1. Thermodynamic analysis and preferential solvation of sulfamethazine in acetonitrile + water cosolvent mixtures
- Author
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Claudia Patricia Ortiz, Nestor Enrique Cerquera, Joaquín H. Blanco-Márquez, Fleming Martínez, Daniel Ricardo Delgado, and Diego Ivan Caviedes Rubio
- Subjects
010405 organic chemistry ,Chemistry ,General Chemical Engineering ,Solvation ,General Physics and Astronomy ,Thermodynamics ,Inverse ,02 engineering and technology ,01 natural sciences ,Endothermic process ,0104 chemical sciences ,chemistry.chemical_compound ,020401 chemical engineering ,Molecule ,0204 chemical engineering ,Physical and Theoretical Chemistry ,Solubility ,Acetonitrile ,Solution process ,Mixing (physics) - Abstract
This paper presents the solubility of sulfamethazine (SMT) in the acetonitrile (MeCN) + water (W) cosolvent system at nine temperatures. From the solubility experimental data, the thermodynamic functions of solution, mixing, and transfers are calculated and analyzed using the Perlovich graphical method. On the other hand, an enthalpy−entropy compensation analysis is performed and the preferential solvation parameters are calculated using the Kirkwood-Buff (IKBI) inverse integral method. The result of the performed calculations indicates that the SMT solution process is endothermic with entropic favor, where the addition of MeCN has a positive cosolvent effect between pure water and the mixture with w1 = 0.90. As for the preferential solvation, the SMT molecule is preferentially surrounded by water in water- and MeCN-rich mixtures, and in intermediate mixtures, the SMT molecule tends to be surrounded by MeCN.
- Published
- 2020
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