1. Interactions between bone cells and biomaterials: An update
- Author
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Guillaume Grenier, Sabrina Beauvais, Sophie Roux, Olivier Drevelle, Jessica Jann, Marc-Antoine Lauzon, Nathalie Faucheux, and Mohammadreza Foruzanmehr
- Subjects
Biomimetic materials ,Pathology ,medicine.medical_specialty ,Osteoporosis ,Biocompatible Materials ,02 engineering and technology ,010402 general chemistry ,Bioinformatics ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Bone and Bones ,Biomimetic Materials ,Bone cell ,Medicine ,Animals ,Humans ,Aged ,General Immunology and Microbiology ,business.industry ,Osteomyelitis ,Bone physiology ,Age Factors ,021001 nanoscience & nanotechnology ,medicine.disease ,0104 chemical sciences ,Malignant osteolysis ,0210 nano-technology ,business - Abstract
As the populations of the Western world become older, they will suffer more and more from bone defects related to osteoporosis (non-union fractures, vertebral damages), cancers (malignant osteolysis) and infections (osteomyelitis). Autografts are usually used to fill these defects, but they have several drawbacks such as morbidity at the donor site and the amount and quality of bone that can be harvested. Recent scientific milestones made in biomaterials development were shown to be promising to overcome these limitations. Cell interactions with biomaterials can be improved by adding at their surface functional groups such as adhesive peptides and/or growth factors. The development of such biomimetic materials able to control bone cell responses can only proceed if it is based on a sound understanding of bone cell behavior and regulation. This review focuses on bone physiology and the regulation of bone cell differentiation and function, and how the latest advances in biomimetic materials can be translated within promising clinical outcomes.
- Published
- 2016