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Your search keyword '"S. Kwiecień"' showing total 2 results
Start Over Author "S. Kwiecień" Journal folia medica cracoviensia
2 results on '"S. Kwiecień"'

1. [Protective role of leptin in acute gastric ulcers].

Author

Ptak-Belowska A, Brzozowski T, Pajdo R, Pawlik M, Kwiecień S, Drozdowicz D, and Pawlik WW

Subjects
Acute Disease, Animals, Random Allocation, Rats, Rats, Wistar, Regional Blood Flow drug effects, Stomach Ulcer prevention & control, Anti-Ulcer Agents administration & dosage, Gastric Mucosa metabolism, Leptin administration & dosage, Leptin metabolism, Stomach Ulcer drug therapy, Stomach Ulcer metabolism
Abstract

There are few data concerning protective effects of leptin on gastric epithelium treated with necrotic factors: ethanol, bile salts and hiperosmotic solutions. Further investigations are needed to establish the role of hormone leptin in gastroprotection and in the process of chronic gastric ulcers healing in animals. Exogenous leptin administration plays protective effects against 75% ethanol damage in gastric epithelium. Nitric oxide is involved in gastroprotective effects of leptin and CCK.

Published
2008

2. [Candidiasis in the experimental model of ulcerative colitis].

Author

Zwolińska-Wcisło M, Sliwowski Z, Drozdowicz D, Kwiecień S, Mazurkiewicz-Janik M, Trojanowska D, Rudnicka-Sosin L, Mach T, Budak A, Brzozowski T, Konturek SJ, and Pawlik WW

Subjects
Animals, Antifungal Agents therapeutic use, Candidiasis blood, Candidiasis drug therapy, Colitis, Ulcerative blood, Colitis, Ulcerative drug therapy, Colon blood supply, Colon microbiology, Disease Models, Animal, Fluconazole therapeutic use, Interleukin-1beta blood, Male, Probiotics therapeutic use, Rats, Rats, Wistar, Tumor Necrosis Factor-alpha blood, Candida isolation & purification, Candidiasis diagnosis, Candidiasis microbiology, Colitis, Ulcerative microbiology
Abstract

In the present study on animal model of ulcerative colitis the influence of fungal colonization on the severity of inflammatory lesions in the colon and the course of their healing was evaluated. The results of our studies revealed, that significant fungal colonization (over 10(4) CFU/ml) delayed ulcer healing in the colon. It corresponded with the decrease of colonic blood flow (CBF) in the region of lesions and increase of interleukin (IL)-1beta, tumor necrosis factor(TNF)-alpha level in the serum. Introduction of antifungal therapy (fluconazole) or probiotic in rats inoculated with Candida accelerated the process of ulcer healing in the colon, expressed through the reduction of macro- and microscopic lesions in the colon and decrease of MPO, IL-beta TNF-alpha serum level.

Published
2007

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