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Your search keyword '"(-)-epigallocatechin-3-gallate (egcg)"' showing total 3 results
Start Over Descriptor "(-)-epigallocatechin-3-gallate (egcg)" Journal folia neuropathologica
3 results on '"(-)-epigallocatechin-3-gallate (egcg)"'

1. Epigallocatechin gallate enhances the motor neuron survival and functional recovery after brachial plexus root avulsion by regulating FIG4

Author

Yinjuan Tang, Jianjun Wang, Shengjie Wan, Lanbing Luo, Yuxia Qiu, Shiyin Jiang, Guihua Yue, Yumei Tang, and Weijun Tang

Subjects
motor neurons, brachial plexus root avulsion, (-)-epigallocatechin-3-gallate (egcg), neurodegenerative diseases, fig4, Medicine
Abstract

The survival of motor neurons (MNs) is the key to recovery of the motor function after brachial plexus root avulsion (BPRA). (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective roles in neurons under different pathological conditions. However, the role of EGCG in regulating motor neurons under BPRA remains to be unclear. In the present study, we investigated the functional role of EGCG both in vitro and in vivo . In an in vitro study, we observed that EGCG obviously increased the cell survival rate of MNs and FIG4 protein levels compared with the vehicle control, with a peak level observed at 50 µM; EGCG can also upregulate FIG4 to reduce the cell death of MNs and increase the neurite outgrowth under oxidative stress; moreover, EGCG can upregulate FIG4 to promote the functional recovery and the survival of MNs in the ventral horn in mice after BPRA. These combined results may lay the foundation for EGCG to be a novel strategy for the treatment of BPRA.

Published
2019
Full Text
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2. Epigallocatechin gallate enhances the motor neuron survival and functional recovery after brachial plexus root avulsion by regulating FIG4

Author

Weijun Tang, Yinjuan Tang, Yuxia Qiu, Yumei Tang, Lanbing Luo, Shengjie Wan, Jianjun Wang, Guihua Yue, and Shiyin Jiang

Subjects
0301 basic medicine, Programmed cell death, Neurite, Cell Survival, lcsh:Medicine, Epigallocatechin gallate, (-)-epigallocatechin-3-gallate (egcg), medicine.disease_cause, complex mixtures, Neuroprotection, Catechin, Pathology and Forensic Medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, In vivo, medicine, Animals, motor neurons, Brachial Plexus, neurodegenerative diseases, heterocyclic compounds, brachial plexus root avulsion, Cell Death, Flavoproteins, Chemistry, lcsh:R, food and beverages, Recovery of Function, Motor neuron, Cell biology, Mice, Inbred C57BL, Oxidative Stress, Neuroprotective Agents, 030104 developmental biology, medicine.anatomical_structure, Spinal Cord, fig4, sense organs, Neurology (clinical), Phosphoinositide Phosphatases, 030217 neurology & neurosurgery, Oxidative stress
Abstract

The survival of motor neurons (MNs) is the key to recovery of the motor function after brachial plexus root avulsion (BPRA). (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective roles in neurons under different pathological conditions. However, the role of EGCG in regulating motor neurons under BPRA remains to be unclear. In the present study, we investigated the functional role of EGCG bothiiiin vitro/i/i/iandiiiin vivo/i/i/i. In aniiiin vitro/i/i/istudy, we observed that EGCG obviously increased the cell survival rate of MNs and FIG4 protein levels compared with the vehicle control, with a peak level observed at 50 µM; EGCG can also upregulate FIG4 to reduce the cell death of MNs and increase the neurite outgrowth under oxidative stress; moreover, EGCG can upregulate FIG4 to promote the functional recovery and the survival of MNs in the ventral horn in mice after BPRA. These combined results may lay the foundation for EGCG to be a novel strategy for the treatment of BPRA.

Published
2019

3. Epigallocatechin gallate enhances the motor neuron survival and functional recovery after brachial plexus root avulsion by regulating FIG4.

Author

Tang Y, Wang J, Wan S, Luo L, Qiu Y, Jiang S, Yue G, Tang Y, and Tang W

Subjects
Animals, Brachial Plexus drug effects, Brachial Plexus pathology, Catechin pharmacology, Cell Death drug effects, Mice, Inbred C57BL, Motor Neurons pathology, Neuroprotective Agents pharmacology, Recovery of Function drug effects, Spinal Cord drug effects, Spinal Cord pathology, Catechin analogs & derivatives, Cell Survival drug effects, Flavoproteins drug effects, Motor Neurons drug effects, Oxidative Stress drug effects, Phosphoinositide Phosphatases drug effects
Abstract

The survival of motor neurons (MNs) is the key to recovery of the motor function after brachial plexus root avulsion (BPRA). (-)-epigallocatechin-3-gallate (EGCG) exerts neuroprotective roles in neurons under different pathological conditions. However, the role of EGCG in regulating motor neurons under BPRA remains to be unclear. In the present study, we investigated the functional role of EGCG both in vitro and in vivo . In an in vitro study, we observed that EGCG obviously increased the cell survival rate of MNs and FIG4 protein levels compared with the vehicle control, with a peak level observed at 50 µM; EGCG can also upregulate FIG4 to reduce the cell death of MNs and increase the neurite outgrowth under oxidative stress; moreover, EGCG can upregulate FIG4 to promote the functional recovery and the survival of MNs in the ventral horn in mice after BPRA. These combined results may lay the foundation for EGCG to be a novel strategy for the treatment of BPRA.

Published
2019
Full Text
View/download PDF

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