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Start Over Author "Yongxing Xu" Journal frontiers in endocrinology
1 results on '"Yongxing Xu"'

1. Causal effects of serum calcium, phosphate, and 25-hydroxyvitamin D on kidney function: a genetic correlation, pleiotropic analysis, and Mendelian randomization study

Author

Yanjun Liang, Shuang Liang, Dayang Xie, Xinru Guo, Chen Yang, Tuo Xiao, Kaiting Zhuang, Yongxing Xu, Yong Wang, Bin Wang, Zhou Zhang, Xiangmei Chen, Yizhi Chen, and Guangyan Cai

Subjects
calcium, phosphate, 25-hydroxyvitamin D, parathyroid hormone, kidney function, Mendelian randomization, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

BackgroundExisting studies investigating the impact of serum calcium (Ca), phosphate (P), 25 hydroxyvitamin D (25[OH]D), and parathyroid hormone (PTH) levels on kidney function have produced inconsistent results. Further research is needed to establish the direct causal relationship between these factors and kidney function.MethodsThe study used genome-wide association study datasets for exposure and outcome, mainly derived from the UK Biobank and CKDGen Consortium, with sample sizes ranging from 3,310 to 480,699 individuals of European ancestry. Heritability and genetic correlations among these phenotypes were assessed using linkage disequilibrium score regression (LDSC) and phenotypes with a heritability z-score

Published
2024
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