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Start Over Author "LUO Ping" Journal frontiers in immunology
6 results on '"LUO Ping"'

2. Immunomodulatory Activity of Mesenchymal Stem Cells in Lupus Nephritis: Advances and Applications

Author

Li, Jicui, Luo, Manyu, Li, Bing, Lou, Yan, Zhu, Yuexin, Bai, Xue, Sun, Baichao, Lu, Xuehong, and Luo, Ping

Subjects
Immunomodulation, Mice, Immunology, Immunity, Animals, Cytokines, Humans, Immunology and Allergy, Mesenchymal Stem Cells, Lupus Nephritis
Abstract

Lupus nephritis (LN) is a significant cause of various acute and chronic renal diseases, which can eventually lead to end-stage renal disease. The pathogenic mechanisms of LN are characterized by abnormal activation of the immune responses, increased cytokine production, and dysregulation of inflammatory signaling pathways. LN treatment is an important issue in the prevention and treatment of systemic lupus erythematosus. Mesenchymal stem cells (MSCs) have the advantages of immunomodulation, anti-inflammation, and anti-proliferation. These unique properties make MSCs a strong candidate for cell therapy of autoimmune diseases. MSCs can suppress the proliferation of innate and adaptive immune cells, such as natural killer cells (NKs), dendritic cells (DCs), T cells, and B cells. Furthermore, MSCs suppress the functions of various immune cells, such as the cytotoxicity of T cells and NKs, maturation and antibody secretion of B cells, maturation and antigen presentation of DCs, and inhibition of cytokine secretion, such as interleukins (ILs), tumor necrosis factor (TNF), and interferons (IFNs) by a variety of immune cells. MSCs can exert immunomodulatory effects in LN through these immune functions to suppress autoimmunity, improve renal pathology, and restore kidney function in lupus mice and LN patients. Herein, we review the role of immune cells and cytokines in the pathogenesis of LN and the mechanisms involved, as well as the progress of research on the immunomodulatory role of MSCs in LN.

Published
2022

3. Immunodominance of Epitopes and Protective Efficacy of HI Antigen Are Differentially Altered Using Different Adjuvants in a Mouse Model of Staphylococcus aureus Bacteremia

Author

Chen, Zhifu, primary, Gou, Qiang, additional, Xiong, Qingshan, additional, Duan, Lianli, additional, Yuan, Yue, additional, Zhu, Jiang, additional, Zou, Jintao, additional, Chen, Longlong, additional, Jing, Haiming, additional, Zhang, Xiaoli, additional, Luo, Ping, additional, Zeng, Hao, additional, Zou, Quanming, additional, Zhao, Zhuo, additional, and Zhang, Jinyong, additional

Published
2021
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4. An Integrative Transcriptomic and Metabolomic Study Revealed That Melatonin Plays a Protective Role in Chronic Lung Inflammation by Reducing Necroptosis

Author

Mao, Kaimin, primary, Luo, Ping, additional, Geng, Wei, additional, Xu, Juanjuan, additional, Liao, Yuhan, additional, Zhong, Hua, additional, Ma, Pei, additional, Tan, Qi, additional, Xia, Hui, additional, Duan, Limin, additional, Song, Siwei, additional, Long, Danling, additional, Liu, Yuqi, additional, Yang, Tinglin, additional, Wu, Yali, additional, and Jin, Yang, additional

Published
2021
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6. Development of Different Methods for Preparing Acinetobacter baumannii Outer Membrane Vesicles Vaccine: Impact of Preparation Method on Protective Efficacy

Author

Li, Sun, primary, Chen, Da-Qun, additional, Ji, Lu, additional, Sun, Si, additional, Jin, Zhe, additional, Jin, Zi-Li, additional, Sun, Hong-Wu, additional, Zeng, Hao, additional, Zhang, Wei-Jun, additional, Lu, Dong-Shui, additional, Luo, Ping, additional, Zhao, An-Ni, additional, Luo, Jiao, additional, Zou, Quan-Ming, additional, and Li, Hai-Bo, additional

Published
2020
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