1. Analyzing population structure for forensic STR markers in next generation sequencing data.
- Author
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Aalbers SE, Hipp MJ, Kennedy SR, and Weir BS
- Subjects
- Alleles, DNA Fingerprinting, Genotype, Humans, Racial Groups genetics, Genetic Markers, Genetics, Population, High-Throughput Nucleotide Sequencing, Microsatellite Repeats, Sequence Analysis, DNA
- Abstract
Match probabilities calculated during the evaluation of DNA evidence profiles rely on appropriate values of the population structure quantity θ. NGS-based methods will enhance forensic identification and with the transformation to such methods comes the need to facilitate NGS-based population genetics analysis. If NGS data are to be used for match probabilities there needs to be a way to accommodate population structure, which requires values for θ for those data. Such estimates have not been available. This study assesses population structure for sequence-based data using a relatively new approach applied to STR data over 27 loci in five different geographic groups. Matching proportions between individuals or groups are used to obtain locus-specific θ estimates as well as estimates per geographic group and a global measure. The results demonstrate similar effects of sequencing data on θ estimates compared to what has been seen for CE-based results., (Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
- Published
- 2020
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