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Your search keyword '"Gwoncheol Park"' showing total 2 results
Start Over Author "Gwoncheol Park" Journal frontiers in aging neuroscience
2 results on '"Gwoncheol Park"'

1. Administration of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI Improves Cognitive and Memory Function in the Mouse Model of Alzheimer’s Disease

Author

Hongwon Kim, Sumin Kim, Sang-jun Park, Gwoncheol Park, Hakdong Shin, Myeong Soo Park, and Jongpil Kim

Subjects
Alzheimer’s disease, probiotics, gut microbiota, Bifidobacterium, cognitive and memory impairment, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Recent evidence indicates that gut microbiota could interact with the central nervous system and affect brain function, including cognition and memory. In this study, we investigated whether Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) alleviated the pathological features in a mouse model of Alzheimer’s disease (AD). Administration of B. bifidum BGN4 and B. longum BORI effectively suppressed amyloidosis and apoptotic processes and improved synaptic plasticity by ameliorating the neuroinflammatory response and BDNF expression. Moreover, behavioral tests indicated that B. bifidum BGN4 and B. longum BORI attenuated the cognitive and memory disability of AD mice. Taken together, the present study highlights the therapeutic potential of B. bifidum BGN4 and B. longum BORI for suppressing the pathological features of AD.

Published
2021
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2. Administration of

Author

Hongwon, Kim, Sumin, Kim, Sang-Jun, Park, Gwoncheol, Park, Hakdong, Shin, Myeong Soo, Park, and Jongpil, Kim

Subjects
fluids and secretions, probiotics, gut microbiota, cognitive and memory impairment, food and beverages, Bifidobacterium, digestive system, Alzheimer’s disease, Neuroscience, Original Research
Abstract

Recent evidence indicates that gut microbiota could interact with the central nervous system and affect brain function, including cognition and memory. In this study, we investigated whether Bifidobacterium bifidum BGN4 (B. bifidum BGN4) and Bifidobacterium longum BORI (B. longum BORI) alleviated the pathological features in a mouse model of Alzheimer’s disease (AD). Administration of B. bifidum BGN4 and B. longum BORI effectively suppressed amyloidosis and apoptotic processes and improved synaptic plasticity by ameliorating the neuroinflammatory response and BDNF expression. Moreover, behavioral tests indicated that B. bifidum BGN4 and B. longum BORI attenuated the cognitive and memory disability of AD mice. Taken together, the present study highlights the therapeutic potential of B. bifidum BGN4 and B. longum BORI for suppressing the pathological features of AD.

Published
2021

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