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Your search keyword '"Yassine, Hadi M."' showing total 7 results
Start Over Author "Yassine, Hadi M." Journal frontiers in immunology
7 results on '"Yassine, Hadi M."'

1. Metabolic predictors of COVID-19 mortality and severity: a survival analysis

Author

Abdallah, Abdallah Musa, primary, Doudin, Asmma, additional, Sulaiman, Theeb Osama, additional, Jamil, Omar, additional, Arif, Rida, additional, Sada, Fatima Al, additional, Yassine, Hadi M., additional, Elrayess, Mohamed A., additional, Elzouki, Abdel-Naser, additional, Emara, Mohamed M., additional, Thillaiappan, Nagendra Babu, additional, and Cyprian, Farhan S., additional

Published
2024
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2. Mutational analysis of SARS-CoV-2 ORF6-KPNA2 binding interface and identification of potent small molecule inhibitors to recuse the host immune system.

Author

Suleman, Muhammad, Said, Afsheen, Khan, Haji, Ur Rehman, Shoaib, Alshammari, Abdulrahman, Crovella, Sergio, and Yassine, Hadi M.

Subjects
SARS-CoV-2, SMALL molecules, IMMUNE system, COVID-19 pandemic
Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surfaced on 31 December, 2019, and was identified as the causative agent of the global COVID-19 pandemic, leading to a pneumonia-like disease. One of its accessory proteins, ORF6, has been found to play a critical role in immune evasion by interacting with KPNA2 to antagonize IFN signaling and production pathways, resulting in the inhibition of IRF3 and STAT1 nuclear translocation. Since various mutations have been observed in ORF6, therefore, a comparative binding, biophysical, and structural analysis was used to reveal how these mutations affect the virus's ability to evade the human immune system. Among the identifiedmutations, the V9F, V24A,W27L, and I33T, were found to have a highly destabilizing effect on the protein structure of ORF6. Additionally, the molecular docking analysis of wildtype andmutant ORF6 and KPNA2 revealed the docking score of - 53.72 kcal/mol for wildtype while, -267.90 kcal/mol, -258.41kcal/mol, -254.51 kcal/mol and -268.79 kcal/mol for V9F, V24A, W27L, and I33T respectively. As compared to the wildtype the V9F showed a stronger binding affinity with KPNA2 which is further verified by the binding free energy (-42.28 kcal/mol) calculation. Furthermore, to halt the binding interface of the ORF6-KPNA2 complex, we used a computational molecular search of potential natural products. A multi-step virtual screening of the African natural database identified the top 5 compounds with best docking scores of -6.40 kcal/mol, -6.10 kcal/mol, -6.09 kcal/mol, -6.06 kcal/mol, and -6.03 kcal/mol for tophit1-5 respectively. Subsequent all-atoms simulations of these top hits revealed consistent dynamics, indicating their stability and their potential to interact effectively with the interface residues. In conclusion, our study represents the first attempt to establish a foundation for understanding the heightened infectivity of new SARS-CoV-2 variants and provides a strong impetus for the development of novel drugs against them. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Persistence of spike-specific immune responses in BNT162b2-vaccinated donors and generation of rapid ex-vivo T cells expansion protocol for adoptive immunotherapy: A pilot study

Author

Mestiri, Sarra, primary, Merhi, Maysaloun, additional, Inchakalody, Varghese P., additional, Taib, Nassiba, additional, Smatti, Maria K., additional, Ahmad, Fareed, additional, Raza, Afsheen, additional, Ali, Fatma H., additional, Hydrose, Shereena, additional, Fernandes, Queenie, additional, Ansari, Abdul W., additional, Sahir, Fairooz, additional, Al-Zaidan, Lobna, additional, Jalis, Munir, additional, Ghoul, Mokhtar, additional, Allahverdi, Niloofar, additional, Al Homsi, Mohammed U., additional, Uddin, Shahab, additional, Jeremijenko, Andrew Martin, additional, Nimir, Mai, additional, Abu-Raddad, Laith J., additional, Abid, Fatma Ben, additional, Zaqout, Ahmed, additional, Alfheid, Sameer R., additional, Saqr, Hassan Mohamed Hassan, additional, Omrani, Ali S., additional, Hssain, Ali Ait, additional, Al Maslamani, Muna, additional, Yassine, Hadi M., additional, and Dermime, Said, additional

Published
2023
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5. Effects of SARS-CoV-2 Alpha, Beta, and Delta variants, age, vaccination, and prior infection on infectiousness of SARS-CoV-2 infections

Author

Qassim, Suelen H., primary, Hasan, Mohammad R., additional, Tang, Patrick, additional, Chemaitelly, Hiam, additional, Ayoub, Houssein H., additional, Yassine, Hadi M., additional, Al-Khatib, Hebah A., additional, Smatti, Maria K., additional, Abdul-Rahim, Hanan F., additional, Nasrallah, Gheyath K., additional, Al-Kuwari, Mohamed Ghaith, additional, Al-Khal, Abdullatif, additional, Coyle, Peter, additional, Gillani, Imtiaz, additional, Kaleeckal, Anvar Hassan, additional, Shaik, Riyazuddin Mohammad, additional, Latif, Ali Nizar, additional, Al-Kuwari, Einas, additional, Jeremijenko, Andrew, additional, Butt, Adeel A., additional, Bertollini, Roberto, additional, Al-Romaihi, Hamad Eid, additional, Al-Thani, Mohamed H., additional, and Abu-Raddad, Laith J., additional

Published
2022
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