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Your search keyword '"Wraith, David C"' showing total 8 results
Start Over Author "Wraith, David C" Journal frontiers in immunology
8 results on '"Wraith, David C"'

1. SARS-CoV-2 Spike- and Nucleoprotein-Specific Antibodies Induced After Vaccination or Infection Promote Classical Complement Activation

Author

Lamerton, Rachel E., primary, Marcial-Juarez, Edith, additional, Faustini, Sian E., additional, Perez-Toledo, Marisol, additional, Goodall, Margaret, additional, Jossi, Siân E., additional, Newby, Maddy L., additional, Chapple, Iain, additional, Dietrich, Thomas, additional, Veenith, Tonny, additional, Shields, Adrian M., additional, Harper, Lorraine, additional, Henderson, Ian R., additional, Rayes, Julie, additional, Wraith, David C., additional, Watson, Steve P., additional, Crispin, Max, additional, Drayson, Mark T., additional, Richter, Alex G., additional, and Cunningham, Adam F., additional

Published
2022
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3. The Mechanism of Action of Antigen Processing Independent T Cell Epitopes Designed for Immunotherapy of Autoimmune Diseases

Author

Shepard, Ella R., primary, Wegner, Anja, additional, Hill, Elaine V., additional, Burton, Bronwen R., additional, Aerts, Sarah, additional, Schurgers, Evelien, additional, Hoedemaekers, Brecht, additional, Ng, Sky T. H., additional, Streeter, Heather B., additional, Jansson, Lotta, additional, and Wraith, David C., additional

Published
2021
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8. Regulation of adaptive immunity; the role of interleukin-10.

Author

Sky Ng, T. H., Britton, Graham J., Hill, Elaine V., Verhagen, Johan, Burton, Bronwen R., and Wraith, David C.

Subjects
CELLULAR mechanics, INTERLEUKIN-10, BIOLOGICAL transport, CLINICAL immunology, IMMUNE system
Abstract

Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and adaptive immune systems. IL-10 is produced by a wide range of cell types, but for the purposes of this review we shall focus on IL-10 secreted by CD4C T cells. Here we describe the importance of IL-10 as a mediator of suppression used by both FoxP3C and FoxP3?? T regulatory cells. Moreover, we discuss the molecular events leading to the induction of IL-10 secretion inT helper cell subsets, where it acts as a pivotal negative feedback mechanism. Finally we discuss how a greater understanding of this principle has allowed for the design of more efficient, antigen-specific immunotherapy strategies to exploit this natural phenomenon clinically [ABSTRACT FROM AUTHOR]

Published
2013
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