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Your search keyword '"Abdulmohsen Alterki"' showing total 2 results
Start Over Author "Abdulmohsen Alterki" Journal frontiers in endocrinology
2 results on '"Abdulmohsen Alterki"'

1. Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity

Author

M. Leentjens, Abdulmohsen Alterki, Mohamed Abu-Farha, P. F. N. Bosschieter, CAL. de Raaff, CEE. de Vries, Eman Al Shawaf, Thangavel Alphonse Thanaraj, Irina Al-Khairi, Preethi Cherian, Arshad Channanath, Sina Kavalakatt, B. A. van Wagensveld, N. de Vries, and Jehad Abubaker

Subjects
obstructive sleep apnea, ANGPTL7, hypoxia, polysomnography, apnea hypopnea index, bariatric surgery, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

BackgroundWeight-loss surgery is one of the recommended methods for treating obstructive sleep apnea (OSA) in obese patients. While weight reduction is critical to relieve symptoms of OSA, the biochemical factors involved in post-surgery improvement are still unknown. We aimed to explore the link between ANGPTL7 and OSA in patients with different OSA severity. Furthermore, we examined the effect of treating OSA with bariatric surgery on ANGPTL7 level.MethodsWe quantified levels of circulating ANGPTL7 in fasting plasma and adipose tissue samples of 88 participants before and after bariatric surgery. Confocal microscopy analyses were also performed to assess the ANGPTL7 expression in subcutaneous white adipose tissue biopsies obtained from people with moderate-to-severe OSA compared to those with none or mild OSA. The study involved 57 individuals with none or mild OSA and 31 patients with moderate-to-severe OSA.ResultsLevels of circulating ANGPTL7 were significantly higher in people with moderate-to-severe OSA (1440 ± 1310 pg/ml) compared to the none or mild OSA group (734 ± 904 pg/ml, p = 0.01). The increase in ANGPTL7 correlated significantly and positively with the apnea-hypopnea index (AHI, r = .226, p = .037), and AHI-supine (r = .266, p = .019) in participants with moderate-to-severe OSA. Multivariate logistic regression analysis demonstrated an association between ANGPTL7 and OSA severity (log2 ANGPTL7; OR =1.24, p = 0.024). ANGPTL7 levels exhibited significant positive correlations with the levels of TG and oxLDL (p-value = 0.002 and 0.01 respectively). Bariatric surgery reduced the levels of both ANGPTL7 and AHI significantly.ConclusionHere we report significantly increased levels of ANGPTL7 both in the circulation and in adipose tissue of patients with OSA, which concurred with increased inflammation and OSA severity. Levels of ANGPTL7 decreased significantly as OSA showed a significant improvement post-surgery supporting a potential role for ANGPTL7 in either OSA progression or a role in an OSA-related mechanism.

Published
2022
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2. Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea

Author

Preethi Cherian, Irina Al-Khairi, Shamsha Ali, Fahd Al-Mulla, Devarajan Sriraman, Jehad Abubaker, Jaakko Tuomilehto, Ambika Shyamsundar, Abdulmohsen Alterki, and Mohamed Abu-Farha

Subjects
0301 basic medicine, medicine.medical_specialty, Betatrophin, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Polysomnography, Gastroenterology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, apnea hypopnea index, Endocrinology, ANGPTL4, polysomnography, Internal medicine, lipid metabolism, medicine, obstructive sleep apnea, Original Research, Sleep disorder, lcsh:RC648-665, medicine.diagnostic_test, business.industry, Sleep apnea, medicine.disease, Obesity, ANGPTL8, nervous system diseases, respiratory tract diseases, Obstructive sleep apnea, 030104 developmental biology, Apnea–hypopnea index, business
Abstract

Objective: Obstructive sleep apnea (OSA) is a sleep disorder caused by the complete or partial obstruction of the upper airways. The worldwide prevalence of OSA is increasing due to its close association with obesity epidemic and multiple health complications, such as hypertension, cardiovascular disease, and Type 2 diabetes. Angiopoietin-like protein (ANGPTL)-4 and ANGPTL8 (betatrophin) have been suggested to play a role in the development of these diseases through their role in regulating the metabolism of plasma lipid molecules. This study was designed to evaluate ANGPTL4 and 8 levels in an OSA group and a control group to clarify the effect of OSA on ANGPTL4 and 8 levels.Methods: In total, 74 subjects were enrolled in this study, including 22 age- and body mass index (BMI)-matched controls with the Apnea Hypopnea Index (AHI) score of 5 events/h. Sleep apnea was assessed using a portable sleep test. ANGPTL4 and 8 levels were measured in plasma samples using enzyme-linked immunosorbent assay.Results: Mean AHI score (2.5 ± 1.6) in the control group was significantly lower than that in the OSA group (22.9 ± 17.9; p < 0.0001). Leptin, interleukin-(IL) 6, insulin, and HOMA-IR values were higher in the OSA group than in the control group. ANGPTL8 level was higher in the OSA group (1130.0 ± 108.61 pg/mL) than in the control group (809.39 ± 108.78 pg/mL; p = 0.041). Similarly, ANGPTL4 was higher in the OSA group (179.26 ± 12.89 ng/mL) than in the control group (142.63 ±7.99 ng/mL; p = 0.018).Conclusion: Our findings demonstrate that ANGPTL4 and 8 levels were increased in subjects with OSA, suggesting that the upregulation of these lipid metabolism regulators might play a role in lipid dysregulation observed in people with OSA.

Published
2018

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