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This work explores the existence and uniqueness criteria for the solution of hybrid Caputo–Hadamard fractional sequential differential equations (HCHFSDEs) by employing Darbo's fixed-point theorem. Fractional differential equations play a pivotal role in modeling complex phenomena in various areas of science and engineering. The hybrid approach considered in this work combines the advantages of both the Caputo and Hadamard fractional derivatives, leading to a more comprehensive and versatile model for describing sequential processes. To address the problem of the existence and uniqueness of solutions for such hybrid fractional sequential differential equations, we turn to Darbo's fixed-point theorem, a powerful mathematical tool that establishes the existence of fixed points for certain types of mappings. By appropriately transforming the differential equation into an equivalent fixed-point formulation, we can exploit the properties of Darbo's theorem to analyze the solutions' existence and uniqueness. The outcomes of this research expand the understanding of HCHFSDEs and contribute to the growing body of knowledge in fractional calculus and fixed-point theory. These findings are expected to have significant implications in various scientific and engineering applications, where sequential processes are prevalent, such as in physics, biology, finance, and control theory. [ABSTRACT FROM AUTHOR]