DNA) in the clinical cure group was significantly higher than that in non-clinical-cure group (median: HBsAg 1.96 vs. 0.33 log10IU/ml, Z=-4.703, P< 0.001; HBV DNA 4.49 vs.3.13 log10IU/ml, Z=-3.053, P=0.002). The increase of IFN-α2 in the cure group was significantly higher than that in the non-clinical-cure group (497.89 vs. 344.74, Z=-2.126, P=0.034). After 24 weeks of treatment, HBsAg, HBeAg, Flt3-L, and IL-10 in the clinical cure group were significantly lower than those in the non-clinical-cure group (median: HBsAg 0.70 vs. 3.15 log10IU/ml, Z=-4.535, P< 0.001; HBeAg 1.48 vs. 13.72 S/CO, Z = 2.512, P = 0.012; Flt3-l 0.00 vs 2.24 pg/ml, Z = 3.137, P=0.002; IL-10 0.70 vs. 2.71 pg/ml, Z=-4.067, P < 0.001). HBsAg decreased significantly in the clinical cure group compared with non-clinical-cure group (median 3.27 vs. 0.45, Z=-4.463, P < 0.001).ConclusionDynamic changes of cytokines and virology markers during early PEG IFN α-2a treatment were associated with HBsAg loss in HBeAg-positive CHB patients.

Published
2022
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7. Effect of Antiviral Therapy During Pregnancy on Natural Killer Cells in Pregnant Women With Chronic HBV Infection

Author

Wang, Fuchuan, primary, Xie, Si, additional, Ran, Chongping, additional, Hao, Hongxiao, additional, Jiang, Tingting, additional, Deng, Wen, additional, Bi, Xiaoyue, additional, Lin, Yanjie, additional, Yang, Liu, additional, Sun, Fangfang, additional, Zeng, Zhan, additional, Xie, Yao, additional, Li, Minghui, additional, and Yi, Wei, additional

Published
2022
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