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Your search keyword '"Beeckmans, Hanne"' showing total 4 results
Start Over Author "Beeckmans, Hanne" Journal frontiers in immunology
4 results on '"Beeckmans, Hanne"'

1. The nature of chronic rejection after lung transplantation: a murine orthotopic lung transplant study

Author

Heigl, Tobias, primary, Kaes, Janne, additional, Aelbrecht, Celine, additional, Serré, Jef, additional, Yamada, Yoshito, additional, Geudens, Vincent, additional, Van Herck, Anke, additional, Vanstapel, Arno, additional, Sacreas, Annelore, additional, Ordies, Sofie, additional, Frick, Anna, additional, Saez Gimenez, Berta, additional, Van Slambrouck, Jan, additional, Beeckmans, Hanne, additional, Acet Oztürk, Nilüfer A., additional, Orlitova, Michaela, additional, Vaneylen, Annemie, additional, Claes, Sandra, additional, Schols, Dominique, additional, Vande Velde, Greetje, additional, Schupp, Jonas, additional, Kaminski, Naftali, additional, Boesch, Markus, additional, Korf, Hannelie, additional, van der Merwe, Schalk, additional, Dupont, Lieven, additional, Vanoirbeek, Jeroen, additional, Godinas, Laurent, additional, Van Raemdonck, Dirk E., additional, Janssens, Wim, additional, Gayan-Ramirez, Ghislaine, additional, Ceulemans, Laurens J., additional, McDonough, John E., additional, Verbeken, Erik K., additional, Vos, Robin, additional, and Vanaudenaerde, Bart M., additional

Published
2024
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2. Mucosal immune alterations at the early onset of tissue destruction in chronic obstructive pulmonary disease

Author

de Fays, Charlotte, primary, Geudens, Vincent, additional, Gyselinck, Iwein, additional, Kerckhof, Pieterjan, additional, Vermaut, Astrid, additional, Goos, Tinne, additional, Vermant, Marie, additional, Beeckmans, Hanne, additional, Kaes, Janne, additional, Van Slambrouck, Jan, additional, Mohamady, Yousry, additional, Willems, Lynn, additional, Aversa, Lucia, additional, Cortesi, Emanuela E., additional, Hooft, Charlotte, additional, Aerts, Gitte, additional, Aelbrecht, Celine, additional, Everaerts, Stephanie, additional, McDonough, John E., additional, De Sadeleer, Laurens J., additional, Gohy, Sophie, additional, Ambroise, Jerome, additional, Janssens, Wim, additional, Ceulemans, Laurens J., additional, Van Raemdonck, Dirk, additional, Vos, Robin, additional, Hackett, Tillie L., additional, Hogg, James C., additional, Kaminski, Naftali, additional, Gayan-Ramirez, Ghislaine, additional, Pilette, Charles, additional, and Vanaudenaerde, Bart M., additional

Published
2023
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3. Allogeneic Hematopoietic Stem Cell Transplantation After Prior Lung Transplantation for Hereditary Pulmonary Alveolar Proteinosis: A Case Report

Author

Beeckmans, Hanne, Ambrocio, Gene PL, Bos, Saskia, Vermaut, Astrid, Geudens, Vincent, Vanstapel, Arno, Vanaudenaerde, Bart M, De Baets, Frans, Malfait, Thomas LA, Emonds, Marie-Paule, Van Raemdonck, Dirk E, Schoemans, Helene M, Vos, Robin, and Leuven, Lung Transplant Grp

Subjects
bone marrow transplantation, pulmonary alveolar proteinosis, Pulmonary Fibrosis, Immunology, Hematopoietic Stem Cell Transplantation, Pulmonary Surfactants, Surface-Active Agents, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, lung transplantation, Quality of Life, Humans, Immunology and Allergy, allogeneic hematopoietic stem cell transplantation, rejection
Abstract

Pulmonary alveolar proteinosis (PAP) is a rare, diffuse lung disorder characterized by surfactant accumulation in the small airways due to defective clearance by alveolar macrophages, resulting in impaired gas exchange. Whole lung lavage is the current standard of care treatment for PAP. Lung transplantation is an accepted treatment option when whole lung lavage or other experimental treatment options are ineffective, or in case of extensive pulmonary fibrosis secondary to PAP. A disadvantage of lung transplantation is recurrence of PAP in the transplanted lungs, especially in hereditary PAP. The hereditary form of PAP is an ultra-rare condition caused by genetic mutations in genes encoding for the granulocyte macrophage-colony stimulating factor (GM-CSF) receptor, and intrinsically affects bone marrow derived-monocytes, which differentiate into macrophages in the lung. Consequently, these macrophages typically display disrupted GM-CSF receptor-signaling, causing defective surfactant clearance. Bone marrow/hematopoietic stem cell transplantation may potentially reverse the lung disease in hereditary PAP. In patients with hereditary PAP undergoing lung transplantation, post-lung transplant recurrence of PAP may theoretically be averted by subsequent hematopoietic stem cell transplantation, which results in a graft-versus-disease (PAP) effect, and thus could improve long-term outcome. We describe the successful long-term post-transplant outcome of a unique case of end-stage respiratory failure due to hereditary PAP-induced pulmonary fibrosis, successfully treated by bilateral lung transplantation and subsequent allogeneic hematopoietic stem cell transplantation. Our report supports treatment with serial lung and hematopoietic stem cell transplantation to improve quality of life and prolong survival, without PAP recurrence, in selected patients with end-stage hereditary PAP. ispartof: FRONTIERS IN IMMUNOLOGY vol:13 ispartof: location:Switzerland status: published

Published
2022

4. Myeloid-Derived Suppressor Cells in Lung Transplantation

Author

Heigl, Tobias, primary, Singh, Anurag, additional, Saez-Gimenez, Berta, additional, Kaes, Janne, additional, Van Herck, Anke, additional, Sacreas, Annelore, additional, Beeckmans, Hanne, additional, Vanstapel, Arno, additional, Verleden, Stijn E., additional, Van Raemdonck, Dirk E., additional, Verleden, Geert, additional, Vanaudenaerde, Bart M., additional, Hartl, Dominik, additional, and Vos, Robin, additional

Published
2019
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