1. Phthalates exposure indicators determined by urinary phthalate metabolites in healthy non-obese Czech adults: FANTOM study
- Author
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Jana Dvořáková, Karel Vrbík, Kateřina Kovářová, Dana Müllerová, Vendula Bouchalová, Štěpán Svačina, Luděk Müller, Jana Pavloušková, and Dagmar Matějková
- Subjects
0301 basic medicine ,Food intake ,Meat ,Health, Toxicology and Mutagenesis ,Urinary system ,Population ,Phthalic Acids ,Food Contamination ,Urine ,010501 environmental sciences ,Toxicology ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,Non obese ,Tandem Mass Spectrometry ,Humans ,Food science ,education ,Chromatography, High Pressure Liquid ,0105 earth and related environmental sciences ,Czech Republic ,education.field_of_study ,Public Health, Environmental and Occupational Health ,Phthalate ,General Chemistry ,General Medicine ,Healthy Volunteers ,030104 developmental biology ,chemistry ,Fruit ,Glucuronide ,Biomarkers ,Food Science ,Food contaminant - Abstract
It is assumed that human exposure to phthalates may be associated with adverse health effects. The indicators of urinary phthalate metabolite concentrations in healthy adults are limited. In this study, the phthalate metabolites concentrations were detected from 24-h urine collection in non-obese Czech adults (n = 201). Each participant filled in an 80-item questionnaire (FANTOM-SQ 2013) regarding the outdoor and indoor sources of phthalates, the use of personal care products and food intake sources. The concentrations of 15 phthalates metabolites were analysed following enzymatic cleavage of the glucuronide using ultra-high-performance liquid chromatography-electrospray ionisation tandem mass spectrometry (UHPLC-ESI-MS/MS). The indicators of chronic or acute exposure phthalate-containing materials were identified. It is shown that higher fruit consumption was positively and significantly associated with a higher level of total 15 urinary phthalates biomarkers (p
- Published
- 2016