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Your search keyword '"Ishii, Ken"' showing total 15 results
Start Over Author "Ishii, Ken" Journal frontiers in immunology
15 results on '"Ishii, Ken"'

1. 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation

Author

Temizoz, Burcu, primary, Shibahara, Takayuki, additional, Hioki, Kou, additional, Hayashi, Tomoya, additional, Kobiyama, Kouji, additional, Lee, Michelle Sue Jann, additional, Surucu, Naz, additional, Sag, Erdal, additional, Kumanogoh, Atsushi, additional, Yamamoto, Masahiro, additional, Gursel, Mayda, additional, Ozen, Seza, additional, Kuroda, Etsushi, additional, Coban, Cevayir, additional, and Ishii, Ken J., additional

Published
2024
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2. Safety and immunogenicity of BK-SE36/CpG malaria vaccine in healthy Burkinabe adults and children: a phase 1b randomised, controlled, double-blinded, age de-escalation trial

Author

Ouédraogo, Alphonse, primary, Bougouma, Edith Christiane, additional, Palacpac, Nirianne Marie Q., additional, Houard, Sophie, additional, Nebie, Issa, additional, Sawadogo, Jean, additional, Berges, Gloria D., additional, Soulama, Issiaka, additional, Diarra, Amidou, additional, Hien, Denise, additional, Ouedraogo, Amidou Z., additional, Konaté, Amadou T., additional, Kouanda, Seni, additional, Myoui, Akira, additional, Ezoe, Sachiko, additional, Ishii, Ken J., additional, Sato, Takanobu, additional, D’Alessio, Flavia, additional, Leroy, Odile, additional, Tiono, Alfred B., additional, Cousens, Simon, additional, Horii, Toshihiro, additional, and Sirima, Sodiomon B., additional

Published
2023
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3. A-910823, a squalene-based emulsion adjuvant, induces T follicular helper cells and humoral immune responses via α-tocopherol component

Author

Yoshioka, Yuya, primary, Kobiyama, Kouji, additional, Hayashi, Tomoya, additional, Onishi, Motoyasu, additional, Yanagida, Yosuke, additional, Nakagawa, Takayuki, additional, Hashimoto, Masayuki, additional, Nishinaka, Anri, additional, Hirose, Jun, additional, Asaoka, Yoshiji, additional, Tajiri, Minako, additional, Hayata, Atsushi, additional, Ishida, Satoru, additional, Omoto, Shinya, additional, Nagira, Morio, additional, and Ishii, Ken J., additional

Published
2023
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5. S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Author

Nakagawa, Takayuki, primary, Tanino, Tetsuya, additional, Onishi, Motoyasu, additional, Tofukuji, Soichi, additional, Kanazawa, Takayuki, additional, Ishioka, Yukichi, additional, Itoh, Takeshi, additional, Kugimiya, Akira, additional, Katayama, Kazufumi, additional, Yamamoto, Takuya, additional, Nagira, Morio, additional, and Ishii, Ken J., additional

Published
2021
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6. IL-33 Is Essential for Adjuvant Effect of Hydroxypropyl-β-Cyclodexrin on the Protective Intranasal Influenza Vaccination

Author

Kobari, Shingo, primary, Kusakabe, Takato, additional, Momota, Masatoshi, additional, Shibahara, Takayuki, additional, Hayashi, Tomoya, additional, Ozasa, Koji, additional, Morita, Hideaki, additional, Matsumoto, Kenji, additional, Saito, Hirohisa, additional, Ito, Shuichi, additional, Kuroda, Etsushi, additional, and Ishii, Ken J., additional

Published
2020
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9. DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Author

Hayashi, Tomoya, primary, Momota, Masatoshi, additional, Kuroda, Etsushi, additional, Kusakabe, Takato, additional, Kobari, Shingo, additional, Makisaka, Kotaro, additional, Ohno, Yoshitaka, additional, Suzuki, Yusuke, additional, Nakagawa, Fumika, additional, Lee, Michelle S. J., additional, Coban, Cevayir, additional, Onodera, Risako, additional, Higashi, Taishi, additional, Motoyama, Keiichi, additional, Ishii, Ken J., additional, and Arima, Hidetoshi, additional

Published
2018
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10. Carbonate Apatite Nanoparticles Act as Potent Vaccine Adjuvant Delivery Vehicles by Enhancing Cytokine Production Induced by Encapsulated Cytosine-Phosphate-Guanine Oligodeoxynucleotides

Author

Takahashi, Hideki, primary, Misato, Kazuki, additional, Aoshi, Taiki, additional, Yamamoto, Yasuyuki, additional, Kubota, Yui, additional, Wu, Xin, additional, Kuroda, Etsushi, additional, Ishii, Ken J., additional, Yamamoto, Hirofumi, additional, and Yoshioka, Yasuo, additional

Published
2018
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14. T helper 17 Promotes induction of antigen-specific gut-Mucosal cytotoxic T lymphocytes following adenovirus Vector Vaccination.

Author

Masahisa Hemmi, Masashi Tachibana, Natsuki Fujimoto, Masaki Shoji, Fuminori Sakurai, Kouji Kobiyama, Ishii, Ken J., Shizuo Akira, and Hiroyuki Mizuguchi

Abstract

Few current vaccines can establish antigen (Ag)-specific immune responses in both mucosal and systemic compartments. Therefore, development of vaccines providing defense against diverse infectious agents in both compartments is of high priority in global health. Intramuscular vaccination of an adenovirus vector (Adv) has been shown to induce Ag-specific cytotoxic T lymphocytes (CTLs) in both systemic and gut-mucosal compartments. We previously found that type I interferon (IFN) signaling is required for induction of gut-mucosal, but not systemic, CTLs following vaccination; however, the molecular mechanism involving type I IFN signaling remains unknown. Here, we found that T helper 17 (Th17)-polarizing cytokine expression was down-regulated in the inguinal lymph nodes (iLNs) of Ifnar2-/- mice, resulting in the reduction of Ag-specific Th17 cells in the iLNs and gut mucosa of the mice. We also found that prior transfer of Th17 cells reversed the decrease in the number of Ag-specific gut-mucosal CTLs in Ifnar2-/- mice following Adv vaccination. Additionally, prior transfer of Th17 cells into wild-type mice enhanced the induction of Ag-specific CTLs in the gut mucosa, but not in systemic compartments, suggesting a gut mucosa-specific mechanism where Th17 cells regulate the magnitude of vaccine-elicited Ag-specific CTL responses. These data suggest that Th17 cells translate systemic type I IFN signaling into a gut-mucosal CTL response following vaccination, which could promote the development of promising Adv vaccines capable of establishing both systemic and gut-mucosal protective immunity. [ABSTRACT FROM AUTHOR]

Published
2017
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15. Allergic Responses induced by the immunomodulatory effects of Nanomaterials upon Skin exposure.

Author

Yasuo Yoshioka, Etsushi Kuroda, Toshiro Hirai, Yasuo Tsutsumi, and Ishii, Ken J.

Subjects
ALLERGIES, IMMUNOMODULATORS, NANOSTRUCTURED materials
Abstract

Over the past decade, a vast array of nanomaterials has been created through the development of nanotechnology. With the increasing application of these nanomaterials in various fields, such as foods, cosmetics, and medicines, there has been concern about their safety, that is, nanotoxicity. Therefore, there is an urgent need to collect information about the biological effects of nanomaterials so that we can exploit their potential benefits and design safer nanomaterials, while avoiding nanotoxicity as a result of inhalation or skin exposure. In particular, the immunomodulating effect of nanomaterials is one of most interesting aspects of nanotoxicity. However, the immunomodulating effects of nanomaterials through skin exposure have not been adequately discussed compared with the effects of inhalation exposure, because skin penetration by nanomaterials is thought to be extremely low under normal conditions. On the other hand, the immunomodulatory effects of nanomaterials via skin may cause severe problems for people with impaired skin barrier function, because some nanomaterials could penetrate the deep layers of their allergic or damaged skin. In addition, some studies, including ours, have shown that nanomaterials could exhibit significant immunomodulating effects even if they do not penetrate the skin. In this review, we summarize our current knowledge of the allergic responses induced by nanomaterials upon skin exposure. First, we discuss nanomaterial penetration of the intact or impaired skin barrier. Next, we describe the immunomodulating effects of nanomaterials, focusing on the sensitization potential of nanomaterials and the effects of co-exposure of nanomaterials with substances such as chemical sensitizers or allergens, on the onset of allergy, following skin exposure. Finally, we discuss the potential mechanisms underlying the immunomodulating effects of nanomaterials by describing the involvement of the protein corona in the interaction of nanomaterials with biological components and by presenting recent data about the adjuvant effects of well-characterized particle adjuvant, aluminum salt, as an example of immunomodulatory particulate. [ABSTRACT FROM AUTHOR]

Published
2017
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