De Souza, Thais Cristina Lima, Da Silveira, Tayse Ferreira Ferreira, Rodrigues, Maria Isabel, Ruiz, Ana Lucia Tasca Gois, Neves, Daniela Andrade, Duarte, Marta Cristina Teixeira, Cunha-Santos, Elenice Carla Emidio, Kuhnle, Gunter, Ribeiro, Alessandra Braga, and Godoy, Helena Teixeira
• Neglected and underutilized edible species (NUS) are important food sources. • Optimization resulted in extracts with promising antioxidant capacities against ROS. • O. gratissimum extracts effectively inhibited S. Choleraesuis growth. • P. oleracea presented the most promising cytostatic effect against tumor cell lines. • O. gratissimum and E. foetidum inhibited nitrosation reaction. This study investigated the vitamin C content, total phenolic compounds (TPC), and the potential bioactivities (antioxidant, antiproliferative, antibacterial activities, and inhibition capacity against N -nitrosation) of seven neglected and underutilized species (NUS): culantro (Eryngium foetidum) , false roselle (Hibiscus acetosella) , roselle (Hibiscus sabdariffa) , tree basil (Ocimum gratissimum) , Barbados Gooseberry (Pereskia aculeata) , purslane (Portulaca oleracea), and tannia (Xanthosoma sagittifolium). Phenolic-rich extracts were obtained by a sequential optimization strategy (Plackett-Burman and Central Composite Design). O. gratissimum presented the highest TPC and X. sagittifolium the greater total vitamin C content. Overall, the plant extracts presented promising bioactive capacities, as scavenging capacity against HOCl, H 2 O 2 and ROO• induced oxidation. P. oleracea demonstrated the highest cytostatic effect against ovarian and kidney tumor cells. O. gratissimum effectively inhibited S. Choleraesuis growth. Maximum inhibition on n -nitrosation was showed by O. gratissimum and E. foetidum. These results highlight the studied NUS as sources of potential health-promoting compounds. [ABSTRACT FROM AUTHOR]