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The dynamic behaviour and the seismic vulnerability of the ancient civic clock tower of Amatrice, dramatically damaged by the last shocks sequence of 2016 that occurred in Central Italy, is studied in this paper by means of advanced 3D numerical analyses with the Non-Smooth Contact Dynamics Method (NSCD). Thus, a discontinuous approach was used to assess the dynamic properties and the vulnerability of the masonry structure, through large displacements regulated by the Signorini’s law, concerning the impenetrability between the rigid bodies, and by the Coulomb’s law, regarding the dry-friction model. Afterward, different values were assigned to the friction coefficient of the models and real seismic shocks were then applied in nonlinear analyses. The major purpose of this study is to highlight that relevant data on the real structural behaviour of historical masonry may provided through advanced numerical analyses. The comparison between the results of numerical simulation and survey of the existing crack pattern of the bell tower permitted to validate the selected approach. Finally, from results and conclusions provided by this case study, it is possible to affirm that the used methodology may be applied to a wide variety of historical masonry structure in Europe. [ABSTRACT FROM AUTHOR]