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We investigate the transient dynamics of the Fisher equation under nonlinear diffusion and fractional operators. Firstly, we investigate the effects of the nonlinear diffusivity parameter in the integer-order Fisher equation, by considering a Gaussian distribution as the initial condition. Measuring the spread of the Gaussian distribution by u (0 , t) − 2 , our results show that the solution reaches a steady state governed by the parameters present in the logistic function in Fisher's equation. The initial transient is an anomalous diffusion process, but a power law cannot describe the whole transient. In this sense, the main novelty of this work is to show that a q-exponential function gives a better description of the transient dynamics. In addition to this result, we extend the Fisher equation via non-integer operators. As a fractional definition, we employ the Caputo fractional derivative and use a discretized system for the numerical approach according to finite difference schemes. We consider the numerical solutions in three scenarios: fractional differential operators acting in time, space, and in both variables. Our results show that the time to reach the steady solution strongly depends on the fractional order of the differential operator, with more influence by the time operator. Our main finding shows that a generalized q-exponential, present in the Tsallis formalism, describes the transient dynamics. The adjustment parameters of the q-exponential depend on the fractional order, connecting the generalized thermostatistics with the anomalous relaxation promoted by the fractional operators in time and space. [ABSTRACT FROM AUTHOR]