1. Oxidative stress in subjects affected by celiac disease
- Author
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Tommaso Barreca, Patrizio Odetti, Sabina Valentini, I. Aragno, Maria Adelaide Pronzato, Silvano Garibaldi, and Ermanno Rolandi
- Subjects
Adult ,Male ,stress ossidativo ,medicine.medical_specialty ,Antioxidant ,Adolescent ,medicine.medical_treatment ,Disease ,medicine.disease_cause ,Arginine ,Biochemistry ,Asymptomatic ,Thiobarbituric Acid Reactive Substances ,chemistry.chemical_compound ,celiachia ,carbonili proteici ,Internal medicine ,medicine ,TBARS ,Humans ,Vitamin E ,Pentosidine ,Vitamin A ,Lysine ,Retinol ,Case-control study ,General Medicine ,Blood Proteins ,Lipids ,Celiac Disease ,Oxidative Stress ,Endocrinology ,chemistry ,Case-Control Studies ,Female ,medicine.symptom ,Oxidative stress - Abstract
In order to study the role of oxidative stress in celiac disease, protein carbonyl groups, thiobarbituric acid-reactive substance and pentosidine were evaluated in the plasma of nine patients with asymptomatic celiac disease and in a control group (n = 25). Plasma alpha-tocopherol, retinol and lipids were determined in the same samples. The levels of markers of oxidative stress derived from both protein (carbonyl groups) and lipids (thiobarbituric acid-reactive substances) were significantly higher in celiac disease patients, whereas lipoproteins and alpha-tocopherol were significantly lower. These data indicate that in celiac disease, even when asymptomatic, a redox imbalance persists; this is probably caused by an absorption deficiency, even if slight. Dietary supplementation with antioxidant molecules may offer some benefit and deserves further investigation.
- Published
- 1998